R. Riboty
Animal Production Graduate Program, Equinoctial Technological University, Sto. Domingo, Ecuador
F. Chamba
Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA
M. Puyalto
Norel S.A., c/Jesus Aprendiz 19, 28007 Madrid, Spain
J. J. Mallo
Norel S.A., c/Jesus Aprendiz 19, 28007 Madrid, Spain
ABSTRACT
Continuous use of antibiotics has generated the need of looking for new alternatives in order to decrease emergence of resistant bacteria. The aim of this study was to evaluate the effect of partially-protected sodium butyrate (PPSB) and virginiamycin (VM) on nutrient digestibility, metabolizable energy, serum metabolites and performance of broiler chickens. A complete randomized block design was used with 1071 one- day old Cobb 500® chickens. Three treatments were established: without antibiotics (T1), with 20 ppm of VM (T2) and with 700 ppm of PPSB (T3). Three mash diets were made: starter (1-14 days), grower (15-28 days) and finisher (29-42 days). In experiment 1, performance and serum metabolites were assessed in 903 chicks distributed in 3 treatments of 7 replicates. One chick per replicate was bled at 11 and 31 days. In experiment 2, nutrient digestibility and metabolizable energy were determined in 168 chicks allocated in 3 treatments of 8 replicates. All excreta were collected between 10-13 and 30-33 days. Dry matter, crude protein, fat digestibility, true metabolizable energy and true metabolizable energy corrected by nitrogen were higher with PPSB (p<0.01). Compared with control, VM improved dry matter and crude protein digestibility at 11 days as well as fiber at 31 days (p<0.01) but decreased glucose, cholesterol (p<0.01) and triglycerides (p = 0.04) at 31 days. PPSB also increased cholesterol at 11 days (p = 0.04) and lowered uric acid at 31 days (p = 0.02) respect to control and VM, respectively. Body weight gain and feed conversion ratio were significantly better with PPSB than other treatments. These results suggest that PPSB can be used as a growth promoter in broiler chicken diets.
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How to cite this article
R. Riboty, F. Chamba, M. Puyalto and J. J. Mallo, 2016. Effect of Partially-Protected Sodium Butyrate and Virginiamycin on Nutrient Digestibility, Metabolizable Energy, Serum Metabolites and Performance of Broiler Chickens. International Journal of Poultry Science, 15: 304-312.
DOI: 10.3923/ijps.2016.304.312
URL: https://scialert.net/abstract/?doi=ijps.2016.304.312
DOI: 10.3923/ijps.2016.304.312
URL: https://scialert.net/abstract/?doi=ijps.2016.304.312
REFERENCES
- Adil, S., T. Banday, G. Ahmad Bhat, M. Salahuddin, M. Raquib and S. Shanaz, 2011. Response of broiler chicken to dietary supplementation of organic acids. J. Cent. Eur. Agric., 12: 498-508.
Direct Link - Aghazadeh, A.M. and M. TahaYazdi, 2012. Effect of butyric acid supplementation and whole wheat inclusion on the performance and carcass traits of broilers. S. Afr. J. Anim. Sci., 42: 241-248.
Direct Link - Ahmadi, F., 2011. The effect of different levels of virginiamycin on performance, immune organs and blood metabolite of broiler chickens. Ann. Biol. Res., 2: 291-298.
Direct Link - Antongiovanni, M., A. Buccioni, F. Petacchi, S. Leeson, S. Minieri, A. Martini and R. Cecchi, 2007. Butyric acid glycerides in the diet of broiler chickens: Effects on gut histology and carcass composition. Ital. J. Anim. Sci., 6: 19-25.
Direct Link - Antongiovanni, M., A. Buccioni, S. Minieri, I. Galigani and S. Rapaccini, 2010. Monobutyrine: A novel feed additive in the diet of broiler chickens. Ital. J. Anim. Sci., 9: 369-371.
CrossRefDirect Link - Bartov, I., 1987. Combined effect of age and ambient temperature on the comparative growth of broiler chicks fed tallow and soybean oil. Poult. Sci., 66: 273-279.
