Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2020.922.930Juniperus phoenicea L. Leaves Extract against Gamma-irradiation-induced Oxidative Stress]]>S. DessokyEldessoky IsmailIsmail A. El-HallousEhab I. F. AlsanieWalaa 72020237Background and Objective: Radiation exposure can cause several harmful effects in biological systems due to free radical production. Several antioxidants have been tested as potential hepatoprotective agents against ionizing radiation as they lower oxidative stress in normal cells induced by Reactive Oxygen Species (ROS). The present study was conducted to evaluate the possible ameliorative effects of Juniperus phoenicea L. Materials and Methods: Aqueous leaves extract on different biochemical and histopathological parameters against whole body gamma-irradiation-induced oxidative stress, organ dysfunction and metabolic disturbances in experimental Swiss Albino rats. After a single dose of gamma-radiation (6 Gy), there was a significant reduction in albumin, total protein and globulin levels and a significant increase in the liver enzymes (ALT, AST, ALP and GGT) and lipid profile parameters (cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol) in gamma-irradiated rats unlike in normal controls. Results: The gamma-irradiated rats pre-treated with J. phoenicea leaf extracts, however, showed a significant increase in albumin, total protein and globulin levels and a significant reduction in liver enzymes and lipid profile parameters as opposed to the untreated ones. The gamma-irradiated rats showed toxic changes in the liver, whereas, the rats pre-treated with J. phoenicea leaves extract demonstrated a protective effect. Additionally, gamma- irradiation caused myocardial degenerative changes, interstitial edema between muscle fibers, necrosis and inflammatory cells infiltration and fibrotic and cellular damages to the heart, but J. phoenicea leaves extract were found to ameliorate the gamma-irradiation-induced changes in the heart. Conclusion: The results suggested that treatment with J. phoenicea leaves extract is possibly safe and can ameliorate gamma-irradiation-induced oxidative damage and tissue injury in rats. The leavesof J. phoenicea could serve as a potential source of therapeutic antioxidants.]]>Correll, D.S. and M.C. Johnston,1970Pages: 1881Pages: 1881Chatterjee, A. and S. Pakrashi,1994Vol. 3,Pages: 76Pages: 76Chaudhary, S.A.,1999Vol. 1,pp: 55pp: 55Akkol, E.K., A. Guvenc and E. Yesilada,2009Juniperus taxa.]]>125330336El-Sawi, S.A., H.M. Motawae and A.M. Ali,2007Juniperus phoenicea L. grown in Egypt.]]>4417426Harborne, J.B.,1993pp: 460-461pp: 460-461Di Carlo, G., N. Mascolo, A.A. Izzo and F. Capasso,199965337353Aboul-Ela, M., N. El-Shaer and T.A. El-Azim,2005Juniperus phoenicea Part II.]]>11240247Bayazit, V.,200425156163Uphof, J.C.,19682nd Edn.,pp: 290pp: 290Dudareva, N., F. Negre, D.A. Nagegowda and I. Orlova,200625417440Tumen, I., I. Suntar, H. Keles and E.K. Akkol,2012Cupressus and Juniperus species growing in Turkey.]]>2012Ali, S.A., M.Z. Rizk, N.A. Ibrahim, M.S. Abdallah, H.M. Sharara and M.M. Moustafa,2010Juniperus phoenicea and Cupressus sempervirens against CCl4.]]>1123131Hall, E.J. and A.J. Giaccia,20066th Edn.,Pages: 546Pages: 546Giardi, M.T., E. Touloupakis, D. Bertolotto and G. Mascetti,2013141716817192El-Bahr, S.M.,20131111117Spitz, D.R., E.I. Azzam, J.J. Li and D. Gius,200423311322Azzam, E.I., J.P. Jay-Gerin and D. Pain,20123274860NRC.,19967th Edn.,Pages: 140Pages: 140Paget, G.E. and J.M. Barnes,19641964pp: 160-167pp: 160-167Elleston, R.D. and W.T. Caraway,19701970pp: 474-542pp: 474-542McGowan, M.W., J.D. Artiss, D.R. Strandbergh and B. Zak,198329538542Burstein, M., H.R. Scholnick and R. Morfin,197011583595Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Burtis, C.A. and R.A. Edward,19993rd Edn.,Pages: 1917Pages: 1917Doumas, B.T., W.A. Watson and H.G. Biggs,1971318796Sherwin, J.E.,19841984pp: 420-438pp: 420-438Tietz, N.W., A.D. Rinker and L.M. Shaw,198321731748Tietz, N.W.,19953rd Edn.,Pages: 405Pages: 405Bancroft, J.D.,2008Pages: 725Pages: 725Gomez, K.A. and A.A. Gomez,19842nd Edn.,Pages: 704Pages: 704Jagetia, G.C.,2007407481Nada, A.S.,200821499514Ammar, A.A.,200941911920Moussa, H.R., A.A.F. Abdel-Aziz, H.G. Osman and M.A.N. Abd-Allah,2015Spirulina platensis.]]>29097Weiss, J.F. and M.R. Landauer,2003189120Jedidi, I., P. Therond, S. Zarev, C. Cosson and M. Couturier et al.,2003421135611365Ibrahim, N.K.,20139712Mansour, H.H.,201312766777Gaur, A. and A.L. Bhatia,200917279Alqasoumi, S.I., K.E.H. El Tahir, A.M. AlSheikh and M.S. Abdel-Kader,2009Juniperus phoenicea.]]>238188Lata, S., S. Singh, K.N. Tiwari and R. Upadhyay,2014Phyllanthus fraternus against a chemotherapeutic drug cyclophosphamide.]]>17321632173Rizk, M.Z., M.S. Abdallah, H.M. Sharara, S.A. Ali, N.A. Ibrahim and M.M. Moustafa,2007Cupressus sempiverens L. and Juniperus phoenicea against carbon tetrachloride hepatotoxicity in rats.]]>28394Rajesh, M.G. and M.S. Latha,20049199104Ono, Y., E. Hattori, Y. Fukaya, S. Imai and Y. Ohizumi,2006Nelumbo nucifera leaves extract in mice and rats.]]>106238244Keskes, H., K. Mnafgui, K. Hamden, M. Damak, A. El Feki and N. Allouche,2014In vitro anti-diabetic, anti-obesity and antioxidant proprieties of Juniperus phoenicea L. leaves from Tunisia.]]>4S649S655Pradeep, K., S.H. Park and K.C. Ko,2008587273280Khamis, F. and M.H. Roushdy,1991241936El-Missiry, M.A., T.A. Fayed, M.R. El-Sawy and A.A. El-Sayed,200766278286Banerjee, S., H. Singh and T.K. Chatterjee,2013Juniperus communis (L.) in streptozotocinnicotinamide induced diabetic rats.]]>41017Mansour, H.H. and S.M. Abu El-Nour,20092299128Soliman, S.M.,2007524656Gaur, V., A. Aggarwal and A. Kumar,201149609618Abdelhalim, M.A.K. and S.A.A. Moussa,20137785792