Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.1085.1089Nepeta menthoides Aqueous Extract on Retention and Retrieval of Memory in Mice]]>SarahroodiS. Jafari-NajafiR. NasriS. RohampourK. Maleki-JamshidA. EsmaeiliS. 1220121522There are several evidences that plants and vegetables with antioxidant activity can reduce oxidative damages in brain and improve cognitive functions. The aim of this study was evaluation of Nepeta menthoidesaqueous extract on memory retention and retrieval of mice by using passive avoidance apparatus. For this purpose, mice were classified, coded, weighted and grouped (n = 8) as follow as: control group (Only electric shock), blank group (electric shock plus normal saline) and test groups (electric shock plus Nepeta menthoides extract by doses: 100, 200, 400 and 800 mg kg-1, i.p.). Delay time of leaving the platform was measured for retention and retrieval test of memory in all mentioned groups. In retention test, plant extract was administered immediately after receiving electric shock while it was administered 24 h after receiving electric shock in retrieval. The results revealed that Nepeta menthoides aqueous extract significantly (p<0.05) increased memory retention and retrieval. The best response for memory retention and retrieval was achieved with 800 mg kg-1 of Nepeta extract. In conclusion, enhancement of memory retention and retrieval by Nepeta menthoides could be cause of antioxidant activity of its components such as rosmarinic acid, caffeic acid and phenolic acids.]]>Abe, K. and H. Saito,200014149152Alikatte, K.L., B.R. Akondi, V.G. Yerragunta, P.R. Veerareddy and S. Palle,2012Syzygium cumini against scopolamine induced spatial memory impairments in rats.]]>34844851Arzi, A., S. Sarahroodi, M.M. Honarmand, S. Jamshidi and M. Latifi,20101310421046Baser, K.H.C., N. Kirimer, M. Kurkcuoglu and B. Demirci,2000Nepeta species growing in Turkey.]]>36356359Bishnoi, M., K. Chopra and S.K. Kulkarni,200888511522Chepulis, L.M., N.J. Starkey, J.R. Waas and P.C. Molan,200997359368Cigremis, Y., Z. Ulukanli, A. Ilcim and M. Akgoz,2010In vitro antioxidant and antimicrobial assays of acetone extracts from Nepeta meyeri Bentham.]]>14661668Dokania, M., K. Kishore and P.K. Sharma,2011Ocimum sanctum extract on sodium nitrite-induced experimental amnesia in mice.]]>35123130Duke, J.,2002Evans, W.C.,1996Hussain, J., N. Jamila, S.A. Gilani and G. Abbas,2010Nepeta juncea.]]>8935940Jamila, N., R. Ullah, M. Ali, A. Alwahsh, S. Haider, K.C. Wong and Z. Ullah,2011Nepeta juncea.]]>101788417886Joshi, H. and M. Parle,2006Ocimum tenuiflorum linn.]]>68364365Kraujalis, P., P.R. Venskutonis and O. Ragazinskiene,2011Nepeta plant species.]]>2011pp: 7983Kumar, S.R., S.M. Rao, S. Nayak and N.N. Sareesh,2007Ocimum sanctum (Linn) extract on restraint stress induced behavioral deficits in male wistar rats.]]>3394404Kiyani, N., A. Kiyani, M. Khademizadeh, M.R. Pazuki, F.A. Mamghani and A.M. Dehshiri,201278PI449PI449Lee, Y.J., D.Y. Choi, S.B. Han, Y.H. Kim and K.H. Kim et al.,2012Magnolia officinalis on memory impairment and amyloidogenesis in a transgenic mouse model of Alzheimer's disease via regulating β-secretase activity.]]>2618841892Rabbani, M., S.E. Sajjadi and A. Mohammadi,2008Nepeta persica Boiss. in mice.]]>5181186Rai, G.S., C. Shovlin and K.A. Wesnes,199112350355Rigney, U., S. Kimber and I. Hindmarch,1999Ginkgo biloba extract on memory and psychomotor performance in volunteers.]]>13408415Rubio, J., W. Qiong, X. Liu, Z. Jiang, H. Dang, S.L. Chen and G.F. Gonzales,2011Lepidium meyenii) on memory impairment induced by ovariectomy in mice.]]>2011Sarahroodi, S.,2006Sarahroodi, S.,201285859Sarahroodi, S. and A. Arzi,20099829832Sarahroodi, S., A. Arzi, A.F. Sawalha and A. Ashtarinezhad,201064852Sarahroodi, S., A. Maleki-Jamshid, A.F. Sawalha, P. Mikaili and L. Safaeian,201219125129Sarahroodi, S., S. Esmaeili, P. Mikaeili, Z. Hemmati and Y. Saberi,2012Ocimum basilicum hydroalcoholic extract on memory retention and retrieval of memory in mice.]]>31172176Sujatha, S., R. Bhat, C. Kannan and D. Balasimha,2011Areca catechu L.) plantation in India.]]>337883Sujith, K., C.R. Darwin, Sathish and V. Suba,2012Anacyclus pyrethrum in albino Wistar rats.]]>2307311Ullah, R.,2011Nepeta juncea.]]>562546256Wu, K.J., M.T. Hsieh, C.R. Wu, W.G. Wood and Y.F. Chen,20122012Zargari, A.,1990Zarrindast, M.R., M. Dorrani, R. Lachinani and A. Rezayof,2010672532