Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2010.148.151Myrmecodya pendens) to HeLa and MCM-B2 Cells]]>SoeksmantoA. SubrotoM. A.WijayaH. SimanjuntakP. 32010133The aim of this study is to investigate anticancer activity of methanol extract (ethylacetate, n-buthanol and water partitions) and water extract from Sarang semut (local name), Myrmecodya pendens which is one of Rubiaceae family. Within Papua area (Indonesia), this medicinal plant has been used traditionally as alternative treatment for ulcer, tumor and cancer. In this study, the extracts of this plant were tested for their activities in some cancer cells (HeLa and MCM-B2 cell). The result showed that water extract of this plant has better anti cancer activity compared to other extracts. The IC50 value of water extract A is 27.61 ppm (HeLa) and 54.57 ppm (MCM-B2), while water extract B is 29.36 ppm (HeLa) and 74.20 ppm (MCM-B2). Our study concluded that polar extract (water) exhibited higher anticancer activity than non-polar extracts (ethylacetate and n-buthanol).]]>Calabresi, P. and B. Chabner,19918th Edn.,pp: 1202-1290pp: 1202-1290Fotsis, T., M.S. Pepper, E. Aktas, S. Breit and S. Rasku et al.,1997in vitro angiogenesis.]]>5729162921Green, D., K.D. Tew, T. Hisamatsu and P.S. Schein,19823116711679Harun, N. and W. Syari,200276370Hertog, M.G.L., P.C.H. Hollman, M.B. Katan and D. Kromhout,1993202129Herzig, R.H., J.D. Hines and G.P. Herzin,19875927932Hoppe, R.T., C.N. Coleman, R.S. Cox, S.A. Rosenberg and H.S Kaplan,198259455465Lopez-Lazaro, M.,20022691714Park, E.J. and J.M. Pezzuto,200221231255Philip, P.A.,200532S2438Prachayasittikul, S., P. Buraparuangsang, A. Worachartcheewan, C. Isarankura-Na-Ayudhya, S. Ruchirawat and V. Prachayasittikul,200813904921Pramono, E.,1999Subroto, M.A. and H. Saputro,2006pp: 11-22pp: 11-22Yi, W., J. Fischer, G. Krewer and C.C. Akoh,20055373207329