Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2013.401.411RashidiAli Akbar MirhashemiSeyyed Mehdi TaghizadehMohsen SarkhailParisa 92013169In the Iranian traditional medicine a significant usage of herbs is promoted for their anti-diabetic activity. The aim of this review to assess the efficacy of glucose lowering effects of medicinal plants cultivated in Iran. An electronic literature search of MEDLINE, Science Direct, EMBASE, Scopus, Web of Science, Cochrane Library Database, Ebsco and Google Scholar from database inception conducted up to May 2012. A total of 85 studies (18 humans and 67 animals) examining 62 plants were reviewed. The quality of Randomized Controlled Trials (RCTs) assessed by using the Jadad scale. Among the RCTs studies, the best results in glycemic control was found in Aloe vera, Citrullus colocynthus, Plantago ovata, Silybum marianum, Rheum ribes and Urtica dioica. The majority of plants that have been studied for antidiabetic activity showed promising results. However, efficacy and safety of the most plants used in the treatment of diabetes are not sufficient.]]>Abdollahi, M., A. Salehnia, S.H. Mortazavi, M. Ebrahimi and A. Shafiee et al.,2003Satureja Khuzestanica in rat in vivo: A oxicopharmacological study.]]>9331335Akhlaghi, F., Z. Rajaei, M.A.R. Hadjzadeh, M. Iranshahi and M. Alizadeh,201217157162Asgary, S., S. Parkhideh, A. Solhpour, H. Madani, P. Mahzouni and P. Rahimi,200811533538Avizeh, R., H. Najafzadeh, M. Pourmandi and M. Mirzaee,20108109113Bnouham, M., F.Z. Merhfour, A. Ziyat, H. Mekhfi, M. Aziz and A. Legssyer,2003Urtica dioica.]]>74677681Chan, C.H., G.C. Ngoh and R. Yusoff, 201262228Eidi, A. and M. Eidi,2009Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats.]]>34044Eidi, A., M. Eidi and R. Darzi,2009Olea europaea L. in normal and diabetic rats.]]>23347350Eidi, A., M. Eidi, M.H. Givian and N. Abaspour,20098105112Eidi, M., A. Eidi, A. Saeidi, S. Molanaei, A. Sadeghipour, M. Bahar and K. Bahar,2009Coriandrum sativum L.) ethanol extract on insulin release from pancreatic β cells in streptozotocin-induced diabetic rats.]]>23404406Eidi, A., M. Eidi, S. Oryan, F. Fallahyan and R.D. Darounkala,2004Olea europaea L.) leaf in healthy and diabetic rats.]]>33640Eidi, A., M. Eidi, P. Shahmohammadi, V. Mozaffarian, A. Rustaiyan and A. Mazooji,201176673Eidi, A., M. Eidi and E. Esmaeili,2006Allium sativum L.) in normal and streptozotocin-induced diabetic rats.]]>13624629Eidi, A., M. Eidi and M. Sokhteh,2006Trigonella foenum graceum L.) in the activity of hepatic enzymes in normal and diabetic rats.]]>53641Eidi, M., A. Eidi and H. Zamanizadeh,2005Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats.]]>100310313Eidi, M., F. Soleimani and S. Ebrahimi,2007Allium porrum L. leaves in healthy and streptozotocin-induced diabetic mice.]]>68591Esmaeili, M.A. and R. Yazdanparast,2004Teucrium polium: Studies with rat pancreatic islets.]]