Fidelis Aondover Gberindyer
Department of Veterinary Physiology, Pharmacology and Biochemistry, University of Agriculture, Makurdi, Nigeria
Noel Wannang
Department of Pharmacology, University of Jos, Jos, Nigeria
Chinedu Adive Akwuobu
Department of Veterinary Pathology and Microbiology, University of Agriculture, Makurdi, Nigeria
ABSTRACT
A comparative plasma pharmacokinetics/Pharmacodynamic modeling of enrofloxacin following administration of three brands of 10% enrofloxacin was studied in healthy broiler chickens using a randomized and parallel design. Pre-treatment and post-treatment samples were obtained from brachial or right jugular veins after having administered 20 mg/kg b.w of enrofloxacin at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12 and 24 h. Plasma samples were analyzed for enrofloxacin concentration by a simple agar disk diffusion microbiological assay. Selected pharmacokinetics parameters were calculated using a non-compartmental model. There was a significant difference in the plasma concentration-time and pharmacokinetics profiles (p<0.05) of the three brands. But the plasma concentrations of enrofloxacin exceeded the MIC90 for most pathogenic bacterial organisms in poultry in all the groups. The PK/PD integration (Cmax/MIC90) values, 16.67, 15.17 and 10.5 h were obtained in animals administered conflox®-vet, kenflox® and pulmotryl® formulations respectively. This correlates with high efficacy and reduced chances for the development of resistant pathogenic bacterial organisms following oral administration of these brands of enrofloxacin oral formulations in broiler chickens.
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How to cite this article
Fidelis Aondover Gberindyer, Noel Wannang and Chinedu Adive Akwuobu, 2010. Comparative Pharmacokinetics/Pharmacodynamic Modeling on Three Brands of 10% Enrofloxacin Oral Formulations in Broiler Chickens. International Journal of Poultry Science, 9: 273-277.
DOI: 10.3923/ijps.2010.273.277
URL: https://scialert.net/abstract/?doi=ijps.2010.273.277
DOI: 10.3923/ijps.2010.273.277
URL: https://scialert.net/abstract/?doi=ijps.2010.273.277
REFERENCES
- Anadon, A., M.R. Martinez-Larranaga, M.J. Diaz, P. Bringas and M.A. Martinez et al., 1995. Pharmacokinetics and residues of enrofloxacin in chickens. Am. J. Vet. Res., 56: 501-506.
PubMedDirect Link - Zuluaga, A.F., M. Agudelo, C.A. Rodriguez and O. Vesga, 2009. Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics. BMC Clin. Pharmacol., 9: 1-1.
PubMedDirect Link - Craig, W.A., 1993. Pharmacodynamics of antimicrobial gents as a basis for determination of dosage regimens. Eur. J. Clin. Microbiol. Infec. Dis., 12: S6-S8.
CrossRefDirect Link - Dowling, P.M., R.C. Wilson, J.W. Tyler and S.H. Duran, 1995. Pharmacokinetics of ciprofloxacin in ponies. J. Vet. Pharmacol. Ther., 18: 7-12.
CrossRefDirect Link - Abu-Basha, E.A., S.M. Gharaibeh, A.M. Abudabos, A.F. Shunnaq and A.M. Al-Majali, 2008. Pharmacokinetics and bioequivalence of two norfloxacin oral dosage forms (Vapcotril-10%® and Mycomas 10%®) in healthy broiler chickens. Int. J. Poult. Sci., 7: 289-293.
CrossRefDirect Link - Haritova, A., H. Djeneva, L. Lashev, P. Sotirova, B. Gyurov and M. Stefanova, 2004. Pharmacokinetics and PK/PD modeling of enrofloxacin in Meleagris gallopavo and gallus domesticus. Bulg. J. Vet. Med., 7: 139-148.
Direct Link - Kwasi, B., W.D. Black and M.E. Scott, 1999. Pharmacokinetics of enrofloxacin given by oral, intravenous and intramuscular routes in broiler chickens. Can. J. Vet. Res., 63: 193-200.
PubMed - Meinen, J.B., J.T. McClure and E. Rosin, 1995. Pharmacokinetic of enrofloxacin in clinically normal dogs and mice drug pharmacodynamics in neutropenic mice with E. coli and Staphylococcal infections. Am. J. Vet. Res., 56: 1219-1224.
PubMedDirect Link - Mouton, J.W. and P.M. Tulkens, 2005. PK/PD modeling: Clinical implication. Proceeding of the ICAACBISAP PK/PD Workshop, April 2, Belgium, Netherlands, pp: 1-57.
Direct Link - Posyniak, A., J. Zmudzki, J. Niedzielska and B. Biernacki, 2001. Bioequivalence study of two formulations of enrofloxacin following oral administration in chickens. Bul. Vet. Res. Inst. Pulawy, 45: 353-358.
Direct Link - Radandt, K.M., M.C. Randall and M.N. Dudley, 1992. Interactions of fluoroquinolones with other drugs: Mechanisms, variability, clinical significance and management. Clin. Infect. Dis., 14: 272-284.
PubMedDirect Link - Reiko, S., T. Yusuke, K. Mitsuo, A. Naoki and S. Kihachiro, 2006. Pharmacokinetics-Pharmaco-dynamics relationship of arbekacin for treatment of patients infected with methicillin-resistant Staphylococcus aureus. J. Antimicrob. Agent Chemother., 50: 3754-3762.
CrossRefDirect Link - Sanjib, I., C.B. Chandana, M. Pritam and B. Mohan, 2005. Pharmacokinetics studies of enrofloxacin in Yak after intramuscular administration. Ir. J. Pharmacol. Therap., 4: 91-94.
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