Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.290.295BiswasS.K. PaulS. ChowdhuryA. DasJ. 62012156Gastroretentive floating pellets of metronidazole were formulated to prolong the gastric residence time in order to obtain controlled release characteristics of the drug. Nine formulations of metronidazole floating pellets such as AX, BX, CX, AY, BY, CY, AZ, BZ and CZ were prepared by extrusion method using different quantities of hydroxyl propyl methyl cellulose (HPMC) polymers such as methocel K4M premium and methocel K100LV premium in the ratio of 2:1, 1:2 and 1.5:1.5 while the amount of Na-alginate used in the formulations was 3.50, 5.25 and 7.0 g, respectively. The in vitro dissolution studies were carried out in 900 mL of phosphate buffer (pH 1.2) at 37±0.5°C and 50 rpm for 6 h using USP XXIV paddle method and the content of drug release was done by UV spectrophotometer at 277 nm. It was found that the percent release of metronidazole from different formulations was different with passing of time. The drug release profile of the formulation (AX) having Na-alginate 3.50 g methocel K4M premium and methocel K100LV premium in the ratio of 2:1 showed best fit to Higuchi release kinetics with R2 value of 0.994. Finally, it might be concluded that the polymers had significant effect on drug release kinetics of metronidazole from floating pellets. The selection and use of suitable polymers in appropriate ratio might be very important in designing floating pellets and using the capabilities of these polymers, suitable floating pellets of metronidazole with desirable release rate could be formulated. Thus, in vivo research studies by the future researchers will confirm the appropriateness of these formulated metronidazole floating pellets.]]>Adibkia, K., S. Hamedeyazdan and Y. Javadzadeh,20118891903Asnaashari S., N.S. Khoei, M.H. Zarrintan, K. Adibkia and Y. Javadzadeh,201116400407Babu, G.D., S.R. Chandra, A.S. Devi, B.V.V. Reddy and N.S. Latha,2011216571662Balamuralidhara, V., T.M. Pramodkumar, N. Srujana, M.P. Venkatesh, N.V. Gupta, K.L. Krishna and H.V. Gangadharappa,201112448Hamdani, J., A.J. Moes and K. Amighi,2006In vitro evaluation of a novel floating multiple unit dosage form obtained by melt pelletization.]]>32296103Hossain, M.D.B., M. Rashid and A.K.M.M. Hossain,20047772776Khan, G.M.,20011350354Mownika, G. and P. Srinivas,2012in situ implants.]]>287100Trivedi, N.D., U.N. Trivedi, M.M. Patel, J.K. Patel and A. Bhandari,20111823Natarajan, R., N. Kaveri and N.N.R. Rajndran,20112765771Obitte, N.C., H. Ezeiruaku and V.I. Onyishi,2008819501955Pahwa, R., N. Saini, V. Kumar and K. Kohli,20129525539Reddy, A.B., B.S. Rani, D.E. Tony, D.S. Raja, L. Sindhura and N.S. Kumar,20113290300Shah, S., R. Qaqish, V. Patel and M. Amiji,1999Helicobacter pylori infection.]]>51667672Shaheen, S.M., M.N. Hossen, K.M. Islam, M. Ahmed, M.S. Amran and M. Rashid, 20062504508Supriya, P., B. Rajni and A.C. Rana,201234347Vani, M., A. Meena, F.G. Savio and M.P. Nancy,2010114