Ahmed Rashad M.Abu Ghadeer
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Samia E.Ali
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Soheir A.A. Osman
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ABSTRACT
Adriamycin (ADR) is one of the most potent antineoplastic agents known, however, its clinical use is limited due to its cardiotoxicity. In this investigation, the role of silymarin (flavonoid found in most plants) against the action of ADR and radiation was evaluated. ADR was injected to rats in four equal doses (3 mg/kg body weight twice a week) and after the last dose rats were exposed to whole body (6 Gy) gamma irradiation. Blood samples were taken 1 and 10 days after radiation exposure. Silymarin was orally administered 10 days before ADR injection. ADR and radiation have dramatic effects on the blood level of lactate dehydrogenase (LDH), creatinine phosphokinase (CPK), indicating heart toxicity, as well as on the content of malondialdehyde (MDA) & glutathione (GSH) and the activity level of gluathione peroxidase (GSH-Px) & superoxide dismutase (SOD), indicating depression in the antioxidant system. The effect was more deleterious on the 10th day than the 1st day of investigation (indicating late and continuos action of ADR and radiation). Production of free radicals of both ADR and radiation may be the main cause of the altered biochemical levels of the assayed parameters. Daily intubation of silymarin reduced the alterations in the assayed biochemical parameters induced by ADR and/or radiation in rats.
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How to cite this article
Ahmed Rashad M.Abu Ghadeer, Samia E.Ali and Soheir A.A. Osman, 2001. Antagonistic Role of Silymarin Against Cardiotoxicity and Impaired Antioxidation Induced
by Adriamycin and/or Radiation Exposure in Albino Rats . Pakistan Journal of Biological Sciences, 4: 604-607.
DOI: 10.3923/pjbs.2001.604.607
URL: https://scialert.net/abstract/?doi=pjbs.2001.604.607
DOI: 10.3923/pjbs.2001.604.607
URL: https://scialert.net/abstract/?doi=pjbs.2001.604.607
REFERENCES
- Abdel-Aleem, S., M.M. El-Merzabani, M. Sayed-Ahmed, D.A. Taylor and J.E. Lowe, 1997. Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. J. Mol. Cell. Cardiol., 29: 789-797.
CrossRefDirect Link - Ames, B.N., L.S. Gold and W.C. Willet, 1995. The causes and prevention of cancer. Proc. Natl. Acad. Sci. USA., 92: 5258-5265.
PubMedDirect Link - Behnia,K. and M. Boroujerdi, 1999. Inhibition of aldo-keto reductases by phenobarbital alters metabolism pharmacokinetics and toxicity of doxorubicin in rats. J. Pharm. Pharmacol., 51: 1275-1282.
Direct Link - Bohles, H., T. Noppeney, Z. Akcetin, J. Rein and J.V. Embey, 1986. The effect of preoperative L-carnitine supplementation on myocardial metabolism during aorto-coronary bypass surgery. Curr. Theret. Res., 39: 429-435.
Direct Link - Booser, D.J. and G.N. Hortobagyi, 1994. Anthracycline antibiotics in cancer therapy focus on drug resistance. Drugs, 47: 223-258.
PubMed - Corr, P.B., R.S. Gross and B.E. Sobel, 1985. Amphipathic metabolites and membrane dysfunction in ischemic myocardium. Circ. Res., 55: 135-154.
Direct Link - Kimura, T., I. Fujita, N. Itoh, N. Muto and T. Nakanishit et al., 2000. Metallothionein acts as a cytoprotectant against doxorubicin toxicity. J. Pharmacol. Exp. Ther., 292: 299-302.
Direct Link - Masayasu, M. and Y. Hiroshi, 1979. A simplified assay method of superoxide dismutase activity for clinical use. Clin. Chim. Acta, 92: 337-342.
CrossRefPubMedDirect Link - Paglia, D.E. and W.N. Valentine, 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med., 70: 158-169.
CrossRefPubMedDirect Link - Van Acker, S.A.B.E., D.J. van den Berg, M.N.J.L. Tromp, D.H. Grifioen, W.P. van Bennekom, W.J.F. van der Vijgh and A. Bast, 1996. Structural aspects of antioxidant activity of flavonoids. Free Radic. Biol. Med., 20: 331-342.
CrossRefPubMedDirect Link - Yoshioka, T., K. Kawada, T. Shimada and M. Mori, 1979. Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood. Am. J. Obstet. Gynecol., 135: 372-376.
CrossRefPubMedDirect Link