I. M. Wiam
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Maiduguri, Nigeria
T. W. Jacks
Department of Human Anatomy, College of Medical Sciences, University of Maiduguri, Nigeria
Y. A. Zongoma
Department of Veterinary Physiology/Pharmacology, Faculty of Veterinary Medicine,
University of Maiduguri, Nigeria
ABSTRACT
The toxicological effects of the ethanol extract of Cassia siamea were investigated in rats. Acute toxicity study was conducted following intraperitoneal administration of graded doses of the plant extract. LD50 of Cassia siamea extract was found to be 9600 mg kg-1 body weight. Mortality occurred in rats treated with high doses of 4000, 5000, 6000, 7000, 8000 and 16000 mg kg-1 and appears to be dose dependent. Phytochemical analysis of ethanol extract of Cassia siamea leaf indicated that it contained alkaloids, glycosides, anthraquinones, steroids, tannins and saponins.
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How to cite this article
I. M. Wiam, T. W. Jacks and Y. A. Zongoma, 2005. Acute Toxicity and Phytochemical Studies of Cassia siamea Extract in Rats. Pakistan Journal of Biological Sciences, 8: 586-588.
DOI: 10.3923/pjbs.2005.586.588
URL: https://scialert.net/abstract/?doi=pjbs.2005.586.588
DOI: 10.3923/pjbs.2005.586.588
URL: https://scialert.net/abstract/?doi=pjbs.2005.586.588
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