Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.833.838AwangN. KamaludinN.F. HamidA. MokhtarN.W.N. RajabN.F. 1220121517Studies on the discovery of new cancer treatment by using metal-based compounds such as tin (Sn) has now greatly being synthesized and evaluated to identify their effectiveness and suitability to be developed as a new anticancer drug. Approach: This study was carried out to evaluate the cytotoxicity of triphenyltin(IV) methylisopropyldithiocarbamate (compound 1) and triphenyltin(IV) ethylisopropyldithiocarbamate (compound (2) on chronic myelogenus leukemia cells. The determination of their cytotoxicity (IC50) at different time of exposure and concentration was carried out through the employment of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay. Results: The IC50 values obtained for compound 1 and 2 following treatment at 24, 48 and 72 h were 0.660, 0.223, 0.370 μM and 0.677, 0.306, 0.360 μM, respectively. Cell morphological changes such as apoptotic and necrotic features were also been observed. Conclusion: The compounds tested were found to give cytotoxic effect against chronic myelogenus leukemia (K-562) cell at a micromolar dose. Thus, further study on their specific mechanism of actions in the human cells should be carried out to elucidate their potential as an anticancer agent.]]>Normah, A., K.N. Farahana, B. Ester, H. Asmah, N. Rajab and A.A. Halim,201115544549Bollo, E., R. Guglielmino, S. Sant, P. Pregel and F. Riondata et al.,200622275284Chikahisa, L., Y. Oyama, Y. Iguchi, E. Okazaki, N. Miyoshi, M. Satoh and Y. Yamada,19986209215Gessner, P.K. and T. Gessner,1992Pages: 452Pages: 452Gomez-Ruiz, S., G.N. Kaluderovic, S. Prashar, E. Hey-Hawkins, A. Eric, Z. Zizak and Z.D. Juranic,200810220872096Hatano, T., K. Ohkawa and M. Matsuda,1993in vitro.]]>14288294Hussain, S.A., Y.T. Ma and M.H. Cullen,20088771784Johnson, D.J., V. Amarnath, K. Amarnath, H. Valentine and W.M. Valentine,2003766574Kaludjerovic, G.N., H. Kommera, E. Hey-Hawkins, R. Paschke and S. Gomez-Ruiz,20102419428Hoti, N., J. Ma, S. Tabassum, Y. Wang and M. Wu,2003134521528Oh, W.K., M.H. Tay and J. Huang,2007109477486Pellerito, C., L. Nagy, L. Pellerito and A. Szorcsik,2006n+ complexes and parent compounds.]]>69117331747Salmon, S.E. and A.C. Sartorelli,20012001pp: 923-956pp: 923-956Sanuddin, M., Y. Farina, B.M. Yamin and I. Baba,200534107112Syng-ai, C., T.S.B. Baul and A. Chatterjee,2002in vitro and in vivo.]]>5134959Tian, L.J., Y.X. Sun, G.M. Yang, B.C. Qian and Z.C. Shang,2005in vitro antitumour activity of a novel binuclear organotin complex.]]>1615841586Pratt, W.B.,19942nd Edn.,pp: 69-235pp: 69-235Yip, F.W., Y. Farina, S.G. Teoh, S.H. Inayat-Hussain, B.M. Yamin, I. Baba and A.M. Ali,200642347Alama, A., B. Tasso, F. Novelli and F. Sparatore,200914500508