A. Godinez-Oviedo
Instituto de Ciencias Agropecuarias, Rancho Universitario, Universidad Autonoma del Estado de Hidalgo, Av. Universidad Km. 1, Ex Hacienda Aquetzalpa, Apartado Postal No. 32, Tulancingo, Hgo, Mexico
N. Guemes-Vera
Instituto de Ciencias Agropecuarias, Rancho Universitario, Universidad Autonoma del Estado de Hidalgo, Av. Universidad Km. 1, Ex Hacienda Aquetzalpa, Apartado Postal No. 32, Tulancingo, Hgo, Mexico
O.A. Acevedo-Sandoval
Instituto de Ciencias Agropecuarias, Rancho Universitario, Universidad Autonoma del Estado de Hidalgo, Av. Universidad Km. 1, Ex Hacienda Aquetzalpa, Apartado Postal No. 32, Tulancingo, Hgo, Mexico
ABSTRACT
Moringa oleifera Lam. is a plant that is known for its nutritional value and particularly for its protein quantity and quality. Due to its nutrient constitution, M. oleifera is used in several regions to treat malnutrition, especially in children. Moreover, M. oleifera contains phytochemical compounds that have important biological activities. Several previous studies confirmed that extracts or compounds isolated from M. oleifera have antioxidant, anti-carcinogenic, anti-diabetic, anti-inflammatory and anti-hypertensive properties, as well as the ability to protect against hepatic damage. This review discusses the characteristics and potential benefits of M. oleifera nutrients and phytochemicals.
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How to cite this article
A. Godinez-Oviedo, N. Guemes-Vera and O.A. Acevedo-Sandoval, 2016. Nutritional and Phytochemical Composition of Moringa oleifera Lam and its Potential Use as Nutraceutical Plant: A Review. Pakistan Journal of Nutrition, 15: 397-405.
DOI: 10.3923/pjn.2016.397.405
URL: https://scialert.net/abstract/?doi=pjn.2016.397.405
DOI: 10.3923/pjn.2016.397.405
URL: https://scialert.net/abstract/?doi=pjn.2016.397.405
REFERENCES
- Abdulkarim, S.M., K. Long, O.M. Lai, S.K.S. Muhammad and H.M. Ghazali, 2005. Some physico-chemical properties of moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods. Food Chem., 93: 253-263.
CrossRefDirect Link - Abdulkarim, S.M., K. Long, O.M. Lai, S.K.S. Muhammad and H.M. Ghazali, 2007. Frying quality and stability of high-oleic Moringa oleifera seed oil in comparison with other vegetable oils. Food Chem., 105: 1382-1389.
CrossRefDirect Link - Adedapo, A.A., O.M. Mogbojuri and B.O. Emikpe, 2009. Safety evaluations of the aqueous extract of the leaves of Moringa oleifera in rats. J. Med. Plants Res., 3: 586-591.
Direct Link - Akinlolu, A.A., O.K. Ghazali, O.M. Ameen, S.C. Oyebanji, G.O. Omotoso and B.U. Enaibe, 2014. Moringa oleifera impairs the morphology and functions of the kidney in adult wistar rats. Int. J. Morphol., 32: 469-474.
CrossRefDirect Link - Alhakmani, F., S. Kumar and S.A. Khan, 2013. Estimation of total phenolic content, in-vitro antioxidant and anti-inflammatory activity of flowers of Moringa oleifera. Asian Pac. J. Trop. Biomed., 3: 623-627.
CrossRefDirect Link - Al‐Said, M.S., R.A. Mothana, M.A. Al‐Yahya, A.S. Al‐Blowi, M. Al‐Sohaibani, A.F. Ahmed and S. Rafatullah, 2012. Edible oils for liver protection: Hepatoprotective potentiality of Moringa oleifera seed oil against chemical‐induced hepatitis in rats. J. Food Sci., 77: T124-T130.
CrossRefDirect Link - Anjorin, T.S., P. Ikokoh and S. Okolo, 2010. Mineral composition of Moringa oleifera leaves, pods and seeds from two regions in Abuja, Nigeria. Int. J. Agric. Biol., 12: 431-434.
