M. N. Somchit
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
M. H.N. Shukriyah
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
A. A. Bustamam
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
A. Zuraini
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
ABSTRACT
The objective of the present study was to evaluate the anti-pyretic and analgesic activities of aqueous and ethanol extracts of Zingiber zerumbet rhizomes. The anti-pyretic activity of Zingiber zerumbet (25, 50 and 100 mg kg-1) was studied in Brewer`s yeast-induced pyrexia in rats. The analgesic activity of Zingiber zerumbet (10, 25, 50 and 100 mg kg-1) was studied using acetic acid-induced writhing in mice. Both aqueous and ethanol extracts of Zingiber zerumbet showed significant anti-pyretic activities in Brewer`s yeast-induced pyrexia in rats throughout the observation period of 8 h. The ethanol extract of the rhizomes of Zingiber zerumbet however significantly decreased the writhing movements in mice in acetic acid-induced writhing test. In conclusion, rhizomes Zingiber zerumbet have both analgesic and anti-pyretic activities.
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How to cite this article
M. N. Somchit, M. H.N. Shukriyah, A. A. Bustamam and A. Zuraini, 2005. Anti-pyretic and Analgesic Activity of Zingiber zerumbet. International Journal of Pharmacology, 1: 277-280.
DOI: 10.3923/ijp.2005.277.280
URL: https://scialert.net/abstract/?doi=ijp.2005.277.280
DOI: 10.3923/ijp.2005.277.280
URL: https://scialert.net/abstract/?doi=ijp.2005.277.280
REFERENCES
- Habsah, M., M. Amran, M.M. Mackeen, N.H. Lajis and H. Kikuzaki et al., 2000. Screening of Zingiberaceae extracts for antimicrobial and antioxidant activities. J. Ethnopharmacol., 72: 403-410.
CrossRefPubMedDirect Link - Bordia, A., S.K. Verma and K.C. Srivastava, 1997. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent. Fatty Acids, 56: 379-384.
PubMed - Husen, R., L.P.A. Hawariah and M.M. Nallappan, 2004. Screening for antihyperglycaemic activity in several local herbs of Malaysia. J. Ethnopharmacol., 95: 205-208.
Direct Link - Mascolo, N., R. Jain, S.C. Jain and F. Capasso, 1989. Ethnopharmacologic investigation of ginger (Zingiber officinale). J. Ethnopharmacol., 27: 129-140.
CrossRefPubMedDirect Link - Agarwal, A.K., C.V. Rao, K. Sairam, V.K. Joshi and R.K. Goel, 2000. Effect of Piper longum L. Zingiber officianalis L. and Ferula species on gastric ulceration and secretion in rats. Indian J. Exp. Biol., 38: 994-998.
Direct Link - Jantan, I., I.A.A. Rafi and J. Jalil, 2005. Platelet-Activating Factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine, 12: 88-92.
PubMedDirect Link - Nharet-Somchit, N.M. and M.H. Nur-Shukriah, 2003. Anti-inflammatory property of ethanol and water extracts of Zingiber zerumbet. Indian J. Pharmacol., 35: 181-182.
Direct Link - Dambisya, Y.M. and L.T. Lee, 1995. Effects L-NG-nitro arginine methyl ester (L-NAME), L-NG-monomethyl arginine (L-NMMA) and L-arginine on the antinociceptive effects of morphine in mice. Methods Find Exp. Clin. Pharmacol., 17: 577-582.
Direct Link - Meli, R., E. Antonelli and G. Cirino, 2001. Analgesia and cyclo-oxygenase inhibitors. Dig. Liver Dis., 33: S8-S11.
Direct Link - Perianayagam, J.B., S.K. Sharma, A. Joseph and A.J. Christina, 2004. Evaluation of anti-pyretic and analgesic activity of Emblica officinalis Gaertn. J. Ethnopharmacol., 95: 83-85.
PubMedDirect Link - Buffum, M. and J.C. Buffum, 2000. Nonsteroidal anti-inflammatory drugs in the elderly. Pain Manage. Nurs., 1: 40-50.
Direct Link