Research Article
Interpretation of Fission Product Effects on Human Body
Department of Applied Physics, Tafila Technical University, Tafila, Jordan
Amin Al-Okour
Department of Applied Sciences, Husun College, Balqa University, Husun, Jordan
The physical and chemical form of radionuclides may vary depending on the release and transport conditions in addition to the properties of the element. A general distinction can be made between gases, aerosols and particulate material (Choppin et al., 2002).
Fission Products (FP) behavior has been studied for a long time via comprehensive analyses that resulted in a number of models developed to express and explain this behavior. According these models, large numbers of fatalities, malignancies, thyroid cancer, genic defects were predicted; nevertheless, the facts after Chernobyl and TMI accidents and nuclear detonations in USA and Marshal Islands, were not consistent with what was predicted. The DAB hypothesis (Ajlouni, 2006) is a new approach introduced to explain FP behaviors inside the reactor and in the environment.
According to IAEA report on Chernobyl accident (Anonymous, 1996, 2006), no sustained severe impacts on populations or ecosystem have been observed and a low risk was associated with the present radiation levels in most of the contaminated areas.
Of the 7.1 Million residents of contaminated territories, many predictive models estimated 470 fatalities, due to leukemia in ten years. But to the year 1996, no consistent attributable increase has been detected either in the rate of leukemia or in the incidence of any malignancies in regions in which the levels of fallout exceeded 550 kBq m-2, other than thyroid carcinomas. Future increase over the natural incidence of all cancers among the public would be difficult to discern (Anonymous, 1993a, 1996, 2006; WHO, 2006; Eisenbud and Gesell, 1997).
Of the 200,000 persons who were responding to the Chernobyl accident during 1986-1987 (liquidators), existing models estimated 200 fatalities due to leukemia (150 within 10 years), but nothing occurred (Anonymous, 1996, 2006). Two hundred thirty seven of the liquidators were admitted to hospital after they were diagnosed as suffering from clinical syndromes attributable to radiation exposure. Of these, 134 were diagnosed as having acute radiation syndrome; 28 of which died as a consequence of radiation injures within three months; while 26 of the 28 suffered skin lesions that affected over 50% of the whole skin area. gastrointestinal damaged was a serious concern among 11 of them. Over ten years of the accident, 14 persons died, they were not directly attributable to radiation exposures. The other two deaths resulted from trauma (Anonymous, 1993a, 1996, 2006; WHO, 2006; Eisenbud and Gesell, 1997). The increases of thyroid cancer have been observed in children who were born before or within six months of the accident. The incidence of thyroid cancer in children born before six months of the accident drops dramatically to low level expected in unexposed population. To date, 3 children died. For the future: thyroid cancer incident is very difficult to predict. There is a major discrepancy between the number of thyroid cancer appearing in those who were children at the time of accident and the predicted number of such cancers on the bases of standard thyroid dosimetry and current risk projection models. This difference may be result of several factors unique to the accident, which are not typically incorporated into standard models. The increase of incidence of thyroid cancer will most probably persist for several decades (Anonymous, 1993a, 1996, 2006; WHO, 2006; Eisenbud and Gesell, 1997). This led Rohn et al. (1995) to conclude after a pooled analysis of seven studies that the thyroid gland in children has one of the highest risk coefficients of any organ. Also it has been shown that 131I is less effective in producing thyroid cancer than X-rays, with the carcinogenicity of 131I being no more than one third that of external radiation.
Studies in regions affected by 131I releases from Chernobyl accident suggest that thyroid cancer is occurring in children at a rate equivalent to that seen in other studies from external radiation (Beral, 1996).
Over the following years of the accident the principal pathways by which humans were exposed were ingestion of 137Cs and 134Cs in food especially milk and potatoes, although the transfer for radionuclides from soil to milk of cows grazing on meadows varies by a factor of several hundreds (Anonymous, 1993a, 1996, 2006; WHO, 2006; Eisenbud and Gesell, 1997).
Pre-accident data on occurrence of abnormalities in farm animals have been analyzed and comparisons have been made between the frequency of such abnormalities in clean areas and their frequency in areas contaminated by Chernobyl accident. No statistically significant increase in frequency in the contaminated areas has been noted (Anonymous, 1996, 2006).
Eye tissues of rats from the 30-km zone around Chernobyl have been studied using the eyes of intact rats of the same age from Odessa as controls. Significant changes have been found both in cellular elements of the tissues studies and in their extra cellular component of 30 km zone rats (Anonymous, 1996, 2006).
Investigation of birth defect among animals revealed that the incidence of such anomalies in livestock in non-contaminated areas did not differ statistically from analogous from area contaminated by the Chernobyl accident (Anonymous, 1996, 2006).