>12730Estakhr, J. and N. Javdan,20113354360Fallah Hoseini, H., B. Larijani, H. Fakhrzadeh, S. Akhondzadeh, B. Rajabipour, T. Toliat and R. Heshmat,200437878Fallah Huseini, H., R. Heshmat, F. Mohseni, A.H. Jamshidi, S.H.A. Alavi, M. Ahvasi and B. Larijani,2008279297Fallah Huseini, H., P. Hooseini, R. Heshmat, D. Yazdani and R. Hemati Moqadam et al.,2006Securigera securidaca (L.) (Degen and Doerfler) seeds in type II diabetic patients: A randomized, double-blind, placebo-controlled study.]]>57579Fallah Huseini, H., B. Larijani, B. Raajabipour and R. Heshmat,200541317Fallah Huseini, H., A. Zaree, R. Heshmat, A.L.M. Bagher and H. Fakhrzadeh et al.,2006Citrullus colocynthis (L.) Schrad. fruit on oxidative stress parameters in type II diabetic patients.]]>55560Fazeli, S.A., A.M. Gharravi, S. Ghafari, M. Jahanshahi and M.J. Golalipour,2008Urtica dioica extract on young diabetic rats.]]>67196204Feshani, A.M., S.M. Kouhsari and S. Mohammadi,2011Vaccinium arctostaphylos, a common herbal medicine in Iran: Molecular and biochemical study of its antidiabetic effects on alloxan-diabetic Wistar rats.]]>1336774Golalipour, M.J., A.M. Gharravi, S. Ghafari and M. Afshar,20071038753879Haidari, F., N. Seyed-Sadjadi, M. Taha-Jalali and M. Mohammed-Shahi,201132695700Haidari, F., M.M. Shahi, M. Zarei, H. Rafiei and K. Omidian,201233128133Hajzadeh, M.A.R., Z. Rajaei, G. Ghamami and A. Tamiz,20111213220Hajzadeh, M.A.R., Z. Rajaei, S. Shafiee, A. Alavinejhad, S. Samarghandian and M. Ahmadi,20111809817Hannan, J.M., L. Ali, J. Khaleque, M. Akhter, P.R. Flatt and Y.H. Abdel-Wahab,2006Plantago ovate reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption.]]>96131137Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,20084, 3285292Hedayati, M., I. Pouraboli and B. Pouraboli,2010Otostegia persica on serum levels of glucose and lipids in type I diabetic male rats.]]>12435442Hedayati, M., I. Pouraboli, B. Pouraboli, S. Dabiri and A. Javadi,2012Otostegia persica extract on serum level of glucose and morphology of pancreas in diabetic rats.]]>13201208Heidarian, E. and Y. Soofiniya,2011Cynara scolymus in streptozotocin-induced diabetic rats.]]>527172723Hoseini, H.F., A.R. Gohari, S. Saeidnia, N.S. Majd and A. Hadjiakhoondi,2009Nasturtium officinale on blood glucose level in diabetic rats.]]>3866871Hoseini, H.F., S. Saeidnia, A.R. Gohari, M.H. Yazdanpanah and A. Hadjiakhoondi,20093732736Hosseinzadeh, H., M. Khodaparast and H. Shokoohizadeh,1998Salvia leriifolia Benth. leaf and seed extracts in mice.]]>49498Hosseinzadeh, H. and A. Sadeghi,1999Morus nigra and Morus alba in mice.]]>96365Huseini, H.F., F. Darvishzadeh, R. Heshmat, Z. Jafariazar, M. Raza and B. Larijani,2009Citrullus colocynthis (L.) schrad fruit in treatment of type II diabetic patients: A randomized, double blind, placebo-controlled clinical trial.]]>2311861189Huseini, H.F., S. Kianbakht, R. Hajiaghaee and F.H. Dabaghian,201278311316Jadad, A.R., R.A. Moore, D. Carroll, C. Jenkinson, D.J. Reynolds, D.J. Gavaghan and H.J. McQuay,199617112Jadidoleslami, M., M.A. Nejad and M.R. Shahraki,20062006Javdan, N. and J. Estakhr,20112874878Jelodar, G., M. Mohsen and S. Shahram,20074299305Kalantari, H., Z. Shahshahan, S.M. Hejazi, T. Ghafghazi and V. Sebghatolahi,201116287290Kamyab, H., S. Hejrati, M. Khanavi, F. Malihi and A. Mohammadirad et al.,20105304309Kasabri, V., F.U. Afifi and I. Hamdan,2011In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine.]]