Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2019.393.399ZareiElham MohajeryHassan AliakbariFatemeh ZadehFatemeh Mohammad VeghariGholamreza MansourianAzadreza 82019228Background and Objective: Polycystic ovary syndrome (PCOS) is shown to be associated with hyperandrogenemia and has some features such as cytotoxic T-cells activation and release of perforin and granzyme-B. Present work was aimed to investigate the relation of perforin and granzyme-B to androgenic state in PCOS. Materials and Methods: Forty three PCOS and 40 control women were recruited. After recording demographic data, sex hormone status and cardiovascular disease (CVD) risk factors were evaluated. Perforin and granzyme-B levels were measured using sandwich ELISA kits. Results: Sex hormone binding globulin (SHBG) levels were lower in patients. Luteinizing hormone (LH), free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), free androgen index (FAI), perforin and granzyme-B values were higher in PCOS group. Perforin and granzyme-B were positively correlated with FT and FAI and with each other in PCOS group. In patients, granzyme-B and perforin were related with FT and FAI, respectively. Conclusion: The results of present study together with evidences about the release of pro-inflammatory cytokines in insulin resistance, CVD and PCOS suggest that perforin/granzyme-B may be involved in interactions of sex hormones system in PCOS patients.]]>Mohammad, M.B. and A.M. Seghinsara,2017181721Rao, U. and R. Homburg,20182018pp: 23-30pp: 23-30Dumont, A., G. Robin, S. Catteau-Jonard and D. Dewailly,20152015Oztas, E., S. Ozler, A. Tokmak, N. Yilmaz and H.T. Celik et al.,20161988993Tsikouras, P., L. Spyros, B. Manav, S. Zervoudis and C. Poiana et al.,20158291296Shukla, A. and L. Mandel,20192019pp: 31-40pp: 31-40Reschke, L.D., A.M. Eskew and E.S. Jungheim,2019111e44e45Moro, F., A. Morciano, A. Tropea, F. Sagnella and C. Palla et al.,2012+ CD28null T lymphocyte frequency, a new marker of cardiovascular risk: relationship with polycystic ovary syndrome phenotypes.]]>9816091615Mansourian, A.R.,2012155867Mansourian, A.R., 20101310661076Mansourian, A.R.,201013765774Mansourian, A.R.,201013866876Mansourian, A.R.,201114170181Mansourian, A.R.,201114313326Mansourian, A.R.,201114412424Oztas, E., S. Ozler, A. Tokmak, N. Yilmaz, N. Danisman, M. Ergin and H.I. Yakut,2015104e127e127Anupam, K., J. Kaushal, N. Prabhakar and A. Bhatnagar,2018223586597Bhela, S., C. Kempsell, M. Manohar, M. Dominguez-Villar and R. Griffin et al.,2015hiCD127lo Tregs in multiple sclerosis and in response to IL-6.]]>19421802189Saito, Y., H. Kondo and Y. Hojo,201157141147Dutta, D., I. Park, H. Guililat, S. Sang, A. Talapatra, B. Singhal and N.C. Mills,201751193204Niccoli, G., R. Apa, A. Lanzone, G. Liuzzo and C. Spaziani et al.,2011+ CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome.]]>9526512654Yadav, A.K., V. Kumar and V. Jha,2013+ CD28null cells in chronic kidney disease.]]>2013Sun, Z., H. Ye, B. Tang, X. Shen, X. Wu, H. Zhong and W. Song,2013+ CD28null T cells is associated with early atherosclerotic damage in patients with end-stage renal disease undergoing hemodialysis.]]>74613Giubilato, S., G. Liuzzo, S. Brugaletta, D. Pitocco and F. Graziani et al.,2011+ CD28null T-lymphocytes in diabetic patients: Exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitus.]]>3212141226Yang, H., Y.H. Youm, B. Vandanmagsar, A. Ravussin and J.M. Gimble et al.,201018518361845Fauser, B.C., B.C. Tarlatzis, R.W. Rebar, R.S. Legro and A.H. Balen et al.,2012271424Jellinger, P., D. Smith, A. Mehta, O. Ganda and Y. Handelsman et al.,201218178Wild, R.A., E. Carmina, E. Diamanti-Kandarakis, A. Dokras and H.F. Escobar-Morreale,20109520382049Al-Shirbiny, M.F.M., K.M. Salama and A.R.A. Al-Said,20174+ CD28null in cases of polycystic ovary syndrome.]]>34146151Shorakae, S., S. Ranasinha, S. Abell, G. Lambert, E. Lambert, B. de Courten and H. Teede,201889628633Campbell, R.A., Z. Franks, A. Bhatnagar, J.W. Rowley and B.K. Manne et al.,2018200295304Ruggio, A., D. Pedicino, D. Flego, R. Vergallo and A. Severino et al.,2019+ CD28null T lymphocytes, regulatory T cells and plaque rupture: An optical coherence tomography study in acute coronary syndromes.]]>276289292Thomas, H.E., J.A. Trapani and T.W.H. Kay,201017577585Malin, S.K., J.P. Kirwan, C.L. Sia and F. González,2015308E770E777Li, W., Q. Chen, Y. Xie, J. Hu, S. Yang and M. Lin,201990138144Carmina, E., R. Azziz, W. Bergfeld, H.F. Escobar-Morreale and W. Futterweit et al.,201910428752891Firmansyah, A., M.T. Chalid, R.B. Farid and N. Nusratuddin,201816679682Zhang, B., J. Wang, S. Shen, J. Liu and J. Sun et al.,20182018Hiebert, P.R., W.A. Boivin, H. Zhao, B.M. McManus and D.J. Granville,20132013