After TMI accident, the doses from ingested radionuclides were less than that from external radiation. Acting on the assumption that a major radioiodine release occurred, during (1-4) April potassium iodide was supplied (after 5 days of accident). Fortunately, there was no need fore it (Eisenbud and Gesell, 1997).
During the period 1960-1965 the U.S public health services conducted a study of resident who were children during the era of open-air weapon testing. The children were presumed to have consumed fresh milk, Which would have been the major source of radioiodine. The highest exposures were assumed to have been in Washington county, Utah and Lincoln county, Nevada. The results of the survey showed no elevation in neoplasms or other thyroid diseases among the more heavily exposed children (Eisenbud and Gesell, 1997).
After the thermonuclear weapons test of 1 March, 1954 in Bikini Island, the 23 fishermen exposed to fallout from this test were externally affected with Itching and burning sensation and for some of them a diminution in white blood counts was marked. Internal effects were followed-up for 2 person, one died, after 6 month of exposure, of a liver diseases, the result of radiochemical analysis of his tissues were so low, less than 0.1-2 pCi/g, compared with radioactivity content of environmental samples 50 Ci/m2 in their boat. For the second who died 21 years later, radiochemical analysis of lung, liver, spleen, kidney, pancreas and bone were negative for two long lived nuclides of concern 90Sr, 239Pu (Kumatori et al., 1980). Table 1 represents radioactivity distribution in the second diseased person. This particularly noteworthy in view of the heavy deposition on their boat. Follow-up studies of the surviving fishermen were negative for 28 years post accident studies (Eisenbud and Gesell, 1997; Anonymous, 1988).
The nuclear weapons are extremely efficient killing, devastation and incendiary devices. The deaths in Hiroshima and Nagasaki resulted in 20-30% of the cases from primary burns, 50-60% from mechanical injuries, secondary burns and approximately 15% from the radiation injuries. 120,000 persons were killed out right in both cities. In Hiroshima and Nagazaki, 13 and 7 km2 were destroyed respectively. The blast pressure wave caused a sever damage to structures at distance of 2-3 km. Individuals who were close enough to ground zero, to receive a lethal dose of prompt nuclear radiation, were more likely to have been killed out right by the blast or thermal flash (Eisenbud and Gesell, 1997; Anonymous, 1988).
Among the Japanese atomic bomb survivors, the incidence of leukemia reached a peak in the early 1950s and returned to near normal by 1970. By 1987, when half of the irradiated population were still alive, a total of 231 deaths from leukemia were reported among a study sample of about 93000 survivors who comprised the life-span study. Of these cases 156 would have been expected in an unexposed population, leaving an excess of 75 due to radiation induction (Anonymous, 1993a; Eisenbud and Gesell, 1997; Cember, 1987). An excess of 30 cases of thyroid cancer has been reported among Japanese survivors (Anonymous, 1993a).
Table 1: | Distribution of radio activity (pCi/g) in the deceased man |
The 25 year experience of 1292 children who were in utero during bombings, were studied. Although the estimated dose received by part of them was about 2.5 Sv, no increase was found in the incidence of leukemia or other cancers during the first 25 years of life (Anonymous, 1993a; Eisenbud and Gesell, 1997).
The genetic effects of radiation have not been seen in irradiated human populations, even among the two large populations of the atom bomb survivors. Also, experiments with rats indicated that the genetic effects of radiation were less than had been believed and the studies in Japan could find no genetic effects among the offspring of survivors of the atomic bombing. The data indicate that acute radiation effects to moderate doses has a negligible adverse, although the gonads doses are 0.4-2.5 Sv. So a shift of thinking took place and the cancer induction risk became the main concern of health effects of ionizing radiation (Anonymous, 1993a; Eisenbud and Gesell, 1997).
In Nagasaki, many individuals, were in the lower floors of earth-quake proof concrete buildings, were survived with radiation-only injuries, although these buildings were 500 m from the ground zero (Cramer and Slater, 1993).
The above-mentioned facts clarify the wide gab between the predicted and really occurred data related to FP effects on human body, that motivates the to use DAB approach to interpret FP behaviors.
According to DAB approach, the ionization states of the newborn atoms and the long-term high temperature, were not dealt with in an appropriate way and they were the reasons of former models failure (Ajlouni, 2006). This new approach to interpret FP behavior, based on a new hypothesis of ionization states of the fission newborn atoms, which is the High Ionized Atoms (HIA) Hypothesis (Ajlouni and Mahasneh, 2007). This study was conducted mentioned in the Physics Department of Tafila Technical University. HIA approach states that the fission atom destroys, during fission process, due to the large energy released during the process and the differences in electrons binding energy between the initial and final states released during the process, which occurs via three stages. The newborn atoms are highly ionized, 10-12 electrons associated with each nucleus as a result of electrons inertia.