>133888896Kassaian, N., L. Azadbakht, B. Forghani and M. Amini,2009793439Kianbakht, S. and H. Fallah Huseini,2008Opuntia ficus-indica L. fruit on blood glucose level in streptozocin induced diabetic rats.]]>77178Madani, H., N.A. Mahmoodabady and A. Vahdati,2005Anethum graveolens (Dill) on plasma glucose an lipid levels in diabetes induced rats.]]>5116119Mahmoodabadi, N.A., H. Madani, P.V. Mahzooni and A. Vahdati,2006Cynara scolymus extract on appearance of type 1 diabetes mellitus in male rats.]]>2006Masjedi, F. and A. Gol and S.H. Dabiri,20109124135Mehri, A., S. Hasani-Ranjbar, B. Larijani and M. Abdollahi,2011Urtica dioica in the treatment of diabetes.]]>7161170Minaiyan, M., B. Zolfaghari and A. Kamal,2011Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats.]]>14436442Mirbadalalzadeh, R. and Z. Shirdel,20105145147Mirzaei, K., A. Hossein-Nezhad, M. Karimi, M.J. Hosseinzadeh-Attar, N. Jafari, A. Najmafshar and B. Larijani,2009173844Modak, M., P. Dixit, J. Londhe, S. Ghaskadbi and T.P.A. Devasagayam,200740163173Mohammadi, J., K. Saadipour, H. Delaviz and B. Mohammadi,2011Juglans regia in an animal model.]]>41685691Mohammadi, S., S.M. Kouhsari and A.M. Feshani,2010Rhus coriariafruits in rats]]>18270275Movahedian, A., B. Zolfaghari, S.E. Sajjadi and R. MoknatjouI,2010Peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats.]]>65629633Mozaffari-Khosravi, H., B.A. Jalali-Khanabadi, M. Afkhami-Ardekani and F. Fatehi,2009Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes.]]>15899903Najafi, S., B. SadeghiNejad, S.S. Deokule and J. Estakhr,2010Bidaria khandalense (Sant.) Loranthus capitellatus Wall., Viscum articulatum Burm. f. and Vitex negundo Linn.]]>1388393Najafzadeh, H., N. Aghel, A.A. Hemmati and S. Oulapour,2011Punica granatum on experimental diabetes mellitus by streptozotocin in rats.]]>16239248Naseri, M., S.Z. Khalaj, B. Ghavami, M.K. Nejad, G.A. Naderi and S. Faghihzadeh,2010Hordeum vulgare L.) seed extract on fasting serum glucose level in streptozotocin induced diabetic rats.]]>95766Nickavar, B. and N. Yousefian,20116191195Nikbakht, A., M. Kafi and M. Haghighi,2008790259262Nmila, R., R. Gross, H. Rchid, M. Roye and M. Manteghetti et al.,2000Citrullus colocynthis fruit extracts.]]>66418423Parastouei, K., S. Ravanshad, H. Mostaphavi and E. Setoudehmaram,200654854Patel, D.K., R. Kumar, D. Laloo, S. Hemalatha,20122411420Rahimi, P., N. Kabiri, S. Asgary and M. Setorki,2011526552661Rashidi, A.A. and M. Noureddini,20111372379Roghani, M. and M. Aghaie,200787378Roghani M., T. Baluchnejadmojarad and S. Taheri,20077153158Saeed, S., H. Mosa-Al-Reza, A.N. Fatemeh and D. Saeideh,201286572Safiyeh, S., F. Baijani Fathallah, N. Vahid, N. Hossine and S. Sadee Habib,2007Equisetum arvense L. (Equisetaceae) in streptozotocin-induced diabetes in male rats.]]>1016611666Sarkhail, P.,2011610341036Sarkhail, P., M. Abdollahi, S. Fadayevatan, A. Shafiee and A. Mohammadirad et al.,20106219224Sarkhail, P., S. Rahmanipour, S. Fadyevatan, A. Mohammadirad and G. Dehghan et al.,2007Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.]]