Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.1324.1329RodriguesM.M.P. RemaA. GartnerM.F. Laufer-AmorimR. 1220131621E-cadherin and beta-catenin are component of adherens junctions
in epithelial cells. Loss of these proteins have been associated with progression
of prostatic diseases. We performed immunohistochemistry for E-cadherin, beta-catenin
and Ki-67 on canine prostatic lesions. We analyzed the expression of these antibodies
in benign prostatic hyperplasia (BPH, n = 22), in pre neoplastic lesions Prostatic
Intra-epithelial Neoplasia (PIN), n = 3 and Prostatic Inflammatory Atrophy (PIA),
n = 7 and prostate carcinoma (PC, n = 10). In this study, a membranous expression
of E-cadherin and beta-catenin and nuclear expression of Ki-67 antigen were
demonstrated. The proliferative index was statistically different between carcinomas
and BPH and carcinomas and pre-neoplastic lesions. Like in men, the reduction
of E-cadherin and increase of Ki-67 expression in neoplastic lesions in dog
prostate may be related to the carcinogenic process in this gland.]]>Asgeirsson, K.S., J.G. Jonasson, L. Tryggvadottir, K. Olafsdottir, J.R. Sigurgeirsdottir, S. Ingvarsson and H.M Ogmundsdottir,20003610981106Bostwick, D.G.,19971997pp: 343-421pp: 343-421De Marzo, A.M., V.L. Marchi, J.I. Epstein and W.G. Nelson,199915519851992Foster, R.A. and P.W. Ladds,20072007pp: 590pp: 590Gounari, F., S. Signoretti, R. Bronson, L. Klein and W.R. Sellers et al.,20022140994107Horvarth, L.G., S.M. Henshall, C.S. Lee, J.G. Kench and D. Golovsky et al.,2005113415422Huang, S.P., W.C. Ting, L.M. Chen, L.C. Huang and C.C. Liu et al.,201017312322Jaggi, M., S.L. Johansson, J.J. Baker, L.M. Smith, A. Galich and K.C. Balaji,200523402406Lai, C.L., R. Van den Ham, G. van Leenders, J. van der Lugt and E. Teske,200868498507Matos, A.J.F., C. Lopes, J. Carvalheira, M. Santos, G.R. Rutteman and F. Gartner,2006134182189Matos, A.J.F., C.C.C. Lopes, A.M.R. Faustino, J.G.V. Carvalheira, G.R. Rutteman and M.D.F.R.M. Gartner,2007115327334Mol, A.J.M., A.A. Geldof, G.A. Meijer, H.G. van der Poel and R.J.A. van Moorselaar,2007133687695Nowak, M., J.A. Madejand and P. Dziegiel,200745233238Pontes-Junior, J., S.T. Reis, M. Dall'Oglio, L.C.N. de Oliveira and J.Cury et al.,20092009Saha, B., A. Arase, S.S. Imam, D. Tsao-Wei and W.Y. Naritoku et al.,2008687884Verras, M. and Z. Sun,20062372232Toledo, D.C., M.B.R. Faleiro, M.M.P. Rodrigues, G.W. Di Santis, R. Laufer-Amorim and V.M.B.D. de Moura,20104013721377Whitaker, H.C., J. Girling, A.Y. Warren, H. Leung, I.G. Mills and D.E. Neal,20086811961205