CrossRefDirect Link - Bartov, I., 1992. Lack of effect of dietary energy‐to‐protein ratio and energy concentration on the response of broiler chickens to virginiamycin. Br. Poult. Sci., 33: 381-391.
CrossRefDirect Link - Baurhoo, B., P.R. Ferket and X. Zhao, 2009. Effects of diets containing different concentrations of mannanoligosaccharide or antibiotics on growth performance, intestinal development, cecal and litter microbial populations and carcass parameters of broilers. Poult. Sci., 88: 2262-2272.
CrossRefDirect Link - Belay, T. and R.G. Teeter, 1996. Virginiamycin and caloric density effects on live performance, blood serum metabolite concentration and carcass composition of broilers reared in thermoneutral and cycling ambient temperatures. Poult. Sci., 75: 1383-1392.
CrossRefPubMedDirect Link - Bowes, V.A., R.J. Julian and T. Stirtzinger, 1989. Comparison of serum biochemical profiles of male broilers with female broilers and White Leghorn chickens. Can. Vet. Res., 53: 7-11.
PubMedDirect Link - Bray, J.L., C.S. Taylor, T.E. Cherry and J. Carey, 2009. Performance comparison between the use and nonuse of an enteric health medication program across five consecutive commercial broiler flocks. J. Applied Poult. Res., 18: 165-171.
CrossRefDirect Link - Brzoska, F., B. Sliwinski and O. Michalik-Rutkowska, 2013. Effect of dietary acidifier on growth, mortality, post-slaughter parameters and meat composition of broiler chickens. Ann. Anim. Sci., 13: 85-96.
Direct Link - Cervantes, H.M., K.W. Bafundo, G.M. Pesti and R.I. Bakalli, 2008. Live and processing performance responses of broilers fed low and extra-low nutrient density withdrawal diets supplemented with virginiamycin. J. Applied Poult. Res., 17: 87-92.
CrossRefDirect Link - Chamba, F., M. Puyalto, A. Ortiz, H. Torrealba, J.J. Mallo and R. Riboty, 2014. Effect of partially protected sodium butyrate on performance, digestive organs, intestinal villi and E. coli development in broilers chickens. Int. J. Poult. Sci., 13: 390-396.
CrossRefDirect Link - Chan, G., A. Guthrie, T. Sivaramalingam, J. Wilson, D. Vancraeynest, R. Moody and S. Clark, 2015. A framework for assessing the efficacy of antimicrobials in the control of necrotic enteritis in broiler chickens. J. Applied Poult. Res., 24: 246-256.
CrossRefDirect Link - Cuhadar, S., A. Atay, M. Koseoglu, A. Dirican and A. Hur, 2012. Stability studies of common biochemical analytes in serum separator tubes with or without gel barrier subjected to various storage conditions. Biochemia Medica, 22: 202-214.
Direct Link - Cuff, M.A., E.W. Lambert and S.R. Shirazi-Beechey, 2002. Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J. Physiol., 539: 361-371.
CrossRefDirect Link - Demir, E., S. Sarica, A. Sekeroglu, M.A. Ozcan and Y. Seker, 2004. Effects of early and late feed restriction or feed withdrawal on growth performance, ascites and blood constituents of broiler chickens. Acta Agriculturae Scandinavica Sect. A: Anim. Sci., 54: 152-158.
CrossRefDirect Link - Dhama, K., R. Tiwari, R.U. Khan, S. Chakraborty and M. Gopi et al., 2014. Growth promoters and novel feed additives improving poultry production and health, bioactive principles and beneficial applications: The trends and advances-a review. Int. J. Pharmacol., 10: 129-159.
CrossRefDirect Link - Dumonceaux, T.J., J.E. Hill, S.M. Hemmingsen and A.G. van Kessel, 2006. Characterization of intestinal microbiota and response to dietary virginiamycin supplementation in the broiler chicken. Applied Environ. Microbiol., 72: 2815-2823.
CrossRefDirect Link - El-Sawy, A.F., Z. El-Maddawy, H.S. Ibrahiem and S. Bo-Ghazel, 2015. The growth promoting effect of β-glucan in comparison with sodium butyrate in broiler chicks. Alexandria J. Vet. Sci., 44: 23-37.
