Hadi Fathi Moghaddam
Department of Physiology, School of Medicine and Physiology Research Center,
Aliasghar Hemmati
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran
Zahra Nazari
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran
Hasan Mehrab
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahwaz Jondishapour University of Medical Sciences, Ahwaz, Iran
Khosro M. Abid
Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy,
Tehran University of Medical Sciences, Tehran, Iran
Mehdi Shafiee Ardestani
Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy,
Tehran University of Medical Sciences, Tehran, Iran
ABSTRACT
Parkinson`s disease (PD) is a degenerative neurodopaminergic disease in nigrostriatum pathway of human and is responsible for most of the movement disorders. Increasing evidence suggests that an inflammatory reaction accompanies the pathological processes caused by Cyclooxygenase (COX) seen in many neurodegenerative disorders, including PD and according to the recent researches chronic use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) decreases the risk of PD in human. In the study the rat left Substantia Nigra Pars Compacta (SNc) have been destroyed using electrical lesion (1 mA; DC; 8 Sec) to induce PD model. Then aspirin (30, 60 mg kg-1) and celecoxib (4, 8 mg kg-1) have been administrated orally to parkinsonian rats. When the animals were suffered to PD Murprogo`s Method evaluated the rigidity of parkinsonian rats. Both selective COX-2 inhibitor (celecoxib) and non-selective COX-2 inhibitor (aspirin) decreased the rigidity of parkinsonian rats p< 0.05 but rigidity recovery after administration the selective COX-2 inhibitor was more than non-selective COX-2 inhibitor. These findings are additional pharmacological information which has suggested the use of NSAIDs as alternative way to treat the rigidity of PD.
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How to cite this article
Hadi Fathi Moghaddam, Aliasghar Hemmati, Zahra Nazari, Hasan Mehrab, Khosro M. Abid and Mehdi Shafiee Ardestani, 2007. Effects of Aspirin and Celecoxib on Rigidity in a Rat Model of Parkinson`s Disease. Pakistan Journal of Biological Sciences, 10: 3853-3858.
DOI: 10.3923/pjbs.2007.3853.3858
URL: https://scialert.net/abstract/?doi=pjbs.2007.3853.3858
DOI: 10.3923/pjbs.2007.3853.3858
URL: https://scialert.net/abstract/?doi=pjbs.2007.3853.3858
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