Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.1046.1050TalghiniShahla ShenasiAbdollah 1220131619Pterygium is a common ocular lesion whose exact etiology is
a point of contention. Chronic inflammation and angiogenesis are two major proposed
mechanisms of the disease in the current literature. The objective of this study
is to examine these two mechanisms in a very well-designed setting. In a case-control
study, 24 tissue specimens from the patients with primary moderate pterygium
(cases) and 15 specimens excised from the nasal bulbar region in healthy counterparts
(controls) were compared in terms of the count of mast cells (inflammation),
as well as the status of Cd31/vascular Endothelial Growth Factor (VEGF) expression
(angiogenesis) in Tabriz Nikookari and Sina Teaching Hospitals. The case (mean
age: 58.08±10.03 years, 84% males) and control (Mean age: 62.33±9.19
years, 80% males) groups were age-and sex-matched (p = 0.19, 0.75, respectively).
The mean mast cell count was significantly higher in the case group (27.72±15.19
vs. 12.00±7.09 cells mm-2, p = 0.001). The study of immunoreactivity
revealed that the positive expression (moderate-severe) of CD31 was significantly
more frequent in the case group (88 vs. 26.7%; p<0.001; Odds ratio = 20,
95% confidence interval 3.85-100). There was also higher rate of VEGF-positive
(moderate-severe) cells in the group with pterygium (88 vs. 20%; p<0.001;
Odds ratio = 33.3, 95% confidence interval 5.00-100). This study indicates that
both inflammation and angiogenesis play pivotal role, in parallel, in pathogenesis
of pterygium.]]>Aspiotis, M., E. Tsanou, S. Gorezis, E. Ioachim, A. Skyrlas, M. Stefaniotou and V. Malamou-Mitsi,20072110951101Awdeh, R.M., J.J. DeStafeno, D.M. Blackmon, T.J. Cummings and T. Kim,200825479487Bazzazi, N., A. Ramezani and M.A.S. Rabiee,201013409412Beden, U., M. Irkec, D. Orhan and M. Orhan,200311115122Butrus, S.I., M.F. Ashraf, D.M. Laby, A.I. Rabinowitz, S.O. Tabbara and A.A., Hidayat,1995119236237Chui, J., N. Di Girolamo, M.T. Coroneo and D. Wakefield,20074844824489Chui, J., N. Di-Girolamo, D. Wakefield and M.T. Coroneo,200862443Detorakis, E.T. and D.A., Spandidos,200923439447Fukuhara, J., S. Kase, T. Ohashi, R. Ando and Z. Dong et al.,2013139381389Jackson, D.E.,2003540714Jasani, B. and K.W. Schmidt,19931st Edn., pp: 125-140pp: 125-140Jin, J., M. Guan, J. Sima, G. Gao and M. Zhang et al.,200322473477Lee, P.P., J.J. Hwang, L. Mead and M.M. Ip,20011887588Liang, Q.F., L. Xu, X.Y. Jin, Q.S. You, X.H. Yang and T.T. Cui,201012316991701Lin, H., L. Luo, S. Ling, W. Chen and Z. Liu et al.,201319166173Ling, S., L. Liang, H. Lin, W. Li and J. Xu,2012130735742Livezeanu, C., M.M. Craiţoiu, R. Manescu, C. Mocanu and S. Craitoiu,201152837844Mandour, S.S., H.G. Farahat and H.M. Mohamed,201127481485Marcovich, A.L., Y. Morad, J. Sandbank, M. Huszar and M. Rosner et al.,2002251722Nakagami, T., A. Murakami, S. Okisaka and N. Ebihara,1999437579Ribatti, D., B. Nico, C. Maxia, V. Longo and D. Murtas et al.,200711585589Ribatti, D., B. Nico, M.T. Perra, C. Maxia and F. Piras et al.,200990615620Van Setten, G., M. Aspiotis, T.D. Blalock, G. Grotendorst and G. Schultz,2003241135139Zhong, Y., K. Ding and W. Ye,200137455457