Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2012.854.862Oreochromis niloticus): A Light Microscope Study]]>KhidrBothaina M. MekkawyImam A.A. HarabawyAhmed S.A. OhaidaAbdel Salam M.I. 1220121518The adverse impacts of heavy metals on fish liver were evident with great variability among organs and species. The present study deals with the histological changes of the hepatocytes of the Nile tilapia, Oreochromis niloticus, following exposure to 2.5, 5, 10 ppm of lead nitrate for 1, 2, 3, 4 weeks. The present results revealed that lead nitrate exerts some histological effects on the hepatic tissue after exposure to the first concentration in the form of dilatation and congestion of the blood vessels, vacuolation of hepatic cells, proliferation of connective tissue and hepatic necrosis. Leucocyte aggregation-mostly lymphatic in nature-was seen infiltrating hepatic tissue. These alterations became more pronounced in liver of fishes exposed to second concentrations indicating more progressive signs of necrosis. The presence of eosinophilic oedematous areas surrounding some blood vessels was also observed. Finally, at the third concentration, in addition to the above alterations, melanomacrophages, which store lipofuscin at the site of necrosis, were observed. These histological results imply that the fish liver may serve as a target organ for the toxicity of sublethal concentrations of lead nitrate.]]>Abdel-Nasser, M., A.A. Shaaban, S.M. Aly and M.M. Sayed,1996346884Abdel-Nasser, M., A.A. Shaaban, S.M. Aly and M.M. Sayed,1996348594Abdel-Rahman, M.A.,19971997Agius, C.,19792337343Ahmed, M.A.,19961996Arnold, B.S., C.H. Jagoe, T.S. Gross, E.W. Howerth and R.E. Reinert,2000Oreochromis niloticus.]]>2000Aronson, A.L.,197161124128Bais, U.E. and M.V. Lokhande,2012Ophiocephalus striatus (Channa).]]>82332Baker, J.T.P.,1969Pseudopleuronectes americanus).]]>2627852793Bancroft, D. and A. Stevens,19822nd Edn.,Pages: 262Pages: 262Sylvie, B.R., C. Pairault, G. Vernet and H. Boulekbache,1996Oncorhynchus mykiss, sac-fry.]]>3320652079Fantin, A.M., A. Franchini, E. Ottaviani and L. Benedetti,1985Viviparus ater (Mollusca, Gastropoda).]]>29377387Braunbeck, T.,19921992Braunbeck, T., K. Gorgas, V. Storch and A. Volki,1987Leuciscus idus melanotus L.: Cyprinidae: Teleostei) during thermal adaptation.]]>175303313Bunton, T.E., S.M. Baksi, S.G. George and J.M. Frazier,1987Morone americana).]]>24515524Chandravathy, V.M. and S.L.V. Reddy,1996Anabas scandems.]]>177579Cheville, N.F.,19831983pp: 75-129pp: 75-129Davies, P.H., J.P. Goettl, Jr., J.R. Sinley and N.F. Smith,1976Salmo gairdneri in hard and soft water.]]>10199206De Zwaan, A. and D.I. Zandee,1972Mytilus edulis L.]]>434754El-Banhawy, M.A., S.M. Sanad, S.A. Sakr, I.A. El-Elaimy and H.A. Mahran,199317369393Franchini, A., E. Barbanti and A.M. Fantin,1991Carassius carassius (L.) Var auratus.]]>23893901Freeman, H.C., G. Sangalang and B. Fleming,1982Gadus morhua).]]>24111Gluth, G. and W. Hanke,1985Cyprinus carpio, induced by several pollutants at sublethal concentrations. I. The dependency on exposure time.]]>9179188Hanke, W., G. Gluth, H. Bubel and R. Muller,19837229241Hinton, D.E., J.E. Klaunig and M.M. Lipsky,1978404750Hussein, S.Y. and I.A.A. Mekkawy,2001Tilapia zillii.]]>306597Jiraungkoorskul, W., E.S. Upatham, M. Kruatrachue, S. Sahaphong, S. Vichasri-Grams and P. Pokethitiyook,2002Oreochromis niloticus).]]