CrossRefDirect Link - Eyssen, H., V. de Prins and P. de Somer, 1962. The growth-promoting action of virginiamycin and its influence on the crop flora in chickens. Poult. Sci., 41: 227-233.
CrossRefDirect Link - Eyssen, H. and P. de Somer, 1963. The mode of action of antibiotics in stimulating growth of chicks. J. Exp. Med., 117: 127-138.
Direct Link - Eyssen, H. and P. de Somer, 1963. Effect of antibiotics on growth and nutrient absorption of chicks. Poult. Sci., 42: 1373-1379.
CrossRefDirect Link - Fernandez-Rubio, C., C. Ordonez, J. Abad-Gonzalez, A. Garcia-Gallego, M.P. Honrubia, J.J. Mallo and R. Balana-Fouce, 2009. Butyric acid-based feed additives help protect broiler chickens from Salmonella Enteritidis infection. Poult. Sci., 88: 943-948.
CrossRefDirect Link - Guilloteau, P., L. Martin, V. Eeckhaut, R. Ducatelle, R. Zabielski and F. Van Immerseel, 2010. From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr. Res. Rev., 23: 366-384.
CrossRefDirect Link - Khan, S.H. and J. Iqbal, 2016. Recent advances in the role of organic acids in poultry nutrition. J. Appl. Anim. Res., 44: 359-369.
CrossRefDirect Link - Harms, R.H., N. Ruiz and R.D. Miles, 1986. Influence of virginiamycin on broilers fed four levels of energy. Poult. Sci., 65: 1984-1986.
CrossRefPubMedDirect Link - Hill, F.W. and D.L. Anderson, 1958. Comparison of metabolizable energy and productive energy determinations with growing chicks. J. Nutr., 64: 587-603.
CrossRefPubMedDirect Link - Hu, Z. and Y. Guo, 2007. Effects of dietary sodium butyrate supplementation on the intestinal morphological structure, absorptive function and gut flora in chickens. Anim. Feed Sci. Technol., 132: 240-249.
CrossRefDirect Link - Huyghebaert, G., R. Ducatelle and F. van Immerseel, 2011. An update on alternatives to antimicrobial growth promoters for broilers. Vet. J., 187: 182-188.
CrossRefDirect Link - Jerzsele, A., K. Szeker, R. Csizinszky, E. Gere, C. Jakab, J.J. Mallo and P. Galfi, 2012. Efficacy of protected sodium butyrate, a protected blend of essential oils, their combination and Bacillus amyloliquefaciens spore suspension against artificially induced necrotic enteritis in broilers. Poult. Sci., 91: 837-843.
CrossRefDirect Link - Kaczmarek, S.A., A. Barri, M. Hejdysz and A. Rutkowski, 2016. Effect of different doses of coated butyric acid on growth performance and energy utilization in broilers. Poult. Sci.
CrossRefDirect Link - Ketels, E. and G. De Groote, 1989. Effect of ratio of unsaturated to saturated fatty acids of the dietary lipid fraction on utilization and metabolizable energy of added fats in young chicks. J. Poult. Sci., 68: 1506-1512.
CrossRefPubMedDirect Link - Kotunia, A., J. Wolinski, D. Laubitz, M. Jurkowska, V. Rome, P. Guilloteau and R. Zabielski, 2004. Effect of sodium butyrate on the small intestine development in neonatal piglets feed by artificial sow. J. Physiol. Pharmacol., 2: 59-68.
PubMedDirect Link - LaVorgna, M., J.L. Schaeffer, D. Bade, J. Dickson, K. Cookson and S.W. Davis, 2013. Performance of broilers fed a broader spectrum antibiotic (virginiamycin) or a narrower spectrum antibiotic (bacitracin methylene disalicylate) over 3 consecutive grow-out cycles. J. Applied Poult. Res., 22: 574-582.
CrossRefDirect Link - Leeson, S., H. Namkung, M. Antongiovanni and E.H. Lee, 2005. Effect of butyric acid on the performance and carcass yield of broiler chickens. Poult. Sci., 84: 1418-1422.
