Pakistan Journal of Biological Sciences1028-88801812-5735Asian Network for Scientific Information10.3923/pjbs.2021.139.145Rhodomyrtus tomentosa) in Preeclamptic Rats]]>IlyasSyafruddin C. SitumorangPutri 12021241Background and Objective: Haramonting (Rhodomyrtus tomentosa) is an alternative herb to improve health because it has many biological activities and antioxidant. HSP-70 levels as biomarkers of preeclampsia affected the anti-apoptosis of damaged cells in the placenta. This study aimed to evaluate the role of HSP-70 expressions by investigating whether effect haramonting leaves in PE rats. Materials and Methods: The study design was control (C): pregnant rats without treatment, PE: Preeclamptic rats, PE+E: PE rats were given 1 mL EVOO kg1 b.wt./day orally (pregnancy 13-19), PE+H: PE rats were given nano herbal haramonting 100 mg kg1 b.wt. (pregnancy 13-19 days). PE+E+H: PE rats were given EVOO 0.5 mL kg1 b.wt. and nano herbal haramonting 50 mg kg1 b.wt. (pregnancy 13-19 day). Surgery was performed by taking blood from the heart for the SGOT/SGPT parameters, creatinine and HSP70. Results: A significant difference was observed in all groups with the value p<0.0001 and HSP-70 Expressions affect in preeclamptic rats after given this herbal. The value of SGOT, SGPT and creatinine can affect preeclamptic rats and can be as a biomarker of preeclampsia. A significant difference also in fetus weight (p<0.01) but an insignificant difference in placental weight (p>0.05). Conclusion: These findings indicate that Nano herbal haramonting and EVOO possess antioxidative effects and a promising drug for the future in the treatment of preeclampsia.]]>Eggers, D.K., W.J. Welch and W.J. Hansen,1997815591573Hunter-Lavin, C., E.L. Davies, M.M. Bacelar, M.J. Marshall, S.M. Andrew and J.H.Williams, 2004324511517Molvarec, A., L. Tamasi, G. Losonczy, K. Madach, Z. Prohaszka and J.J.R. Rigo, 201015237247Situmorang, P.C., S. Ilyas and S. Hutahaean,2019Zanthoxylum acanthopodium) and Extra Virgin Olive Oil (EVOO) effects in the expression of Malondialdehyde (MDA), Heat Shock Protein-70 (HSP70) and placental histology of preeclamptic rats.]]>25205220Molvarec, A., A. Szarka, S. Walentin, G. Bekő, I. Karádi, Z. Prohászka and J. Rigó,201141219571962Vo, T.S. and D.H. Ngo,2019Rhodomyrtus tomentosa as potential functional food.]]>2019Na-Phatthalung, P., M. Teles, S.P. Voravuthikunchai, L. Tort and C. Fierro-Castro,2018Rhodomyrtus tomentosa leaf extract and its derivative compound, rhodomyrtone, on head kidney macrophages of rainbow trout (Oncorhynchus mykiss).]]>44543555Lavanya, G., S.P. Voravuthikunchai and N.H. Towatana,2012Rhodomyrtus tomentosa: A potent natural antioxidant.]]>2012Ilyas, S., S. Hutahaean and D.E. Irianti,20182018Roland-Zejly, L., V. Moisan, I. St-Pierre and J.F. Bilodeau,201132161167Padmini, E., S. Lavanya and V. Uthra,20094710731080Barut, F., A. Barut, B.D. Gun, N.O. Kandemir and E. Aktunc et al.,2010206651656Liu, Y., N. Li, L. You, X. Liu, H. Li and X. Wang, 200814561566Servili, M., B. Sordini, S. Esposto, S. Urbani and G. Veneziani et al.,20143123Elgebaly, H.A., N.M. Mosa, M. Allach, K.F. El-Massry, A.H. El-Ghorab, A.M. Al Hroob and A.M. Mahmoud,201898446453Cárdeno, A., M.K. Magnusson, H. Strid, C.A. de La Lastra, M. Sánchez-Hidalgo and L. Öhman,2014161353360Situmorang, P.C., S. Ilyas, S. Hutahaean, Rosidah and R.D. Manurung,2020Zanthoxylum acanthopodium). ]]>13780788Ilyas, S., F. Murdela, S. Hutahaean and P.C. Situmorang,2019Rhodomyrtus tomentosa (Aiton) Hassk.) on the number of leukocyte type and histology of mice pulmo (Mus musculus L.) exposed to electronic cigarette.]]>717501756Situmorang, P.C. and S. Ilyas,2019Mus musculus after giving nano herbal Rhodomyrtus tomentosa (Haramounting).]]>12633Situmorang, P.C., S. Ilyas and S. Hutahaean,2019Zanthoxylum acanthopodium DC.) and Extra Virgin Olive Oil (EVOO) to kidney histology of preeclampsia rats.]]>2019Situmorang, P.C., S. Ilyas, S. Hutahaean and R. Rosidah,2019Zanthoxylum acanthopodium) and extra virgin olive oil combination on preeclamptic rats liver histology.]]>722262231Nurkhasanah, N., M.S. Bachri and N.R. Azis,2016Hibiscus sabdariffa L.) on sgpt sgot and alpine rates.]]>139096Gao, Y., X. Chen, W. Gao, Y. Yang, H. Ma and X. Ren,20122819771983Teixeira, R.L.D.F., R.G. Morato, P.H. Cabello, L.M.K. Muniz and A.D.S.R. Moreira et al.,2011106716724Chatuphonprasert, W. and K. Jarukamjorn,2012329941001Wu, G.,202052329360Sakthirajan, R., J. Dhanapriya, A. Varghese, K. Saravanakumar and T. Dineshkumar et al.,201811348352Irianti, E., S. ilyas, Rosidah and S. Hutahaean,2018Rattus norvegicus) after giving the EVOO.]]>2018Cicerale, S., L.J. Lucas and R.S.J. Keast,201223129135Wu, P., G. Ma, N. Li, Q. Deng, Y. Yin and R. Huang,2015in vitro and in vivo antioxidant activities of flavonoids rich extract from the berries of Rhodomyrtus tomentosa (Ait.) Hassk.]]>173194202Ekambaran, P., 200148243255Bainbridge, S.A., E.H. Sidle and G.N. Smith, 2005641724