Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2011.775.779Urtica dioica) Extracts on Insulin Sensitivity and Some Inflammatory Indicators in Patients with Type 2 Diabetes: A Randomized Double-blind Control Trial]]>NamaziN. EsfanjaniA.T. HeshmatiJ. BahramiA. 1220111415Type 2 diabetes is a metabolic disorder that is strongly associated with cardiovascular risk. Inflammation is a potential risk factor for cardiovascular disease. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on insulin sensitivity and some inflammatory indicators in type 2 diabetic patients were studied. A randomized double-blind clinical trial on 50 men and women with type 2 diabetes was done for 8 weeks. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into two groups, an intervention and control group. They received, 100 mg kg-1 nettle extract or placebo in three portions a day for 8 weeks. Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) , High Sensitive C-Reactive protein (hs-CRP) and Fasting Insulin concentration were measured. Insulin Sensitivity was calculated, at the beginning and the end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, IL-6 and hs-CRP showed a significant decrease in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has decreasing effects on IL-6 and hs-CRP in patients with type 2 diabetes after eight weeks intervention.]]>Biondi-Zoccai, G.G., A. Abbate, G. Liuzzo and L.M. Biasucci,20034110711077Bnouham, M., A. Ziyyat, H. Mekhfi, A. Tahri and A. Legssyer,200614125Das, M., B.P. Sarma, A.K.A. Khan, M. Mosihuzzaman and N. Nahar et al.,2009Urtica dioica L. on type2 diabetic model rats.]]>1716Egede, L.E., X. Ye, D. Zheng and M.D. Silverstein,200225324329Farzami, B., D. Ahmadvand, S. Vardasbi, F.J. Majin and S. Khaghani,2003in vivo effects in normal and streptozotocin diabetic rats.]]>894753Hagstromer, M., P. Oja and M. Sjostrom,20069755762Chrubasik, J.E., B.D. Roufogalis, H. Wagner and S.A. Chrubasik,200714568579Katz, A., S.S. Nambi, K. Mather, A.D. Baron, D.A. Follmann, G. Sullivan and M.J. Quon,20008524022410Khan, A. and M. Safdar,20032112Meier-Ewert, H.K., P.M. Ridker, N. Rifai, M.M. Regan, N.J. Price, D.F. Dinges and J.M. Mullington,200443111117Obertreis, B., K. Giller, T. Teucher, B. Behnke and H. Schmitz,1996465256Onal, S., S. Timur, B. Okutucu and F. Zihnioglu,2005352936Petlevski, R., M. Hadzija, M. Slijepcevic and D. Juretic,200175181184Qujeq, D., S. Davary, Z. Moazzi and S. Mahjoub,2011Urtica dioica leaf extract on activities of nucleoside diphosphate kinase and acetyl coenzyme, a carboxylase, in normal and hyperglycemic rats.]]>5792796Riehemann, K., B. Behnke and K. Schulze-Osthoff,1999Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-κB.]]>4428994Rotter, V., I. Nagaev and U. Smith,20032784577745784Shaw, J.E., R.A. Sicree and P.Z. Zimmet,201087414Taylor, R.,20085117811789Wellen, K.E. and G.S. Hotamisligil,200511511111119Thorn, A.,2007Urtica dioica: Urtica urens (Nettle).]]>12280284Mehri, A., S. Hasani-Ranjbar, B. Larijani and M. Abdollahi,2011Urtica dioica in the treatment of diabetes.]]>7161170