Abbas Hajifathali
Not Available
Bahram Kazemi
Not Available
Aliakbar Pourfathollah
Not Available
Ghasem Rastegar Lari
Not Available
Rouzbeh Chegeni
Not Available
ABSTRACT
Human coagulation factor V serves as a cofactor for factor X in thrombin formation. Generation of thrombin leads to fibrin and clot formation. In this study 65 patients were selected with venous thrombosis. Patients with a positive Protein C resistance were chosen and screened genetically by Conformation Sensitive Gel Electrophoresis (CSGE) for the presence of factor V mutations, the suspected mutations were sequenced. Three new mutations were found as follows, Met 385 thr, Met 1736 Val and Lys 386 Lys. Present study shows factor V mutations leading to thrombosis that have been never reported in Iran
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How to cite this article
Abbas Hajifathali, Bahram Kazemi, Aliakbar Pourfathollah, Ghasem Rastegar Lari and Rouzbeh Chegeni, 2005. Coagulation Factor V Mutations in Iranian Patients with Venous Thrombosis. Pakistan Journal of Biological Sciences, 8: 1272-1274.
DOI: 10.3923/pjbs.2005.1272.1274
URL: https://scialert.net/abstract/?doi=pjbs.2005.1272.1274
DOI: 10.3923/pjbs.2005.1272.1274
URL: https://scialert.net/abstract/?doi=pjbs.2005.1272.1274
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