Berna Guney Saruhan
Department of Histology and Embryology, Faculty of Veterinary Medicine, University ofDicle, Diyarbakir, Turkey
M. Aydin Ketani
Department of Histology and Embryology, Faculty of Veterinary Medicine, University ofDicle, Diyarbakir, Turkey
Yusuf Nergiz
Departments of Histology and Embryology, Faculty of Medical, University ofDicle, Diyarbalar, Turkey
Celal Ilgaz
Departments of Histology and Embryology, Faculty of Medical, University ofGazi, Ankara, Turkey
Murat Akkus
Departments of Biology, Faculty of Education, University of Dicle, Diyarbakir, Turkey
Sennur Ketani
Departments of Biology, Faculty of Education, University of Dicle, Diyarbakir, Turkey
ABSTRACT
In this study, we aimed to investigate Clomiphene Citrate (CC) on vagen of adult Ovariectomised rats. Transmission electron microscopy and light microscopy have been used to study changes to the vaginal epithelium induced by C administered to Ovariectomised rats. The study was performed in Department of Medical Science Application and Research Centre of Dicle University, DUSAM-Turkey in 2001. Ten female, Wistar Albino rats were used and were divided into three groups. At the beginning and end of the administrations, body weight of animals was determined. Animals were sacrificed 35 days after ovariectomised and vaginal tissue was examined by transmission electron microscopy and light microscopy. We found that, the body weight was higher in the ovariectomized rats than the control rats. Further, body weight increased after clomiphene citrate therapy. It was found that clomiphene citrate treatment produced ultra structural surface features some of which were similar to those seen with hormone treatments and others unique to clomiphene alone. In conclusion, antiestrogen clomiphene citrate administration affects vagina epithelium and lead to increasing body weight.
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How to cite this article
Berna Guney Saruhan, M. Aydin Ketani, Yusuf Nergiz, Celal Ilgaz, Murat Akkus and Sennur Ketani, 2008. The Effects of Clomiphene Citrate Administration in Ovariectomised Rats: An Ultrastructural Study. Journal of Biological Sciences, 8: 60-66.
DOI: 10.3923/jbs.2008.60.66
URL: https://scialert.net/abstract/?doi=jbs.2008.60.66
DOI: 10.3923/jbs.2008.60.66
URL: https://scialert.net/abstract/?doi=jbs.2008.60.66
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