Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2011.1109.1116SameriMaryam JafarSarkakiAlireza FarboodYaghoub MansouriSeyed Mohammad Taghi1220111424The aim of this study was evaluation the effect of Gallic acid on movement disorders and pallidal electrical power in animal model of Parkinsons Disease (PD). PD is clinically characterized by development of motor disturbances, such as bradykinesia, resting tremors, rigidity and a later loss of postural reflexes. Oxidative stress is a hallmark factor where the oxidation of dopamine generates Reactive Oxygen Species (ROS) and an unbalanced production ROS induces neuronal damage, therefor leading the neuronal death. Gallic Acid (GA) and its derivatives are present in the plant kingdom and acts as a potent antioxidant. Wistar male rats devided into seven groups randomly with 8 in each. Animals in all groups except control received 8 μg/2 μL 6-hydroxydopamine dissolved in normal saline contains 0.01% ascorbate or vehicle in right Medial Forbrain Bundle (MFB) and a bipolar wire electrode was implanted in the left globus pallidus nucleus of all animals under stereotaxic surgery. Two weeks later PD was approved by contralateral rotation signs induced by apomorphine and then movements and electrical power of pallidal were evaluated. Motor functions and pallidal electrical power were impaired and GA could improve motor dysfunctions and gamma wave power in parkinsonian rats significantly with higher dose of GA (200 mg kg-1). Present result showed that GA may act as a potent antioxidant and free radical scavenger to reverse motor disorders and pallidal gamma wave power after 6-OHDA neurotoxicity in brain.]]>Da Cunha, C., M.E.M. Angelucci, N.S. Canteras, S. Wonnacott, R.N. Takahashi,200222227237Dekundy, A., M. Pietraszek, D. Schaefer, M.A. Cenci and W. Danysz,200669318326Doulah, A.H., A.H. Rohani, H.M. Khaksari, F. Motamedi and Y. Farbood et al.,20094664751Esposito, E., D. Rotilio, V. Di Matteo, C. Di Giulio, M. Cacchio and S. Algeri,200223719735Hsiao, G., C.M. Teng, J.R. Sheu, Y.W. Cheng and K.K. Lam et al.,200115257788Jadon, A., M. Bhadauria and S. Shukla,2007Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats.]]>109214218Jimenez-Del-Rio, M., C. Guzman-Martinez and C. Velez-Pardo,2010Drosophila melanogaster exposed to iron and paraquat.]]>35227238Jimenez, A., C. Marin, M. Bonastre and E. Tolosa,1999839190193Li, L., T.B. Ng, W. Gao, W. Li and M. Fu et al.,200577230240Lu, Z., G. Nie, P.S. Belton, H. Tang and B. Zhao,200648263274Metz, G.A., A. Tse, M. Ballermann, L.K. Smith and K. Fouad,200522735744Niki, E.,200947469484Paxinos, G. and C. Watson,20066th Edn.,Sarkaki, A., M. Badavi, N. Hoseiny, M.K. Gharibnaseri and F. Rahim,2008154940945Shahrzad, S., K. Aoyagi, A. Winter, A. Koyama and I. Bitsch,200113112071210Soto-Otero R., E. Mendez-Alvarez, A. Hermida-Ameijeiras, A.M. Munoz-Patino and J.L. Labandeira-Garcia,20007416051612Soto-Otero, R., E. Mendez-Alvarez, A. Hermida-Ameijeiras, A.M. Munoz-Patino, A.M. Lopez-Real and J.L. Labandeira-Garcia,200264125135Sultana, R., M. Perluigi and D.A. Butterfield,2006820212037Tadaiesky, M.T., P.A. Dombrowski, C.P. Figueiredo, E. Cargnin-Ferreira, C.C. Da and R.N. Takahashi,2008156830840Tanaka, K., N. Ogawa and M. Asanumab,20064108589Tiffani-Castiglioni, E., R.P. Saneto, P.H. Proctor, J.R. Perez-Polo,198231181188Tung, Y.T., J.H. Wu, C.C. Huang, H.C. Peng, Y.L. Chen, S.C. Yang and S.T. Chang,20094713851392Yeh, C.T., L.C. Ching and G.C. Yen,200920163171Zigmond, M.J. and R.E. Burke,20022002pp: 1881-1884pp: 1881-1884