Sha Zhu
Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, PR China
Guangming Gong
Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, PR China
Judith Apondi Oremo
Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, PR China
Minghui Zhen
Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, PR China
Tao Huang
Department of Hepatobiliary Surgery, Henan Provincial Cancer Hospital, Zhengzhou, Henan 450008, P.R. China
Yue Tang
Department of Microbiology and Immunology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, PR China
Guoqing Feng
Center of Functional Experiment, Basic Medical College of Zhengzhou University, Zhengzhou 450001, P.R. China
ABSTRACT
Analyzing Differential Expression Gene (DEG) and identifying candidate gene in prostate cancer cell lines that were resistant to docetaxel, which might be used for the purposes of screening targeted therapy. Gene expression pro?les of the tumors from docetaxel treated mice were performed using Agilent human whole genomic oligonucleotide microarrays. The microarray data were validated and the differential expression genes were analyzed using IPA software. The prostate cancer cell lines PC3 and LNCaP were sensitive to docetaxel but VcaP and CWR22 were resistant to docetaxel cell lines. It indicated that some genes up-regulated or down-regulated in docetaxel resistant cell lines may be candidate genes for targeted therapy, after evaluating by Gene Expression Microarray and signal pathway. The significantly up-regulated genes including Bcl-11A, EPHA4 and CX3CL1 may be the potential candidates for further investigation in docetaxel-resistant tumor cells.
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How to cite this article
Sha Zhu, Guangming Gong, Judith Apondi Oremo, Minghui Zhen, Tao Huang, Yue Tang and Guoqing Feng, 2013. Microarray and Pathway Analysis of Differential Gene Expression Between Two Kinds of Prostate Cancer Cell Lines Sensitive and Insensitive to Docetaxel. Information Technology Journal, 12: 8281-8286.
DOI: 10.3923/itj.2013.8281.8286
URL: https://scialert.net/abstract/?doi=itj.2013.8281.8286
DOI: 10.3923/itj.2013.8281.8286
URL: https://scialert.net/abstract/?doi=itj.2013.8281.8286
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