CrossRefDirect Link - Levy, A.W., J.W. Kessler, L. Fuller, S. Williams, G. F. Mathis, B. Lumpkins and F. Valdez, 2015. Effect of feeding an encapsulated source of butyric acid (ButiPEARL) on the performance of male Cobb broilers reared to 42 d of age. Poult. Sci., 94: 1864-1870.
CrossRefDirect Link - Li, J., Y. Hou, D. Yi, J. Zhang and L. Wang et al., 2015. Effects of tributyrin on intestinal energy status, antioxidative capacity and immune response to lipopolysaccharide challenge in broilers. Asian-Australasian Asian Aust. J. Anim. Sci., 28: 1784-1793.
CrossRefDirect Link - Mahdavi, R. and M. Torki, 2009. Study on usage period of dietary protected butyric acid on performance, carcass characteristics, serum metabolite levels and humoral immune response of broiler chickens. J. Anim. Vet. Adv., 8: 1702-1709.
Direct Link - Mallo, J.J., M. Puyalto and S.V.R. Rao, 2011. Evaluation of the effect of sodium butyrate addtition to broiler diets on energy and protein digestibility, productive parameters and size of intestinal villi of animals. Proceedings of the 48th AECA Scientific Poultry Symposium, November 4, 2011, Australia, pp: 343-349.
- Mallo, J.J., A. Balfagon, M.I. Gracia, P. Honrubia and M. Puyalto, 2012. Evaluation of different protections of butyric acid aiming for release in the last part of the gastrointestinal tract of piglets. J. Anim. Sci., 90: 227-229.
CrossRefDirect Link - Marjani, A., 2006. Effect of storage time and temperature on some serum analytes. Internet J. Lab. Med., Vol. 2, No. 2.
Direct Link - March, B.E., R. Soong and C. MacMillan, 1978. Growth rate, feed conversion and dietary metabolizable energy in response to virginiamycin supplementation of different diets. Poult. Sci., 57: 1346-1350.
CrossRefDirect Link - Meluzzi, A., G. Primiceri, R. Giordani and G. Fabris, 1992. Determination of blood constituents reference values in broilers. Poult. Sci., 71: 337-345.
CrossRefPubMedDirect Link - Mohan, B., R. Kadirvel, M. Bhaskaran and A. Natarajan, 1995. Effect of probiotic supplementation on serum/yolk cholesterol and on egg shell thickness in layers. Br. Poult. Sci., 36: 799-803.
CrossRefDirect Link - Mohan, B., R. Kadirvel, A. Natarajan and M. Bhaskaran, 1996. Effect of probiotic supplementation on growth, nitrogen utilisation and serum cholesterol in broilers. Br. Poult. Sci., 37: 395-401.
CrossRefPubMedDirect Link - Moquet, P.C.A., L. Onrust, F. van Immerseel, R. Ducatelle, W.H. Hendriks and R.P. Kwakkel, 2016. Importance of release location on the mode of action of butyrate derivatives in the avian gastrointestinal tract. World's Poult. Sci. J., 72: 61-80.
CrossRefDirect Link - Ni, J.J., T.T. Ju and X.S. Piao, 2012. Effect of flavomycin on performance, gut morphology and intestinal microflora in broilers. J. Anim. Vet. Adv., 11: 1669-1673.
Direct Link - Oddoze, C., E. Lombard and H. Portugal, 2012. Stability study of 81 analytes in human whole blood, in serum and in plasma. Clin. Biochem., 45: 464-469.
CrossRefDirect Link - Odunsi, A.A., A.A. Onifade and G.M. Babatunde, 1999. Response of broiler chicks to virginiamycin and dietary protein concentrations in the humid tropics. Archivos Zootecnia, 48: 317-325.
Direct Link - Panda, A.K., S.V.R. Rao, M.V.L.N. Raju and G.S. Sunder, 2009. Effect of butyric acid on performance, gastrointestinal tract health and carcass characteristics in broiler chickens. Asian-Australasian J. Anim. Sci., 22: 1026-1031.