Direct Link - Anwar, F. and M.I. Bhanger, 2003. Analytical characterization of Moringa oleifera seed oil grown in temperate regions of Pakistan. J. Agric. Food Chem., 51: 6558-6563.
CrossRefPubMedDirect Link - Anwar, F., M. Ashraf and M.I. Bhanger, 2005. Interprovenance variation in the composition of Moringa oleifera oilseeds from Pakistan. J. Am. Oil Chem. Soc., 82: 45-51.
CrossRefDirect Link - Anwar, F., S. Latif, M. Ashraf and A.H. Gilani, 2007. Moringa oleifera: A food plant with multiple medicinal uses. Phytother. Res., 21: 17-25.
CrossRefPubMedDirect Link - Ashfaq, M., S.M.A. Basra and U. Ashfaq, 2012. Moringa: A miracle plant for agro-forestry. J. Agric. Soc. Sci., 8: 115-122.
Direct Link - Aslam, M., F. Anwar, R. Nadeem, U. Rashid, T.G. Kazi and M. Nadeem, 2005. Mineral composition of Moringa oleifera leaves and pods from different regions of Punjab, Pakistan. Asian J. Plant Sci., 4: 417-421.
CrossRefDirect Link - Atawodi, S.E., J.C. Atawodi, G.A. Idakwo, B. Pfundstein and R. Haubner et al., 2010. Evaluation of the polyphenol content and antioxidant properties of methanol extracts of the leaves, stem and root barks of Moringa oleifera Lam. J. Med. Food, 13: 710-716.
CrossRefDirect Link - Banerji, R., S.C. Verma and P. Pushpendra, 2003. Oil potential of Moringa. Nat. Prod. Radiance, 2: 68-69.
Direct Link - Bennett, R.N., F.A. Mellon, N. Foidl, J.H. Pratt, M.S. Dupont, L. Perkibns and P.A. Kroon, 2003. Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L. J. Agric. Food Chem., 51: 3546-3553.
CrossRefPubMedDirect Link - Berkovich, L., G. Earon, I. Ron, A. Rimmon, A. Vexler and S. Lev-Ari, 2013. Moringa Oleifera aqueous leaf extract down-regulates nuclear factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic cancer cells. BMC Complementary Altern. Med., Vol. 13.
CrossRefDirect Link - Bharali, R., J. Tabassum and M.R. Azad, 2003. Chemomodulatory effect of Moringa oleifera, Lam, on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice. Asian Pac. J. Cancer Prev., 4: 131-139.
PubMedDirect Link - Teixeira, E.M.B., M.R.B. Carvalho, V.A. Neves, M.A. Silva and L. Arantes-Pereira, 2014. Chemical characteristics and fractionation of proteins from Moringa oleifera Lam. leaves. Food Chem., 147: 51-54.
CrossRefDirect Link - Cheenpracha, S., E.J. Park, W.Y. Yoshida, C. Barit, M. Wall, J.M. Pezzuto and L.C. Chang, 2010. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg. Med. Chem., 18: 6598-6602.
CrossRefDirect Link - Chumark, P., P. Khunawat, Y. Sanvarinda, S. Phornchirasilp and N.P. Morales et al., 2008. The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. J. Ethnopharmacol., 116: 439-446.
CrossRefPubMedDirect Link - Costa-Lotufo, L.V., M.T.H. Khan, A. Ather, D.V. Wilke and P.C. Jimenez et al., 2005. Studies of the anticancer potential of plants used in Bangladeshi folk medicine. J. Ethnopharmacol., 99: 21-30.
CrossRefPubMedDirect Link - Das, N., K. Sikder, S. Ghosh, B. Fromenty and S. Dey, 2012. Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet. Indian J. Exp. Biol., 50: 404-412.
PubMedDirect Link - Dhakar, R.C., S.D. Maurya, B.K. Pooniya, N. Bairwa and M. Gupta, 2011. Moringa: The herbal gold to combat malnutrition. Chron. Young Sci., 2: 119-125.
CrossRefDirect Link - Fahey, J.W., 2005. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees Life J., Vol. 1.
