Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2020.1201.1209Gongronema latifolium Aqueous Leaf Extract During Lactation May Improve Metabolic Homeostasis in Young Adult Offspring]]>KatchyA.N. IyareC.O. AdeniyiB.D. OkonkwoV.O. OdamaR.I. EzehC.O. IyareE.E. 92020239Background and Objective: Medicinal plants constitute a fundamental component of the traditional healthcare system in rural communities throughout Africa and Gongronema latifolium (GL), is widely trusted in Nigeria to have strong nutritional and medicinal values. This study was done to determine the effect of maternal consumption of GL during lactation in young adult offspring. Materials and Methods: Twenty four female albino Wistar rats were used for this study and were randomly assigned to four (4) groups. Group I: Control, Group II, 100 mg kg1, III, 200 mg kg1 and IV: 400 mg kg1 at delivery. The extract was administered orally and daily throughout lactation. Results: At postnatal day 42, offspring of extract-treated groups showed a dose-related significant decrease (p<0.05) in body weight, food intake, glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and a significant increase in liver weight index, pancreatic weight index, high-density lipoprotein cholesterol (HDL-C) and insulin concentrations of the offspring when compared with control in both sexes. Histological examination showed that GL extract caused histological alterations of the liver structures with various changes in the size of the sinusoids, with mild inflammatory cells without hepatotoxicity and cellular multiplication when compared with control. Conclusion: This study suggested that consumption of GL extract by lactating dams may improve metabolic homeostasis in young adult offspring.]]>JideFaleye, F. and A.M. Olatunya,2016419151919Bodeker, G., C.K. Ong, C.K. Grundy, G. Burford and K. Shein et al.,20051st Edn.,Akinyemi, K.O., O. Oladapo, C.E. Okwara, C.C. Ibe and K.A. Fasure,2005Staphylococcus aureus activity.]]>2005Okpala, B.,20152015Owu, D.U., C.R. Nwokocha, A.O. Obembe, A.D. Essien, D.E. Ikpi and E.E. Osim,2012Gongronema latifolium ethanol leaf extract on gastric acid secretion and cytoprotection in streptozotocin-induced diabetic rats.]]>61853860Essien, J.P., G.A. Ebong and E.J. Akpan,2007Gongronema latifolium leaves used locally for the treatment of fowl cough in Nigeria.]]>114750Barouki, R., P.D. Gluckman, P. Grandjean, M. Hanson and J.J. Heindel,2012114242Koletzko, B.,200517381382Holy, B., T. Davies and T.N. Imomoemi,2016Gongronema latifolium extracts on streptozocin induced diabetes in rats.]]>46269Bellinger, L., D.V. Sculley and S.C. Langley-Evans,200630729738Burstein, M., H.R. Scholnick and R. Morfin,197011583595WMA and APS,2002283R281R283Jovanovic, L.,20044266272Usoh, I.F. and E.O. Akpanyuyng,2015Gongronema latifolium and Ocimum gratissimum
offer synergy on organ weights alleviation and pancreatic resurgence
against Streptozotocin diabetic rats.]]>2522536Nwaka, A.C., P.A. Amu, P.A. Ikeyi and D.C. Okoye,2015Gongronema latifolium (Utazi) and
Vitex doniana (Uchakiri) leaves on the body weight and lipid profile of wistar albino rats.]]>10126130Kim, J.H., D.H. Hahm, D.C. Yang, J.H. Kim, H.J. Lee and I. Shim,200597124131Chung, K.T., T.Y. Wong, C.I. Wei, Y.W. Huang and Y. Lin,199838421464Islam, M.A., M.A. Akhtar, M.R. Khan, M.S. Hossain and A.H. Alam et al.,2009Coccinia cordifolia L. and Catharanthus roseus L.]]>22402404Igile, G., I. Iwara, O. Ekpe, B. Mgbeje and M. Eteng,2017Gongronema latifolium reverses Dyslipidemia and catalyzes glucokinase in lowering blood glucose sugar in streptozocin-induced diabetic rats.]]>14112Ugochukwu, N.H., N.E. Babady, M. Cobourne and S.R. Gasset,2003Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats.]]>2815Khunti, K. and M.J. Davies,20133012Arca, M., A. Montali, S. Valiante, F. Campagna and G. Pigna et al.,200710015111516Haralampidis, K., M. Trojanowska and A.E. Osbourn,2002753149Francis, G., Z. Kerem, H.P. Makkar and K. Becker,200288587605