A. M. Awadallah
Not Available
F. I. Moussa
Not Available
N. Abad El Hameed
Not Available
ABSTRACT
The effect of cisplatin (8 mg/kg b.wt. i.p) on the haemopoietic system alone or in combination with lasix (0.25 mg/kg b. wt, i.m) or sodium selenite (20 μ mol/kg b. wt. i.m) or both were discussed in the male albino rabbits for 6 weeks. The IP injection of cisplatin induced a marked decreases in body weight, in the number of red blood cells; haemoglobin contents; haematocrit values and iron levels in the plasma, accompained by an elevations in total bilirubin. Co-administration of lasix with cisplatin partially improved the loss of body weight and the treatment of haematological parameters. Co-administration of selenium with cisplatin partially improved the loss of body weight and completely improved the haematological parameters. Treatment of cisplatin with lasix or sodium selenite or both completely prevented haematological toxicity of cisplatin and the animals restored their normal weight.
PDF References Citation
How to cite this article
A. M. Awadallah, F. I. Moussa and N. Abad El Hameed, 2001. Treatment of Cisplatin Haematotoxicity with Lasix or Selenium or Both in Adult Male Rabbits. Pakistan Journal of Biological Sciences, 4: 89-93.
DOI: 10.3923/pjbs.2001.89.93
URL: https://scialert.net/abstract/?doi=pjbs.2001.89.93
DOI: 10.3923/pjbs.2001.89.93
URL: https://scialert.net/abstract/?doi=pjbs.2001.89.93
REFERENCES
- Araya, Y., H. Miyamoto, T. Kondo, H. Isobe and T. Shimizu et al., 1990. Studies on the mechanism of protective effect of selenium on nephrotoxicity of cis-diamminedichloroplatinum (CDDP) in mice. Cancer Chemother., 17: 2083-2089.
PubMedDirect Link - Eaton, D.L., N.H. Stacey, K.L. Wong and C.D. Klaassen, 1980. Dose-response effects of various metal ions on rat liver metallothionein glutathione heme oxygenase and cytochrome P-450. Toxicol. Applied Pharmacol., 55: 393-402.
CrossRef - Lechner, W., E.A. Dworzak, E. Solder, M. Sachsenmaier, D. Kolle, H. Moncayo and R. Reitsamer, 1992. Influence on erythropoietin levels of treatment with cisplatinum-endoxan. J. Arch. Gynecol. Obstetrics, 252: 49-53.
CrossRef - Working, P.K., M.S. Newman, T. Sullivan, M. Brunner, M. Podell, Z. Sahenk and N. Turner, 1998. Comparative intravenous toxicity of cisplatin solution and cisplatin encapsulated in long-circulating, pegylated liposomes in cynomolgus Monkeys. Med. Toxicol. Sciences, 46: 155-165.
Direct Link - Rosenberg, B., L. Van Camp, J.E. Trosko, V.H. Mansour, 1969. Platinum compounds: A new class of potent antitumour agents. Nature, 22: 385-386.
CrossRef - Schaeppi, U., I.A. Heyman, R.W. Fleischman, H. Rosenkrantz and V. Ilievski et al., 1973. cis-Dichlorodiammineplatinum(II) (NSC-119 875): Preclinical toxicologic evaluation of intravenous injection in dogs, monkeys and mice. Toxicol. Applied Pharmacol., 25: 230-241.
CrossRefDirect Link - Wallenstein, S., C.L. Zucker and J.J. Fleiss, 1980. Some statistical methods useful in circulation research. Circ. Res., 47: 1-9.
CrossRefDirect Link