Direct Link - Faizi, S., B.S. Siddiqui, R. Saleem, K. Aftab, F. Shaheen and A.H. Gilani, 1998. Hypotensive constituents from the pods of Moringa oleifera. Planta Med., 64: 225-228.
CrossRefPubMedDirect Link - Faizi, S., B.S. Siddiqui, R. Saleem, S. Siddiqui and K. Aftab et al., 1994. Isolation and structure elucidation of new nitrile and mustard oil glycosides from moringa oleifera and their effect on blood pressure. J. Nat. Prod., 57: 1256-1261.
CrossRefPubMedDirect Link - Faizi, S., B.S. Siddiqui, R. Saleem, S. Siddiqui, K. Aftab and A.H. Gilani, 1995. Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera. Phytochemistry, 38: 957-963.
CrossRefPubMedDirect Link - Fakurazi, S., I. Hairuszah and U. Nanthini, 2008. Moringa oleifera lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food Chem. Toxicol., 46: 2611-2615.
CrossRefDirect Link - Fakurazi, S., U. Nanthini and H. Ithnin, 2008. Hepatoprotective and antioxidant action of Moringa oleifera Lam. againsts acetaminophen induced hepatoxicity in rats. Int. J. Pharm., 4: 270-275.
Direct Link - Ferreira, P.M.P., D.F. Farias, J.T.D.A. Oliveira and A.D.F.U. Carvalho, 2008. Moringa oleifera: Bioactive compounds and nutritional potential. Rev. Nutr., 21: 431-437.
CrossRefDirect Link - Ghasi, S., E. Nwobodo and J.O. Ofili, 2000. Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. J. Ethnopharmacol., 69: 21-25.
CrossRefPubMedDirect Link - Guevara, A.P., C. Vargas, H. Sakurai, Y. Fujiwara and K. Hashimoto et al., 1999. An antitumor promoter from Moringa oleifera Lam. Mutat. Res./Genet. Toxicol. Environ. Mutagen., 440: 181-188.
CrossRefDirect Link - Gupta, R., M. Mathur, V.K. Bajaj, P. Katariya, S. Yadav, R. Kamal and R.S. Gupta, 2012. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J. Diabetes, 4: 164-171.
CrossRefDirect Link - Hamza, A.A., 2010. Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem. Toxicol., 48: 345-355.
CrossRefPubMedDirect Link - Hukkeri, V.I., C.V. Nagathan, R.V. Karadi and B.S. Patil, 2006. Antipyretic and wound healing activities of Moringa oleifera Lam. in rats. Indian J. Pharm. Sci., 68: 124-126.
CrossRefDirect Link - Iqbal, S. and M.I. Bhanger, 2006. Effect of season and production location on antioxidant activity of Moringa oleifera leaves grown in Pakistan. J. Food Comp. Anal., 19: 544-551.
CrossRefDirect Link - Jain, P.G., S.D. Patil, N.G. Haswani, M.V. Girase and S.J. Surana, 2010. Hypolipidemic activity of Moringa oleifera Lam., Moringaceae, on high fat diet induced hyperlipidemia in albino rats. Revista Brasileira de Farmacognosia, 20: 969-973.
CrossRefDirect Link - Jaiswal, D., P.K. Rai, A. Kumar, S. Mehta and G. Watal, 2009. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J. Ethnopharmacol., 123: 392-396.
CrossRefPubMedDirect Link - Jaiswal, D., P.K. Rai, S. Mehta, S. Chatterji and S. Shukla et al., 2013. Role of Moringa oleifera in regulation of diabetes-induced oxidative stress. Asian Pacific J. Trop. Med., 6: 426-432.
CrossRefDirect Link - Jung, I.L., 2014. Soluble extract from Moringa oleifera leaves with a new anticancer activity. PloS ONE, Vol. 9.
CrossRefDirect Link - Karadi, R.V., N.B. Gadge, K.R. Alagawadi and R.V. Savadi, 2006. Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats. J. Ethnopharmacol., 105: 306-311.
CrossRefPubMedDirect Link - Kashiwada, Y., F.A. Ahmed, S.I. Kurimoto, S.Y. Kim, H. Shibata, T. Fujioka and Y. Takaishi, 2012. New α-glucosides of caffeoyl quinic acid from the leaves of Moringa oleifera Lam. J. Nat. Med., 66: 217-221.
