Mohammad Sharifzadeh
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Iran
Kurdistan Sharifzadeh
Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Iran
Mahnaz Khanavi
Department of Pharmacognosy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
Abbas Hadjiakhoondi
Department of Pharmacognosy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
Abbas Shafiee
Department of Medicinal Chemistry, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
ABSTRACT
The aim of this study was to evaluate the anti-inflammatory activities of total methanolic extracts isolated from aerial parts of Stachys persica and Stachys setifera. The anti-inflammatory properties of the extracts were assessed by using two well-characterized inflammatory models, carrageenan-induced paw edema and formalin test in rats and mice. Intraperitoneal injections of the extracts 60 min before carrageenan injection caused significant inhibition on carrageenan-induced paw edema over the dose range 50-200 mg kg-1. The extract of Stachys persica showed more inhibitory effect especially with higher doses (100 and 200 mg kg-1). In the formalin test, intraperitoneal injections of different doses (50, 100 and 200 mg kg-1) of either Stachys persica or Stachys setifera 30 min before formalin injection did not show any inhibitory effects in the first phase (0-10 min) of the formalin-induced pain, but all three doses of the extracts revealed a significant (p<0.01) blockade of the second phase (20-30 min) nociception. The anti-inflammatory properties of both extracts were comparable with indomethacin as a potent non-steroidal anti-inflammatory drug. In conclusion, the present findings provide further evidences for inhibitory effects of Stachys persica and Stachys setifera in inflammatory processes via possible interactions with cyclooxygenase products.
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How to cite this article
Mohammad Sharifzadeh, Kurdistan Sharifzadeh, Mahnaz Khanavi, Abbas Hadjiakhoondi and Abbas Shafiee, 2005. Anti-inflammatory Activities of Methanolic Extracts of Stachys persica
and Stachys setifera on Rats and Mice. International Journal of Pharmacology, 1: 132-137.
DOI: 10.3923/ijp.2005.132.137
URL: https://scialert.net/abstract/?doi=ijp.2005.132.137
DOI: 10.3923/ijp.2005.132.137
URL: https://scialert.net/abstract/?doi=ijp.2005.132.137
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