Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.2050.2053IssaMahmoud MohamedNejemR`afat MahmoudShanabAlaa Abu1220131624Paracetamol has been reported to chelate with iron. It was
found that no in vitro reaction between ferrous ion and paracetamol.
Other studies found that there is an aerobic (in the gastrointestinal tract)
oxidation of ferrous ion to ferric ion caused in iron-paracetamol in vivo
reactions. The objective of this study was to determine if iron interacts with
paracetamol and reduces paracetamol absorption. A randomized, double-blind,
cross-over study design was used to assess the in vivo interaction of
paracetamol and ferrous ion. Paracetamol (1.0 g) was co-ignested alone or with
(300 mg) ferrous sulphate by ten healthy male volunteers, using saliva drug
levels as a parameter. Concomitant administration of ferrous sulphate and paracetamol,
decreased AUC8 from 42.88±3.8-34.25±2.8 μg h mL-1
(p = 0.04) and Cmax from 18.75±1.9 to 15.9±1.7 μg
mL-1 (p = 0.11), while no change in tmax (p = 0.5) was
originated. A significant difference was found in the paracetamol pharmacokinetic
parameter oral clearance (Cl/F) (p = 0.02) and slightly increased in volume
of distribution (Vd/F) (p = 0.10). Co-administration of iron and
paracetamol results in decreased paracetamol absorption due to an interaction
between iron and paracetamol.]]>Campbell, N.A. and B. Hasinoff,198945220225Campbell, N.R., M. Kara, B.B. Hasinoff, W.M. Haddara and DW. Mckay,199233115116Campbell, N.R., D. Rankine, A.E. Goodrige, B.B. Hasinoff and M. Kara,199130559605Moffat, A.C., M.D. Osselton, B. Widdop and J. Watts, 2011Pages: 1856Pages: 1856Issa, M.M., R.M. Nejem, N.S. El-Abadla, M.H. Al-Kholy and A.A. Saleh et al.,200870334350Jie, N., X. Yang, R. Zhang and Z. Song,19954215751580Kara, M., B.B. Hasinoff, D.W. Mckay and N.R. Cambell,199131257261Liu, T.Z. and K.H. Oka,1980266971Lorenz, M., M. Wolzt, G. Weigel, H. Puttinger and W.H. Horl et al.,20044310981103Morii, M., K. Ueno, A. Ogawa, R. Kato and H. Yoshimura et al.,200086613616Neuvonen, P.S., G. Gothoni, R Hackman and K. Bjorksten,19704532534Osman, M.A., R.B. Patel, A. Schuna, W.R. Sundstroom and P.G. Welling,198333465470Schaefer, J.P., Y. Tam, B.B. Hasinoff, S. Tawfik, Y. Peng, L. Reimche and N.R. Campbell,199846377381Solomons, N.W. and R.A. Jarob,198134427482Sunagane, N., E. Yoshibu, N. Murayama, Y. Terawaki and T. Uruno,2005125197203Vilchez, J., R. Blanc, R. Navidad and A. Navalon,199513011191125