Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2011.375.384AbdeenSherif H.62011146Anti-idiotypes (anti-Ids) have a potential role in the immune modulation of various diseases. To study the correlation of anti-Ids with schistosomiasis mansoni morbidity, ELISA using polyclonal idiotypes (Ids) was used to determine the presence of anti-Ids in sera of 69 patients susceptible and resistant to re-infection. Ids were purified against Soluble Worm Antigen (SWAP) from sera of New Zealand white rabbits immunized with SWAP. The results showed that anti-Ids were detected in 15 (40.5%) of susceptible and 21 (65.6%) of resistant patients. Correlation of intensity of infection with age revealed an inverse relationship in patients positive for anti-Ids (regression coefficient β = - 0.47, p<0.05) and contrarily, a direct relationship in patients negative for anti-Ids (β = 0.67, p<0.001). In addition, there was a direct association between the presence of anti-Ids and the lack of schistosome-related symptoms (χ2 = 3.6, p<0.05) and hepatomegaly (χ2 = 9.4, p<0.01). Moreover, comparison of patients positive and negative for anti-Ids revealed that those negative for anti-Ids were more vulnerable to develop symptoms (3.7 times) and hepatomegaly (8.1 times). In conclusion, the study further confirms the role of Id/anti-Id regulatory network as an important participant in the assortment of an improved clinical outcome of schistosomiasis. This may help to formulate a better understanding of the mechanisms of protective immunity in humans and provide perspective for the development of a future vaccine.]]>Abdeen, S.H.,200013367383Abdel-Aziz, M.M., A.T. Abbas, K.A. Elbakry, E.A. Toson and M. El-Sherbiny,2006Schistosoma mansoni and treated with myrrh.]]>6858861Ali, S.A.,20115120Al-Khafif, M.A., H.I. Shaheen, R.M. Farag and M.K. 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