T. Srilatha
Department of Poultry Science, College of Veterinary Science, S.V.V.U. University, Rajendranagar, Hyderabad-5000 030, India
V. Ravinder Reddy
Department of Poultry Science, College of Veterinary Science, S.V.V.U. University, Rajendranagar, Hyderabad-5000 030, India
S. Qudratullah
Department of Poultry Science, College of Veterinary Science, S.V.V.U. University, Rajendranagar, Hyderabad-5000 030, India
M. V.L.N. Raju
Project Directorate on Poultry, ICAR, Rajendranagar, Hyderabad, India
ABSTRACT
An experiment was conducted to study the effects of alpha-lipoic acid at graded levels (0, 20, 40, 60, 80 mg/kg), Vit-E (10, 50 mg/kg) and their combination in a 5 x 2 factorial design on performance, anti-oxidation and immune response of broilers. 400 day-old male broilers were divided into 10 treatment groups, each with 8 replications (5 broilers in each) and fed one of the test diets till 6 weeks of age. Supplementation of Lipoic acid in broiler diet at 80 mg/kg gave significantly (p<0.05) higher BWG than control. The humoral immune response to NDV at 28 days age significantly (p<0.05) increased with lipoic acid at 20 and 80 mg/kg plus Vit-E 50 mg/kg. At 42 days age, HI titers were significantly (p<0.05) higher in all diets supplemented with lipoic acid than control. Cell mediated immunity was significantly (p<0.05) higher on diets that contained lipoic acid at 60 and 80 mg/kg than control. Similarly, Vit-E at 50 mg/kg also had significantly (p<0.05) higher CMI than Vit-E at 10 mg/kg. Supplementation of lipoic acid and vitamin E influenced the activities of lipid peroxidase. Inclusion of lipoic acid in all dietary treatment groups increased glutathione peroxidase levels. RBC catalase levels significantly (p<0.05) increased on diets that contained lipoic acid at 60 mg/kg. It is concluded that alpha - lipoic acid at 80 mg/kg and Vitamin E at 50 mg/kg may be supplemented to the broiler diet for improved growth, antioxidant status and better immune responses.
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How to cite this article
T. Srilatha, V. Ravinder Reddy, S. Qudratullah and M. V.L.N. Raju, 2010. Effect of Alpha-lipoic Acid and Vitamin E in Diet on the Performance, Antioxidation and Immune Response in Broiler Chicken. International Journal of Poultry Science, 9: 678-683.
DOI: 10.3923/ijps.2010.678.683
URL: https://scialert.net/abstract/?doi=ijps.2010.678.683
DOI: 10.3923/ijps.2010.678.683
URL: https://scialert.net/abstract/?doi=ijps.2010.678.683
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