Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.316.324AsemiZatollah TabassiZohreh HeidarzadehZahra KhorammianHassan SabihiSima-Sadat SamimiMansooreh 72012157Increased metabolic profiles during pregnancy are associated with an increased risk of maternal and neonatal morbidity and remain a significant medical challenge. To our knowledge, no reports are available indicating the effects of calcium-vitamin D supplementation on metabolic profiles among pregnant women at risk for pre-eclampsia. This study was designed to determine the effects of consumption calcium-vitamin D supplements on metabolic profiles among Iranian pregnant women at risk for pre-eclampsia. This randomized single-blind controlled clinical trial was performed among 49 pregnant women at risk for pre-eclampsia, primigravida, aged 18-35 year old who were carrying singleton pregnancy at their third trimester. Subjects were randomly assigned to consume the placebo (n = 25) or calcium-vitamin D supplements (n = 24) for 9 weeks. Calcium-vitamin D supplements were containing 500 mg carbonate calcium plus 200 IU vitamin D3. Fasting blood samples were taken at baseline and after 9 week intervention to measures of Fasting Plasma Glucose (FPG) and serum lipid profiles. Consumption of calcium-vitamin D supplements resulted in decreased FPG and serum triglycerides levels as compared to the placebo (-9.1 vs. 0.5 mg dL-1; p = 0.03, -11.7 vs. 49.9 mg dL-1; p = 0.001, respectively). No significant differences were found comparing calcium-vitamin D supplements and the placebo in terms of their effect on serum total-, HDL-, LDL-cholesterol levels. Within-group differences in the placebo group revealed a significant increase in serum triglycerides levels (+49.9 mg dL-1, p<0.0001). In conclusion, consumption of calcium-vitamin D supplements for 9 weeks during pregnancy among pregnant women at risk for pre-eclampsia resulted in decreased FPG and serum triglycerides levels as compared to the placebo group, but could not affect serum total-, HDL-, LDL-cholesterol levels.]]>Jahromi, A.S., P. Zareian and A. Madani,20116366372Jahromi, A.S., P. Zareian and A. Madani,2011616Alvarez, J.A. and A. Ashraf,20102010Asemi, Z., S. Jazayeri, M. Najafi, M. Samimi and V. Mofid et al.,201114476482Bayhan, G., Y. Kocyigit, A. Atamer, Y. Atamer and Z. Akkus,20052116Belo, L., M. Caslake, D. Gaffney, A. Santos-Silva, L. Pereira-Leite, A. Quintanilha and I. Rebelo,2002162425432Berends, A.L., C.J.M. de Groot, E.J. Sijbrands, M.P.S. Sie and S.H. Benneheij et al.,20085110341041Brizzi, P., G. Tonolo, F. Esposito, L. Puddu, S. Dessole, M. Maioli and S. Milia,1999181430434Carty, D.M., C. Delles and A.F. Dominiczak,20102813491355Cho, H.J., H.C. Kang, S.A. Choi, Y.C. Ju, H.S. Lee and H.J. Park,20052+ on the activation of microsomal triglyceride transfer protein in rat hepatocytes.]]>2814181423De Boer, I.H., L.F. Tinker, S. Connelly, J.D. Curb and B.V. Howard et al.,200831701707Devaraj, S., G. Jialal, T. Cook, D. Siegel and I. Jialal,2011437274Duley, L.,200933130137Eftekhari, M.H., M. Akbarzadeh, M.H. Dabbaghmanesh and J. Hasanzadeh,201120521526Gagnon, C., Z.X. Lu, D.J. Magliano, D.W. Dunstan and J.E. Shaw et al.,20122012Ghio, A., A. Bertolotto, V. Resi, L. Volpe and G. Di Cianni,201155133153Girouard, J., Y. Giguere, J.M. Moutquin and J.C. Forest,20074910561062Gupta, P., M. Narang, B.D. Banerjee and S. Basu,20042004Horgan, R.P., D.I. Broadhurst, S.K. Walsh, W.B. Dunn and M. Brown et al.,20111036603673Jorde, R., Y. Figenschau, M. Hutchinson, N. Emaus and G. Grimnes,20106414571464Jorde, R. and G. Grimnes,201150303312Jorde, R., M. Sneve, P. Torjesen and