>56261266Sedaghat, R., M. Roghani, M. Ahmadi and F. Ahmadi,2011Rumex patientia seed preparation in streptozotocin-diabetic rats.]]>18111115Asgary, S., S.J. Moshtaghian, M. Setorki, S. Kazemi, M. Refieian-Kopaei, A. Adelnia and F. Shamsi,2011Cucurbita pepo L.) on alloxan-induced diabetic rats.]]>526202626Shahaboddin, M.E., M. Pouramir, A.A. Moghadamnia, H. Parsian, M. Lakzaei and H. Mir,2011Pyrus biossieriana Buhse leaf extract: An antioxidant, antihyperglycaemic and antihyperlipidemic agent.]]>12617301733Shahraki, M.R., M.R. Arab, E. Mirimokaddam and M. Jey Palan,2006116568Shahsavari, R., A. Ehsani-Zonouz, M. Houshmand, A. Salehnia, G. Ahangari and M. Firoozrai,2009Satureja khuzestanica jamzad essential oil in diabetic rats: Role of decreased gluconeogenesis.]]>12140145Shamsi, F., S. Asgari, M. Rafieian, S. Kazemi and A. Adelnia,2011Cornus mas L. on blood glucose, insulin and histopathology of pancreas in alloxan-induced diabetic rats. ]]>29929938Shirdel, Z., H. Madani and R. Mirbadalzadeh,2009Ziziphus Jujuba Leaves on blood glucose and lipids in Alloxan-Induced diabetes in rats.]]>81319Solati, J. and N. Soleimani,2010Ziziphus vulgaris L. on streptozocin-induced [corrected] diabetic adult male Wistar rats.]]>47219223Soleimani, S., F.F. Azarbaizani and V. Nejati,2007Equisetum arvense L. (Equisetaceae) in histological changes of pancreatic β-cells in streptozotocin-induced diabetic in rats.]]>1042364240Soto, C., J. Perez, V. Garcia, E. Uria, M. Vadillo and L. Raya,20101710901094Esfanjani, A.T., N. Namazi and A. Bahrami,201213449458Tarighat, E.A., N. Namazi, A. Bahrami and M. Ehteshami,201213561568Teimoori, M., K.S. Montaser, R. Ghafarzadegan and R. Hajiaghaee,20109142149Vosough-Ghanbari, S., R. Rahimi, S. Kharabaf, S. Zeinali and A. Mohammadirad et al.,2010Satureja khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with type 2 diabetes mellitus: A double-blind randomized controlled trial.]]>7465470Williamson, G., P. Coppens, L. Serra-Majem and T. Dew,20112753759Yazdanparast, R., A. Ardestani and S. Jamshidi,2007Achillea santolina: Effect on pancreatic oxidative parameters.]]>1121318Yazdanparast, R., M.A. Esmaeili and J.A. Helan,2005Teucrium polium extract effects pancreatic function of streptozotocin diabetic rats: A histopathological examination.]]>98185Yeh, G.Y., D.M. Eisenberg, T.J. Kaptchuk and R.S. Phillips,20032612771294Zahedi-Asl, S., F. Saharnaz, A. Ghassemi and B. Zaree,20065916Ziai, S.A., B. Larijani, S. Akhoondzadeh, H. Fakhrzadeh and A. Dastpak et al.,2005102202207Ziaei, S.A., A.L.M. Bagher, H. Fakhrzadeh, A. Dastpak F. Bandarian, A. Rezaei and N. Badi,2004Plantago ovate L.) effects on diabetes and lipidemia in the Iranian type II diabetic patients.]]>34150Huseini, H.F., B. Larijani, R. Heshmat, H. Fakhrzadeh, B. Radjabipour, T. Toliat and M. Raza,2006Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: A randomized, double-blind, place bo-controlled, clinical trial.]]>2010361039Al-Ghaithi, F., M.R. El-Ridi, E. Adeghate and M.H. Amiri,2004Citrullus colocynthis in normal and diabetic rats.]]>261143149