The newborn atoms have a large probability to create bonds between them to form molecules. These bonds are at the inner L, or M shells and are called Deep Atomic Binding. The molecules stay in the reactor at high temperatures for long periods, so they undergo many stages of composition and decomposition to form giant molecules. The molecules formed here are highly attached molecules, as well as giant molecules. These molecules are available in the fuel material and released to the environment, as ordinary or accidental releases (Ajlouni, 2006).
DAB approach will be applied on FP behaviors in the human body and during there way to it and compared with other approaches. This will be discussed in the following part of this section.
According to the former models, radionuclides of FP behavior in human body, is determined by the initial chemical form of the radionuclide entering the ecosystem. The behavior which has been established from biogeochemical pathways analysis is that, a vertical movement in soil, plant uptake via foliage absorption and root uptake and lastly transfer to and metabolism in animals and humans. It is expected, according to these models, a very reactive chemical species moves according soil type and gradients and high uptake ratios by plants, animals and humans of the radionuclides. But, in contrast, deposition of FP after Chernobyl accident was often in non-exchangeable forms. Also a considerable fraction of deposited radionuclides was presented as insoluble in water or neutral solutions (Anonymous, 1993b).
These field observations from Chernobyl, are similar to others from other accidents, highlighted a fact that, there were no ordinary chemical elements, or compounds which undergo ordinary chemical reactions (Anonymous, 1993a) and stress the failure of former models and give evidence to the priority of DAB to interpret this behavior with more reliability. In the cases of animal and human uptake of radionuclides, it is noticed that, a part of uptake nuclides is absorbed within the body and remainder is released outside the body.
Despite of the efforts made by former models to use the chemical similarity between some nuclides with radionuclides, e.g., 90Sr with Ca and 137Cs with K, to interpret and assess the quantities of these radionuclides absorption in animal and human bodies, the field observations are always against them. This is in addition to the difference of absorption between different species, which they refer it to parameters not always understood (Anonymous, 1993b).
But if DAB criterion-which assumes a strong attraction between atoms in the molecule and between the molecules in the giant molecule, make these molecules in non-exchangeable forms-is applied assuming the passive simple diffusion process in the gut, it is easy to understand all non-understandable issues. Then if particles enter the gut (with irradiation through passage) and diffuse through guts wall to blood vessels, the main parameter affect this diffusion is the size of particle. If it is equal or smaller than the gut wall entries, it will pass to blood vessels, as the particle size is smaller, there is a possibility to reach many parts of the body with a rare ionic-exchange process. If it is of larger size, it will never go through guts wall, but release outside the body, with the only risk is irradiation through passing, like what was happened to Chernobyl 14 damaged gastrointestinal tract liquidators.
This explains the differences in measured biological half-lives of the nuclides and the difference in radionuclide absorption between different animal species, e.g. mono-and poly-gastric animals, where the first is better absorber than the latter.
This also explains the milk contamination, that small particles may distribute in milk, when infants drink this milk it already have fine particles which will distribute in infant body and this is the case in small animals. During milk ingestion the contaminating radionuclides irradiate all parts of gastrointestinal tract and other organs, the most sensitive is the thyroid especially in babies who are below six months old. The radionuclides distribution differences in infants and very young animals may guide to different distribution behavior of nutrient nuclides in animals and humans.
DAB approach reduces the reactor accident radiological impact in the environment. The particles in the atmosphere will precipitate, in soil will stay in the upper layers and in water will be sedimented, so we can go to our objectives, even during a major accident like Chernobyl, concerning radiation safety directly. Lastly the radionuclides will stay on soil surface and on sea bedrock as particles and will never be available in ionic forms which reduces it is mobility and then it is danger on living species. This also reduces the expected potential risk associated with nuclear energy industry and, for faraway, the radiophobia.
Radiation protections measures during and after accident (e.g., evacuation of affected people, providing relief,...etc) may be directed in a better way and the expenses of these measures will reduced.
According to DAB, we can differentiate between the chemical behavior of FP, irradiation products and natural radioactive materials. The latest are the most easily to deal with, while the second is a little difficult arises when dealing with, whereas it is too difficult to deal chemically with FP. Ignoring these differences in chemical behavior of deferent radionuclides is the most important reason of failure of the former models during FP modeling in the laboratory. The above mentioned results are highly correlated with the latest reviews and findings (Anonymous, 1996, 2006).
DAB approach introduces molecules never be available in ionic forms, which reduce their mobility and then their potential risk on living species. According to DAB, The radionuclides have reduced mobility and potential risk on human body. Thus reactor accident radiological impact in the environment is minor. This also reduces the expected potential risk associated with nuclear energy industry and, for faraway, the radio-phobia. Radiation protection measures during and after nuclear emergencies may be directed in a better way and the expenses of these measures will be reduced.