Ange Antoine Abena
Marien Ngouabi University, Brazzaville, Congo
Landry M.Miguel
Marien Ngouabi University, Brazzaville, Congo
Alain Mouanga
Department of Medicine, Marien Ngouabi University, Brazzaville, Congo
Jean M. Ouamba
Faculty of Science, Marien Ngouabi University, Brazzaville, Congo
DorotheeF. Sianard
Marien Ngouabi University, Brazzaville, Congo
Marie H. Thiebolt
Laboratory of Pharmacology, Faculty of Medicine, France
Theophile C. Hondi-assah
Marien Ngouabi University, Brazzaville, Congo
Martin Diatewa
Marien Ngouabi University, Brazzaville, Congo
ABSTRACT
Neuropsychopharmacological effects of aqueous extracts of leaves and seeds of Datura fastuosa (D. fastuosa), a solanaceae recently introduced in Congo as ornamental plant, were studied in rat and mice by oral administration using classical methods. Results revealed that extracts of D. fastuosa were well tolerated by rats. No mortality was observed until 3200 mg kg-1. The doses of 400 and 800 mg kg-1 of leaves and seeds extracts increased motor activity, reduced slightly the duration of barbituric sleeping, antagonized catalepsy and ptosis induced by haloperidol and the immobility induced by forced swimming. D. fastuosa exhibited analgesic effect in acetic acid test with tolerance phenomenon in the leaves but not in the seeds extracts. Only the leaves extract reduced rectal temperature, apomorphin hypothermia and increased water drinking.Those results showed that, at the low doses, D. fastuosa has some antidepressant profile.
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How to cite this article
Ange Antoine Abena, Landry M.Miguel, Alain Mouanga, Jean M. Ouamba, DorotheeF. Sianard, Marie H. Thiebolt, Theophile C. Hondi-assah and Martin Diatewa, 2004. Neuropsychopharmacological Effects of Leaves and Seeds Extracts of Datura fastuosa
. Biotechnology, 3: 109-113.
DOI: 10.3923/biotech.2004.109.113
URL: https://scialert.net/abstract/?doi=biotech.2004.109.113
DOI: 10.3923/biotech.2004.109.113
URL: https://scialert.net/abstract/?doi=biotech.2004.109.113
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