Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.454.458AmirabiAfsaneh NajiSiamak YektaZahra SadeghiYeganeh 92012159Several laboratory parameters have been used in these studies to diagnose chorioamnionitis leading to controversies to some extent. The aim of this study was to assess the diagnostic value of C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR) and White Blood Cell (WBC) count in chorioamnionitis among pregnant women with Premature Rupture Of Membranes (PROM). In a cross-sectional diagnostic test research, 71 patients presented with PROM before the 37th week of gestation were enrolled. A blood sample was taken from all the patients. Hematologic automatic blood cell counter was used to count the blood cells and their differentiation. ESR and CRP were also measured using the same blood sample at the laboratory. Sensitivity, specificity, correct classification rate and likelihood ratios were calculated. Receiver operating curves were plotted and area under curve was estimated along with its 95% confidence interval. A total of 71 patients were studied. None of the patients had a positive drug history or a history of hypertension before the 20th week of gestation or during her previous pregnancy. Contrary to ESR, WBC count and CRP results didnt provide minimum acceptable diagnostic accuracy measures for diagnosis of chorioamnionitis. The sensitivity and specificity of a positive ESR test at a cutoff value of 52 were 66.7 and 60%, respectively. The area under curve was calculated to be 0.62. The findings of the present study were not supportive of using CRP, WBC as a reliable diagnostic test to identify chorioamnionitis in women with PROM. The results of CRP and WBC were not acceptable but ESR diagnostic value was minimally acceptable.]]>Asemi, Z., S. Jazayeri, M. Najafi, M. Samimi and V. Mofid et al.,201114476482Garland, S.M., F. Ni Chuileannain, C. Satzke and R. Robins-Browne,200257169183Gojnic, M., A. Fazlagic, M. Pervulov, S. Petkovic, T. Mostic and K. Jeremic,200532114116Goldenberg, R.L., J.F. Culhane, J.D. Iams and R. Romero,20083717584Hemalatha, R., B.A. Ramalakshmi, S.S.Y.H. Quadri, N. Balakrishna, V.V. Annapurna and B. Sesikeran,200811824Guzick, D.S. and K. Winn,1985651116Holzman, C., X. Lin, P. Senagore and H. Chung,2007166786794Chavarria, V.I., P.S. Smith, M.M. Gonzalez, G.R. Pineda and S. Karchmer,198957203208Mostafa-Gharebaghi, P., M. Mansourfar and H. Sadeghi-Bazargani,201013946950Nowak, M., P. Oszukowski, M. Szpakowski, A. Malinowski and G. Maciolek-Blewniewska,199869615622Ratanakorn, W., W. Srijariya, S. Chamnanvanakij and P. Saengaroon,q200588973978Rudigoz, R.C.,20083612441244Saeedi, M., G.R. Veghari and A. Marjani,20071023592362Sheikhi, A.K., C. Tayade, V.A. Paffaro and B.A. Croy,20071028852889Trochez-Martinez, R.D., P. Smith and R.F. Lamont,2007114796801Van der Ham, D.P., R. van de Laar, B.W.J. Mol and C. Willekes,2008115127127Wiwanitkit, V.,200513179181Woldesenbet, M., C.R. Rosenfeld, O. Ramilo, S. Johnson-Welch and J.M. Perlman,200893F413F417Yoon, B.H., J.K. Jun, K.H. Park, H.C. Syn, R. Gomez and R. Romero,19968810341040Wu, Y.W. and J.M. Colford Jr.,200028414171424