>28121127Khidr, B.M. and I.A.A. Mekkawy,2008Oreochromis niloticus).]]>56247269Khidr, B.M., I.A.A. Mekkawy, A.S. Harabawy and A.M. Ohaida,2008Oreochromis niloticus: Ultrastructural study.]]>5089119Kosai, P., W. Jiraungkoorskul, A. Synsatayakul and K. Jiraungkoorskul,20116346355Kranz, H. and N. Peters,1985Gynmocephalus cernua (L.), from the Elbe estuary.]]>81324Lamchumchang, K., W. Jiraungkoorskul, S. Sahaphong, T. Tansatit, P. Kosai and R. Madarasmi,2007Oreochromis niloticus).]]>2104114Lashein, F.E.,1999Cteuopharyngodon idella (Cuvier and Valenciennes, 1844).]]>32125140Matthiessen, P. and R.J. Roberts,19825153159McManus, J.F.A.,19482399108Mekkawy, I.A.A. and F.E. Lashein,2003Ctenopharyngodon idellus with emphasis on the corresponding morphological variations.]]>2003Mekkawy, I.A.A., U.M Mahmoud and A.T.A. Ibrahim,2008Oreochromis niloticus (Linnaeus, 1758) collected from three localities at Assiut, Egypt and the corresponding tissue damage.]]>5597127Mekkawy, I.A., U.M. Mahmoud and A.E.D.H. Sayed,2011Clarias gariepinus (Burchell, 1822).]]>43223229Mekkawy, I.A.A., U.M. Mahmoud, E.T. Wassif and M. Naguib,2012oreochromis niloticus (linnaeus, 1758).]]>7240265Mekkawy, I.A.A., U.M. Mahmoud, E.T. Wassif and M. Naguib,2011Oreochromis niloticus (Linnaeus, 1758) dietary supplemented with tomato paste and vitamin E.]]>377184Mekkawy, I.A.A., U.M. Mahmoud and A.T. Ibrahim,2007Bagrus bajad (Forsskal, 1775) collected from three localities at Assiut, Egypt.]]>54119137Mobarak, Y.M.S. and M.M. Sharaf,2011Poecilia latipinna).]]>7118Osman, A.G.M., I.A. Mekkawy, J. Verreth, S. Wuertz, W. Kloas and F. Kirschbaum,2008Clarias gariepinus (Burchell, 1822) after exposure to lead nitrate using alkaline comet assay.]]>23679687Osman, A.G.M., I.A. Mekkawy, J. Verreth and F. Kirschbaum,2007Clarias gariepinus (Burchell, 1822).]]>33113Osman, A.G.M., S. Wuertz, I.A. Mekkawy, H.J. Exner and F. Kirschbaum,2007Clarias gariepinus (Burchell, 1822).]]>22375389Pearse, A.G.E.,19602nd Edn.,Rizk, T., B.E. El-Sayed-Badawy and O.S. Sallam,1999Biomphalaria alexabdria (Gastropoda, Pulmonata).]]>32319337Robbins, S.L. and V. Kumar,19871987pp: 21-22pp: 21-22Roberts, R.J.,19751975pp: 399-422pp: 399-422Sayed, A.E.H., I.A.A. Mekkawy and U.M. Mahmoud,2012Clarias gariepinus (Burchell, 1822) Exposed to 4-Nonylphenol.]]>2012pp: 163-164pp: 163-164Sayed, A.E.D.H., U.M. Mahmoud and I.A. Mekkawy,2012Clarias gariepinus exposed to 4-nonylphenol.]]>78310319Segnini, B.M.I., H.G. Finol, J. Mediana, A. Boada-Sucre, S. Marcano and B. Bello,2000Colossoma macropomum (Cuvier, 1818) treated with a herbicide.]]>2000pp: 133144Shibamoto, T. and L.F. Bjeldanes,1993pp: 126-132pp: 126-132Taweel, A.K.A., M. Shuhaimi-Othman and A.K. Ahmad,2012Oreochromis niloticus) from four selected markets in Selangor, Peninsular Malaysia.]]>12138145Walter, J.B. and M.S. Israel,19744th Edn.,Weir, P.A. and C.H. Hine,1970204551Wood, E.M. and B.A. Yasutake,195632591603Wright, G.L., M.A. Lessler and S.G. Iams,1975in vitro steroid synthesis of the rat adrenal gland.]]>75155171Yamamoto, M. and N. Egami,1974Oryzias latipes.]]>13199210Yang, J.L. and H.C. Chen,200342455461Yuness, H.A.M.,20052005Sayed, A.E.D.H., I.A. Mekkawy and U.M. Mahmoud,2011Clarias gariepinus: Haematological, Biochemical, Histological and Molecular Characteristics of Clarias gariepinus Exposed to 4-Nonylphenol.]]>Pages: 240Pages: 240