Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.1287.1294Ficus sur Forssk (Moraceae) in Rodents]]>O. IsholaIsmail O. OlayemiSunday K. YemitanOmoniyi K. EkpemandudiriNgozi 1220131621Ficus sur Forssk (Moraceae) is used in traditional
African medicine in the treatment of epilepsy, pain and inflammations. Anticonvulsant
activity was investigated using picrotoxin (PTX), strychnine (SCN), isoniazid
(INZ), pentylenetetrazole (PTZ) and N-methyl-D-aspartic acid NMDA models of
convulsion. The phytochemical analysis of the extract revealed the presence
of flavonoids, saponins, tannins, alkaloids and anthraquinone. Oral administration
of Ficus sur, 1 h before intraperitoneal injection of chemical convulsants
significantly (p<0.05) delayed the onset and prolonged the duration of convulsions
in PTX, SCN, INZ, PTZ and NMDA-induced seizures. However, the anticonvulsant
activity of the ethanolic extract of Ficus sur was significantly reversed
following intraperitoneal pre-treatment with flumazenil (GABA receptor antagonist),
cyproheptadine (5-HT2 receptor antagonist) and L-NNA (nitric oxide
synthase inhibitor) in picrotoxin-induced convulsion. The data obtained suggest
that ethanol extract of Ficus sur possessed significant anticonvulsant
effect, thereby confirming the traditional uses of Ficus sur in the treatment
of epilepsies; mechanisms of which could involve interaction with GABAergic,
glycinergic, serotonergic and glutaminergic system barks.]]>Adeyemi, O.O., O.K. Yemitan and O.A. Olayemi,2007Sanseviera liberica Gerome and Labroy (Agavaceae).]]>113111114Bernasconi, R., M. Klein, P. Martin, P. Christen, T. Hafne, C. Portet and M. Schmutz,198872213233Chapman, A.G. and B.S. Meldrum,199321106110Costa, E., A. Guidotti and C.C. Mao,19751975pp: 113-151pp: 113-151Dhir, A.,201014109115Gale, K.,19922264277Gupta, G., I. Kazmi, M. Afzal, M. Rahman and S. Saleem et al.,2012Viscum album L. (Loranthaceae) in mice and rats.]]>141810816Igoli, J.O., O.G. Ogaji, T.A. Tor-Anyiin and N.P. Igoli,20052134152Marcus, R. and A.M. Coulsto,19851985pp: 1551-1572pp: 1551-1572McNamara, J.O.,20062006pp: 501-525pp: 501-525Michael, A.R.,200669273294Mujumdar, A.M., D.G. Naik, R.J. Waghole, D.K. Kulkarni and M.S. Kumbhojkar,2000Sterculia foetida leaves.]]>381317Nicoll, R.A.,20012001pp: 351-363pp: 351-363NIH,19851985Nogueira, E. and V.S. Vassilieff,2000Rubus brasiliensis. Involvement of GABAA-system.]]>70275280Ojokuku, S.A., W.O. Okunowo and A. Apena,2010Khaya grandifoliola and Ficus capensis.]]>411261129Olowokudejo, J.D., A.B. Kadiri and V.A. Travih,200812851865Owolabi, O.J., Z.A. Nworgu, A. Falodun, B.A. Ayinde and C.N. Nwako,2009Ficus capensis Thunb. (Moraceae).]]>66293296Oyeleke, S.B., B.E.N. Dauda and O.A. Boye,2008Ficus capensis.]]>714141417Paul, V. and E.H. Subramanian,200272515519Perazzo, F.F., J.C.T. Carvalho, J.E. Carvalho and V.L.G. Rehder,2003Artemisia annua.]]>48497502Rang, H.P., M.M. Dale and J.M. Ritter,20004th Edn.,pp: 604-613pp: 604-613Trease, G.E. and W.C. Evans,198913th Edn.,Pages: 585Pages: 585Velisek, L.,20062006pp: 127-152pp: 127-152Vogel, H.G. and W.H. Vogel,19971997pp: 267-268pp: 267-268Watkins, J.C. and R.H. Evans,198121165204WHO,20122012Wood, J.D. and S.J. Peesker,197320379387