N. A. Meguid
Department of Research on Children with Special Needs, National Research Centre, Cairo, Egypt
E. Ashour
Department of Biochemistry, National Research Centre, Cairo, Egypt
A. A. Dardir
Department of Research on Children with Special Needs, National Research Centre, Cairo, Egypt
ABSTRACT
The present study was carried out on 51 individuals with Down syndrome (DS); 39 patients with trisomy 21 and 12 patients with mosaicism as well as their 22 matched controls. Their ages ranged from 2 months to 18 years. The purpose of this work was to study the level and the gene dosage effect of serum endostatin in DS children and control subjects. Present results showed significant high levels of endostatin in the population with complete trisomy 21 compared to mosaicism and control subjects, whereas, in cases with mosaicism, endostatin levels showed no statistical difference compared to control subjects. Congenital heart disease was present in 58.8%. No significant difference in endostatin levels between cases with congenital heart and cases without. Reviewing the literature showed that DS patients are resistant to solid tumours and rarely have haemangiomas. This study concluded that the increased levels of endostatin is a gene dosage effect (three copies of the protein) and it could be used as a preventive protein for high risk population up to the level seen in DS without side effects. The present work is important in the field of angiogenesis, not only from research area, but also from product development safety.
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How to cite this article
N. A. Meguid, E. Ashour and A. A. Dardir, 2004. High Serum Endostatin Level in Egyptian Children with Down Syndrome: Gene Dosage Effect. Journal of Biological Sciences, 4: 386-390.
DOI: 10.3923/jbs.2004.386.390
URL: https://scialert.net/abstract/?doi=jbs.2004.386.390
DOI: 10.3923/jbs.2004.386.390
URL: https://scialert.net/abstract/?doi=jbs.2004.386.390
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