Aziouz Aidoud
Department of Agro-Food Sciences, University of Blidal, Algeria
Omar Elahcene
Department of Biology, University of Djelfa, Algeria
Ali Ammouche
Department of Food Technology and Human Nutrition, National High College of Agronomy, El-Harrach, Algeria
Ana B. Rodriguez
Department of Physiology, Faculty of Science, University of Extremadura, Spain
ABSTRACT
Lycopene, the most important carotenoids, is a red lipophilic pigment containing 11 conjugated double bonds make lycopene a powerful radical scavenger. It has the powerful antioxidant activity within carotenoids and is an effective free radical scavenger. Virgin olive oil (VOO) and argan oil (AO) contain a wide variety of phytochemicals which are considered as a functional foods. The present study intended to assess the effect of various dietary VOO and AO in combination with lycopene consumption on some liver function parameters, including liver enzymes such as alanine amino-transferase (ALT), aspartate-aminotransferase (AST), alkaline phosphatase (ALP) as well as on hepatic lycopene concentration of wistar rats. Results showed that ingestion of VOO and AO diminished ALT, AST, ALP levels in all the groups assayed. The lycopen enrichment VOO and AO significantly improved the beneficial effects derived from the consumption of both oils on serum liver enzymes and protect the liver tissue by enhancing the hepatic lycopene concentration, induced hepatoprotective effect by ameliorating the capacity antioxidant and function parameters of the liver tissue in wistar rats. These results suggest that the inclusion of lycopene in VOO and AO may be used as a natural antioxidant to protect the liver against damage.
PDF References Citation
How to cite this article
Aziouz Aidoud, Omar Elahcene, Ali Ammouche and Ana B. Rodriguez, 2016. Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats. Pakistan Journal of Nutrition, 15: 347-351.
DOI: 10.3923/pjn.2016.347.351
URL: https://scialert.net/abstract/?doi=pjn.2016.347.351
DOI: 10.3923/pjn.2016.347.351
URL: https://scialert.net/abstract/?doi=pjn.2016.347.351
REFERENCES
- Aidoud, A., A. Ammouche, M. Garrido and A.B. Rodriguez, 2014. Effect of lycopene-enriched olive and argan oils upon lipid serum parameters in Wistar rats. J. Sci. Food Agric., 94: 2943-2950.
CrossRefDirect Link - Bergmeyer, H.U., M. Horder and R. Rej, 1986. International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 3. IFCC method for alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2). J. Clin. Chem. Clin. Biochem., 24: 481-495.
PubMedDirect Link - Gitenay, D., B. Lyan, M. Rambeau, A. Mazur and E. Rock, 2007. Comparison of lycopene and tomato effects on biomarkers of oxidative stress in vitamin E deficient rats. Eur. J. Nutr., 46: 468-475.
CrossRefDirect Link - Hochgraf, E., S. Mokady and U. Cogan, 1997. Dietary oxidized linoleic acid modifies lipid composition of rat liver microsomes and increases their fluidity. J. Nutr., 127: 681-686.
PubMedDirect Link - Kujawska, M., E. Ignatowicz, M. Ewertowska, J. Markowski and J. Jodynis-Liebert, 2011. Cloudy apple juice protects against chemical-induced oxidative stress in rat. Eur. J. Nutr., 50: 53-60.
CrossRefDirect Link - Kujawska, M., E. Ignatowicz, M. Murias, M. Ewertowska, K. Mikolajczyk and J. Jodynis-Liebert, 2009. Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats. J. Agric. Food Chem., 57: 2570-2575.
CrossRefDirect Link - Lee, A., D.I. Thurnham and M. Chopra, 2000. Consumption of tomato products with olive oil but not sunflower oil increases the antioxidant activity of plasma. Free Radic. Biol. Med., 29: 1051-1055.
CrossRefPubMedDirect Link - Melendez-Martinez, A.J., A.F. Nascimento, Y. Wang, C. Liu, Y. Mao and X.D. Wang, 2013. Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary Surg. Nutr., 2: 198-208.
CrossRefDirect Link - Miller, K.W., N.A. Lorr and C.S. Yang, 1984. Simultaneous determination of plasma retinol, α-tocopherol, lycopene, α-carotene and β-carotene by high-performance liquid chromatography. Anal. Biochem., 138: 340-345.
CrossRefDirect Link - Novak, T.E., T.A. Babcock, D.H. Jho, W.S. Helton and N.J. Espat, 2003. NF-κB inhibition by ω-3 fatty acids modulates LPS-stimulated macrophage TNF-α transcription. Am. J. Physiol.-Lung Cell. Mol. Physiol., 284: L84-L89.
CrossRefPubMedDirect Link - Poojari, R., S. Gupta, G. Maru, B. Khade and S. Bhagwat, 2010. Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver. Asian Pac. J. Cancer Prev., 11: 1015-1020.
Direct Link - Sanchez-Muniz, F.J., S. Lopez-Varela, M.C. Garrido-Polonio and C. Cuesta, 1998. Dietary effects on growth, liver peroxides and serum and lipoprotein lipids in rats fed a thermoxidised and polymerised sunflower oil. J. Sci. Food Agric., 76: 364-372.
CrossRefDirect Link - Simopoulos, A.P., 2005. What is so special about the diet of Greece? The scientific evidence. Nutr. Fitness, 95: 80-92.
CrossRefDirect Link - Choi, S.K. and J.S. Seo, 2013. Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils. Nutr. Res. Pract., 7: 26-33.
CrossRefDirect Link - Stahl, W. and H. Sies, 2003. Antioxidant activity of carotenoids. Mol. Aspects Med., 24: 345-351.
CrossRefPubMedDirect Link - Li, S., H.Y. Tan, N. Wang, Z.J. Zhang, L. Lao, C.W. Wong and Y. Feng, 2015. The role of oxidative stress and antioxidants in liver diseases. Int. J. Mol. Sci., 16: 26087-26124.
CrossRefDirect Link - Tietz, N.W., C.A. Burtis, P. Duncan, K. Ervin, C.J. Petitclerc, A.D. Rinker, D. Shuey and E.R. Zygowicz, 1983. A reference method for measurement of alkaline phosphatase activity in human serum. Clin. Chem., 29: 751-761.
Direct Link - Tso, P., T. Lee and S.J. DeMichele, 2001. Randomized structured triglycerides increase lymphatic absorption of tocopherol and retinol compared with the equivalent physical mixture in a rat model of fat malabsorption. J. Nutr., 131: 2157-2163.
Direct Link - Unlu, N.Z., T. Bohn, S.K. Clinton and S.J. Schwartz, 2005. Carotenoid absorption from salad and salsa by humans is enhanced by the addition of avocado or avocado oil. J. Nutr., 135: 431-436.
PubMedDirect Link - Varela, G. and B. Ruiz-Rosso, 1998. Influence of the frying process on the real fat intake. Grasas Aceites, 49: 366-369.
CrossRefDirect Link