CrossRefDirect Link - Parks, C.W., J.L. Grimes, P.R. Ferket and A.S. Fairchild, 2001. The effect of mannanoligosaccharides, bambermycins and virginiamycin on performance of large white male market turkeys. Poult. Sci., 80: 718-723.
CrossRefDirect Link - Piotrowska, A., K. Burlikowska and R. Szymeczko, 2011. Changes in blood chemistry in broiler chickens during the fattening period. Folia Biologica, 59: 183-187.
CrossRefPubMedDirect Link - Proudfoot, F.G., E.D. Jackson and H.W. Hulan, 1990. The response of male chicken broilers to the dietary addition of virginiamycin. Poult. Sci., 69: 1713-1717.
CrossRefDirect Link - Rajman, M., M. Jurani, D. Lamosova, M. Maeajova and M. Sedlaekova et al., 2006. The effects of feed restriction on plasma biochemistry in growing meat type chickens (Gallus gallus). Comp. Biochem. Physiol. Part A: Mol. Integr. Physiol., 145: 363-371.
CrossRefDirect Link - Rinttila, T. and J. Apajalahti, 2013. Intestinal microbiota and metabolites-implications for broiler chicken health and performance. J. Applied Poult. Res., 22: 647-658.
CrossRefDirect Link - Shahir, M.H., S. Moradi, O. Afsarian and O. Esmaeilipour, 2013. Effects of cereal type, enzyme and sodium butyrate addition on growth performance, carcass traits and intestinal morphology of broilers. Revista Brasileira Ciencia Avicola, 15: 181-189.
CrossRefDirect Link - Sibbald, I.R., 1976. A bioassay for true metabolizable energy in feedingstuffs. Poult. Sci., 55: 303-308.
CrossRefDirect Link - Singh, M., R.K. Srivastava, S.S. Chauhan and K.S. Singh, 2000. Responses of virginiamycin and bacitracin methylene disalicylate on the weight gains and nutrient utilization of broiler chicken. Indian J. Poult. Sci., 35: 272-275.
Direct Link - Smulikowska, S., J. Czerwinski, A. Mieczkowska and J. Jankowiak, 2009. The effect of fat-coated organic acid salts and a feed enzyme on growth performance, nutrient utilization, microflora activity and morphology of the small intestine in broiler chickens. J. Anim. Feed Sci., 18: 478-489.
Direct Link - Taherpour, K., H. Moravej, M. Shivazad, M Adibmoradi and B. Yakhchali, 2009. Effects of dietary probiotic, prebiotic and butyric acid glycerides on performance and serum composition in broiler chickens. Afr. J. Biotechnol., 8: 2329-2334.
Direct Link - Vervaeke, I.J., J.A. Decuypere, N.A. Dierick and H.K. Henderickx, 1979. Quantitative in vitro evaluation of the energy metabolism influenced by virginiamycin and spiramycin used as growth promoters in pig nutrition. J. Anim. Sci., 49: 846-856.
Direct Link - Abd El-Ghany, W.A., M.H. Awaad, S.A. Nasef and A.F. Gaber, 2016. Effect of sodium butyrate on Salmonella enteritidis infection in broiler chickens. Asian J. Poult. Sci., 10: 104-110.
CrossRefDirect Link - Yang, Z., Y. Zaibin and Y. Weiren, 2010. Effects of different levels of sodium butyrate on nutrient utilization of broilers. China Feed, 8: 7-7.
Direct Link - Zhang, W.H., Y. Jiang, Q.F. Zhu, F. Gao, S.F. Dai, J. Chen and G.H. Zhou, 2011. Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens. Br. Poult. Sci., 52: 292-301.
CrossRefDirect Link - Zhang, W.H., F. Gao, Q.F. Zhu, C. Li, Y. Jiang, S.F. Dai and G.H. Zhou, 2011. Dietary sodium butyrate alleviates the oxidative stress induced by corticosterone exposure and improves meat quality in broiler chickens. Poult. Sci., 90: 2592-2599.
CrossRefDirect Link