Y. Figenschau,2010267462472Karandish, M., S. Shockravi, M.T. Jalali and M.H. Haghighizadeh,200963268272Khattab, S., I.A. Mohsen, I. Aboul foutouh, H.S. Ashmawi and M.N. Mohsen et al.,201127789793Khoury, J., T. Henriksen, I. Seljeflot, L. Morkrid, K.F. Froslie and S. Tonstad,2007114279288Kirwan, J.P., S. Hauguel-De Mouzon, J. Lepercq, J.C. Challier and L. Huston-Presley et al.,20025122072213Kusters, D.M., S.J. Homsma, B.A. Hutten, M.T. Twickler, H.J. Avis, J.A. van der Post and E.S. Stroes,201068299303Lawlor, D.A., S.M. Morton, D. Nitsch and D.A. Leon,2005594955Li, Y., C. Wang, K. Zhu, R.N. Feng and C.H. Sun,20103410701077Major, G.C., F. Alarie, J. Dore, S. Phouttama and A. Tremblay,2007855459Mankuta, D., M. Elami-Suzin, A. Elhayani and S. Vinker,20102010Maymone, A.C., J.P. Baillargeon, J. Menard and J.L. Ardilouze,201110227238Mehendale, S., A. Kilari, K. Dangat, V. Taralekar, S. Mahadik and S. Joshi,2008100234238Naharci, I., E. Bozoglu, N. Kocak, S. Doganci, H. Doruk and M. Serdar,20112011Ndububa, D.A., O.S. Ojo, V.A. Adetiloye, O. Rotimi, M.A. Durosinmi and L.O. Uchegbu,19991114011404Pietrzak, A., J. Kadzielewski, K. Janowski, J. Rolinski and D. Krasowska et al.,200948379387Pikilidou, M.I., A.N. Lasaridis, P.A. Sarafidis, C.D. Befani and G.G. Koliakos et al.,200926211219Pittas, A.G., S.S. Harris, P.C. Stark and B. Dawson-Hughes,200730980986Reid, I.R.,200421717Reid, I.R. and M.J. Bolland,200811280286Rossner, S. and A. Ohlin,19953267s275sSaleh, J., K. Cianflone, T. Chaudhary, H. Al-Riyami, A.R. Al-Abri and R. Bayoumi,200715646652Sanchez, M., A. de la Sierra, A. Coca, E. Poch, V. Giner and A. Urbano-Marquez,199729531536Schleithoff, S.S., A. Zittermann, G. Tenderich, H.K. Berthold, P. Stehle and R. Koerfer,200683754759Sibai, B.M., J. Hauth, S. Caritis, M.D. Lindheimer and C. MacPherson et al.,2000182938942Solomon, C.G., J.S. Carroll, K. Okamura, S.W. Graves and E.W. Seely,199912276282Tai, K., A.G. Need, M. Horowitz and I.M. Chapman,200824950956Torres, D.D.O.C., A.C.O. Dos Santos, A.K.S.E. Silva, J.I.A. Leite, J.R.B. De Souza, E.I.C. Beltrao and C.A. Peixoto,201089164170Uzan, J., M. Carbonnel, O. Piconne, R. Asmar and J.M. Ayoubi,20117467474Valdes, G., P. Kaufmann, J. Corthorn, R. Erices, K.B. Brosnihan and J. Joyner-Grantham,20092009Vaskonen, T.,200314492506Von Hurst, P.R., W. Stonehouse and J. Coad,2010103549555Wang, H., N. Xia, Y. Yang and D.Q. Peng,20122012Wehmeier, K., A. Beers, M.J. Haas, N.C. Wong, A. Steinmeyer, U. Zugel and A.D. Mooradian,20053.]]>17371626Weisberg, S.P., D. McCann, M. Desai, M. Rosenbaum, R.L. Leibe and A.W. Ferrante Jr.,200311217961808Winkler, K., B. Wetzka, M.M. Hoffmann, I. Friedrich and M. Kinner et al.,20008545434550Zemel, M.B., H. Shi, B. Greer, D. DiRienzo and P.C. Zemel,20001411321138Zemel, M.B., W. Thompson, A. Milstead, K. Morris and P. Campbell,200412582590Zittermann, A., S.S. Schleithoff and R. Koerfer,200594483492Brown, L., B. Rosner, W.W. Willett and F.M. Sacks,1999693042Chung, M., E.M. Balk, M. Brendel, S. Ip and J. Lau et al., 20092009Hermansen, K., B. Hansen, R. Jacobsen, P. Clausen and M. Dalgaard et al.,200559843850Nakamura, Y., N. Okuda, T.C. Turin, A. Fujiyoshi, T. Okamura et al.,201020S544S548Pittas, A.G., M. Chung, T. Trikalinos, J. Mitri and M. Brendel et al., 2010152307314Ploumidou, K., A. Kyroudi-Voulgari, D. Perea, I. Anastasiou and D. Mitropoulos,2010761517.e11517.e5Ros, E. and J. Mataix,200696S29S35Sankar, D., G. Sambandam, M.R. Rao and K.V. Pugalendi,200535597104Sudhakar, B., P. Kalaiarasi, K.S. Al-Numair, G. Chandramohan, R.K. Rao and K.V. Pugalendi,201132379385Wang, L., J.E. Manson, Y. Song and H.D. Sesso,2010152315323