Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2010.1066.1076MansourianAzad Reza1220101322Thyrotoxicosis exhibit collective clinical manifestation, caused by excessive serum thyroid hormones particularity thyroxin. The clinical signs and symptoms included general alteration of metabolic process leading to weight loss fatigue and weakness and some specific disorders such as cardiovascular, neuromuscular reproductive gastrointestinal dermatological and bone disorders. The diagnosis of thyrotoxicosis relay on the thyroid function test carried out by the laboratory serum measurement of thyroxin, triidothyuronin and thyroid stimulating hormones accompanied by other para-medical examinations suggested by clinicians and endociologicst. In thyrotoxicosis serum level of thyroid hormones and thyroxin in particular elevated accompanied by pituitary thyroid stimulating hormone suppression reaching to undetectable level in sever thyrotoxicosis. Among the most common cause of thyrotoxicosis are, thyroid autoimmunitiy diseases thyroid toxic, adenoma toxic nodular and multinodular hyperthyroidism. The main aim behind this review is to explore the clinical manifestation, the causative factors, diagnosis, metabolic disorder occur due to thyrotoxicosis.]]>Al-Khafaji, F., M. Wiltshire, D. Fuhrer, G. Mazziotti, M.D. Lewis, P.J. Smith and M. Ludgate,200534209220Anderson, N.R., J.J. Lokich, W.V. McDermott Jr., C. Tery and K.R. Falchuk,197944304306Bransom, C.J., G.H. Talbot, L. Henry and J. Elemenoglou,197966590595Becker, C. and C. Cornette,197132852854Becjer, F.O., P.G. Economou and T.B. Schwartz,196358877882Berglud, J., U.B. Ericsoon and B. Hallengren,19962395762Bogazzi, F., L. Bartalena, M. Gasperi, L.E. Braverman and E. 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