Daniel Agriva Tamba
Department of Biochemistry,Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
Arta Farmawati
Department of Biochemistry,Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
Rita Cempaka
Department of Anatomic Pathology, Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
Yogik Onky Silvana Wijaya
Department of Biochemistry,Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
Haryo Bismantara
Department of Biochemistry,Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
Aria Danurdoro
Department of Biochemistry,Faculty of Medicine, Gadjah Mada University, Yogyakarta-55281, Indonesia
ABSTRACT
Cardiovascular disease was the most lethal disease in the world. Atherosclerosis was one of the factor that can lead to the development of cardiovascular disease. Low density lipoprotein (LDL) and high density lipoprotein (HDL) were often associated with atherosclerosis. LDL and HDL concentration can be modified by diet, such as capsaicin and vitamin E. In this study, 25 male Sprague Dawley rats were divided into 5 group, A, B, C, D and E. Each group had 5 rats. Group B, C, D, and E were rendered high fat diet (A.D. II standard diet, 10% lard, olive oil and yolk) for 14 days while group A was given standard diet. Group B was positive control and get no treatment, group C was given 1 mg/kg capsaicin for 14 days, group D was given 22 IU vitamin E. LDL and HDL concentration were measured before and after the treatment. LDL concentration decreased significantly and HDL concentration increased insignificantly after capsaicin treatment. LDL and HDL concentration were significantly increase after given 22 IU vitamin E. Combination of 1 mg/kg capsaicin and 22 IU vitamin E could also improve HDL concentration and reduce LDL concentration. Vitamin E gave the best effect when compare with capsaicin alone and the combination of capsaicin and vitamin E in increasing HDL concentration and reducing LDL concentration.
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How to cite this article
Daniel Agriva Tamba, Arta Farmawati, Rita Cempaka, Yogik Onky Silvana Wijaya, Haryo Bismantara and Aria Danurdoro, 2014. Combination of Capsaicin and Vitamin E Increase HDL and Decrease LDL Levels in Hypercholesterolemic Rats. Pakistan Journal of Nutrition, 13: 521-526.
DOI: 10.3923/pjn.2014.521.526
URL: https://scialert.net/abstract/?doi=pjn.2014.521.526
DOI: 10.3923/pjn.2014.521.526
URL: https://scialert.net/abstract/?doi=pjn.2014.521.526
REFERENCES
- Belza, A., E. Frandsen and J. Kondrup, 2006. Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: A placebo-controlled, double-blind 8-week intervention in obese subjects. Int. J. Obesity, 31: 121-130.
CrossRefDirect Link - Briel, M., I. Ferreira-Gonzalez, J.J. You, P.J. Karanicolas and E.A. Akl et al., 2009. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: Systematic review and meta-regression analysis. Biol. Med. J., Vol. 338.
CrossRef - Chin, S.F., J. Ibahim, S. Makpol, N.A. Abdul Hamid and A. Abdul Latiff et al., 2011. Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study. Nutr. Metab. (Lond.), Vol. 8.
Direct Link - Daniels, T.F., K.M. Killinger, J.J. Michal, R.W. Wright Jr. and Z. Jiang, 2009. Lipoproteins, cholesterol homeostasis and cardiac health. Int. J. Biol. Sci., 5: 474-488.
CrossRefPubMedDirect Link - Hodis, H.N., W.J. Mack, L. LaBree, P.R. Mahrer and A. Sevanian et al., 2002. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis the Vitamin E atherosclerosis prevention study (VEAPS). Circulation, 106: 1453-1459.
CrossRefDirect Link - Hursel, R. and M.S. Westerterp-Plantenga, 2010. Thermogenic ingredients and body weight regulation. Int. J. Obesity, 34: 659-669.
CrossRefDirect Link - Kawada, T., K. Hagihara and K. Iwai, 1986. Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J. Nutr., 116: 1272-1278.
Direct Link - Ma, L., J. Zhong, Z. Zhao, Z. Luo and S. Ma et al., 2011. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovascular Res., 92: 504-513.
CrossRefDirect Link - Mahley, R.W., T.L. Innerarity, S.C. Rall Jr. and K.H. Weisgraber, 1984. Plasma lipoproteins: Apolipoprotein structure and function. J. Lipid Res., 25: 1277-1294.
Direct Link - Mangravite, L.M., S. Chiu, K. Wojnoonski, R.S. Rawlings, N. Bergeron and R.M. Krauss, 2011. Changes in atherogenic dyslipidemia induced by carbohydrate restriction in men are dependent on dietary protein source. J. Nutr., 141: 2180-2185.
CrossRefDirect Link - Mooradian, A.D., M.J. Haas and N.C. Wong, 2006. The effect of select nutrients on serum high-density lipoprotein cholesterol and apolipoprotein AI levels. Endocrine Rev., 27: 2-16.
CrossRef - Negulesco, J.A., S.A. Noel, H.A.I. Newman, E.C. Naber, H.B. Bhat and D.T. Witiak, 1987. Effects of pure capsaicinoids (capsaicin and dihydrocapsaicin) on plasma lipid and lipoprotein concentrations of turkey poults. Atherosclerosis, 64: 85-90.
CrossRefDirect Link - Piao, M.J., E.S. Yoo, Y.S. Koh, H.K. Kang and J. Kim et al., 2011. Antioxidant effects of the ethanol extract from flower of Camellia japonica via scavenging of reactive oxygen species and induction of antioxidant enzymes. Int. J. Mol. Sci., 12: 2618-2630.
CrossRefDirect Link - Rainwater, D.L., M.C. Mahaney, J.L. VandeBerg and X.L. Wang, 2007. Vitamin E dietary supplementation significantly affects multiple risk factors for cardiovascular disease in baboons. Am. J. Clin. Nutr., 86: 597-603.
Direct Link - Shargorodsky, M., O. Debby, Z. Matas and R. Zimlichman, 2010. Research effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr. Metab., Vol. 7.
Direct Link - Shubha, M.C., R.R. Reddy and K. Srinivasan, 2011. Antilithogenic influence of dietary capsaicin and curcumin during experimental induction of cholesterol gallstone in mice. Applied Physiol. Nutr. Metab., 36: 201-209.
CrossRefDirect Link - Sola, R., R.M. Valls, G. Godas, G. Perez-Busquets and J. Ribalta et al., 2012. Cocoa, hazelnuts, sterols and soluble fiber cream reduces lipids and inflammation biomarkers in hypertensive patients: A randomized controlled trial. PloS One, Vol. 7.
CrossRef - Walldius, G. and I. Jungner, 2004. Apolipoprotein B and apolipoprotein A‐I: Risk indicators of coronary heart disease and targets for lipid‐modifying therapy. J. Internal Med., 255: 188-205.
CrossRef - Westerterp-Plantenga, M.S., V. Rolland, S.A.J. Wilson and K.R. Westerterp, 1999. Satiety related to 24 h diet-induced thermogenesis during high protein/carbohydrate vs high fat diets measured in a respiration chamber. Eur. J. Clin. Nutr., 53: 495-502.
Direct Link - Wolvetang, E.J., J.A. Larm, P. Moutsoulas and A. Lawen, 1996. Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell Growth Differentiation: Mol. Biol. J. Am. Assoc. Cancer Res., 7: 1315-1325.
Direct Link - Yanai, N., S. Shiotani, S. Hagiwara, H. Nabetani and M. Nakajima, 2008. Antioxidant combination inhibits reactive oxygen species mediated damage. Biosci. Biotechnol. Biochem., 72: 3100-3106.
CrossRefDirect Link