Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.250.254TabarsiBahareh PourghasemMohsen MoghaddamniaAliakbar ShokraviMarziyeh EhsaniMaryam AhmadyarMaryam AsgarySaeed 52012155In this in vivo study, the skin reactivity of rabbits to Mineral Trioxide Aggregate (MTA) and Calcium Enriched Mixture (CEM) was compared. Sixteen albino rabbits were used. The dorsal skin in three areas (2x2 cm) of the rabbits was shaved 24 h prior to the test. The areas were randomly covered with freshly mixed biomaterials [MTA (n = 16), CEM (n = 16) and normal saline (control; n = 16)], sterile gauze and bandages were placed for 4 h and the biomaterials were washed. The surface areas of the reactive skin sections were examined by naked eye and measured in 1, 24, 48 and 72 h using the Cavalier technique. The animals were then sacrificed and histological sections were prepared for blind examination. Results of macroscopic examination revealed a significant difference (p = 0.003) between the average erythematous surface areas induced by MTA (1.61±0.32) and CEM (0.5±0.16). Results of histological examination showed that the highest inflammation was observed in MTA, followed by CEM and control groups. Comparison of the difference in inflammatory cell count between each group revealed statistically significant differences in all cases (p<0.001). The results demonstrated that the biocompatibility of CEM cement is higher than MTA; CEM can be considered as a suitable endodontic biomaterial.]]>Abbasalipourkabir, R., A. Salehzadeh and R. Abdullah,201110528533Ghazvini, S.A., M.A. Tabrizi, F. Kobarfard, A.A. Baghban and S. Asgary,200947478Asgary, S. and F.A. Kamrani,200850469474Asgary, S., S. Shahabi, T. Jafarzadeh, S. Amini and S. Kheirieh,200834990993Asgary, S., M.J. Eghbal and M. Parirokh,200887706709Asgary, S., M.J. Eghbal and S. Ehsani,201036837841Asgary, S., M.J. Eghbal, M. Parirokh and J. Ghoddusi,200935147152Asgary, S., M.J. Eghbal, M. Parirokh, F. Ghanavati and H. Rahimi,2008106609614Asgary, S., M.J. Eghbal, M. Parirokh, J. Ghoddusi, S. Kheirieh and F. Brink,200935243250Eghbal, M.J., S. Asgary, R.A. Baglue, M. Parirokh and J. Ghoddusi,20093548Jafari, N.J., M. Ghasemi, M. Izadi and M. Rezaee,20071010681072Mahvi, A.H., M.A. Zazoli, M. Younecian, B. Nicpour and A. Babapour,20066658661Missebukpo, A., K. Metowogo, A. Agbonon, K. Eklu-Gadegbeku, K. Aklikokou and M. Gbeassor,2011Ixora coccinea Linn (Rubiaceae).]]>6559570Moretton, T.R., C.E. Brown Jr., J.J. Legan and A.H. Kafrawy,200052528533Motlagh, M.G., G.R.J. Khaniki and H. Adiban,20077116120Mozayeni, M.A., A.S. Milani, L.A. Marvasti and S. Asgary,20102010Ouedraogo, M., E.C. Nacoulma, R. Semde, I.T. Some and I.P. Guissou et al.,2008In vitro biocompatibility and genotoxicity assessment of a gentamicin-loaded monoolein gel intended to treat of chronic osteomyelitis.]]>3394401Ouedraogo, M., M. Sanou, N. Ramde, O. Goumbri and I.T. Some et al.,2008In vivo biocompatibility and toxicity assessment of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis.]]>3386393Parirokh, M. and M. Torabinejad,2010361627Parirokh, M. and M. Torabinejad,201036400413Rezaei-Tavirani, M., H. Zali, L. Nabai, P. Toossi, F.M. Zad and Y. Pourkhoshbakht,200811925929Saalu, L.C., P.I. Jewo, O.E. Yama and J.A. Oguntola,20116409417Samiee, M., M.J. Eghbal, M. Parirokh, F.M. Abbas and S. Asgary,201014653658Sumer, M., M. Muglali, E. Bodrumlu and T. Guvenc,20063210941096Tabarsi, B., M. Parirokh, M.J. Eghbal, A.A. Haghdoost, H. Torabzadeh and S. Asgary,201043565571Torabinejad, M., C.U. Hong, F. McDonald and T.R.P. Ford,199521349353Torabinejad, M. and N. Chivian,199925197205Torabinejad, M. and M. Parirokh,201036190202Torabinejad, M., R.K. Higa, D.J. McKendry and T.R.P. Ford,199420159163Torabinejad, M., T.R.P. Ford, D.J. McKendry, H.R. Abedi, D.A. Miller and S.P. Kariyawasam,199723225228Yaltirik, M., H. Ozbas, B. Bilgic, H. Issever,2004309599Mobarak, Y.M.,2011in vivo and in vitro developmental toxicity and teratogenicity of the anti-AIDS drugs (human and experimental animal studies).]]>6208236Zmener, O.,200430348351Nosrat, A. and S. Asgary,201036912914