CrossRefDirect Link - Kasolo, J.N., G.S. Bimenya, L. Ojok, J. Ochieng and J.W. Ogwal-Okeng, 2010. Phytochemicals and uses of Moringa oleifera leaves in Ugandan rural communities. J. Med. Plants Res., 4: 753-757.
Direct Link - Kumar, N.A. and L. Pari, 2003. Antioxidant action of Moringa oleifera Lam. (Drumstick) against antitubercular drugs induced lipid peroxidation in rats. J. Med. Food, 6: 255-259.
CrossRefPubMedDirect Link - Kumari, D.J., 2010. Hypoglycaemic effect of Moringa oleifera and Azadirachta indica in type 2 diabetes mellitus. Bioscan, 5: 211-214.
Direct Link - Kumbhare, M.R., V. Guleha and T. Sivakumar, 2012. Estimation of total phenolic content, cytotoxicity and in-vitro antioxidant activity of stem bark of Moringa oleifera. Asian Pac. J. Trop. Dis., 2: 144-150.
CrossRefDirect Link - Lalas, S. and J. Tsaknis, 2002. Characterization of Moringa oleifera seed oil variety Periyakulam 1. J. Food Compos. Anal., 15: 65-77.
CrossRefDirect Link - Lalas, S. and J. Tsaknis, 2002. Extraction and identification of natural antioxidant from the seeds of the Moringa oleifera tree variety of Malawi. J. Am. Oil Chem. Soc., 79: 677-683.
CrossRefDirect Link - Mahajan, S.G., R.G. Mali and A.A. Mehta, 2007. Protective effect of ethanolic extract of seeds of Moringa oleifera Lam. against inflammation associated with development of arthritis in rats. J. Immunotoxicol., 4: 39-47.
CrossRefDirect Link - Makkar, H.P.S. and K. Becker, 1996. Nutrional value and antinutritional components of whole and ethanol extracted Moringa oleifera leaves. Anim. Feed Sci. Technol., 63: 211-228.
CrossRefDirect Link - Mehta, A. and B. Agrawal, 2008. Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity. Orient. Pharm. Exp. Med., 8: 24-31.
Direct Link - Mehta, L.K., R. Balaraman, A.H. Amin, P.A. Bafna and O.D. Gulati, 2003. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J. Ethnopharmacol., 86: 191-195.
CrossRefPubMedDirect Link - Mensah, J.K., B. Ikhajiagbe, N.E. Edema and J. Emokhor, 2012. Phytochemical, nutritional and antibacterial properties of dried leaf powder of Moringa oleifera (Lam) from Edo Central province, Nigeria. J. Nat. Plant Resour., 2: 107-112.
Direct Link - Morton, J.F., 1991. The horseradish tree, Moringa pterygosperma (Moringaceae): A boon to arid lands? Econ. Bot., 45: 318-333.
CrossRefDirect Link - Moyo, B., P.J. Masika, A. Hugo and V. Muchenje, 2011. Nutritional characterization of Moringa (Moringa oleifera Lam.) leaves. Afr. J. Biotechnol., 10: 12925-12933.
Direct Link - Muangnoi, C., P. Chingsuwanrote, P. Praengamthanachoti, S. Svasti and S. Tuntipopipat, 2012. Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines. Inflammation, 35: 445-455.
CrossRefDirect Link - Ndong, M., M. Uehara, S.I. Katsumata and K. Suzuki, 2007. Effects of oral administration of Moringa oleifera Lam on glucose tolerance in Goto-Kakizaki and Wistar rats. J. Clin. Biochem. Nutr., 40: 229-233.
CrossRefDirect Link - Nikkon, F., Z.A. Saud, M.H. Rahman and M.E. Haque, 2003. In vitro antimicrobial activity of the compound isolated from chloroform extract of Moringa oleifera Lam. Pak. J. Biol. Sci., 6: 1888-1890.
CrossRefDirect Link - Oduro, I., W.O. Ellis and D. Owusu, 2008. Nutritional potential of two leafy vegetables: Moringa oleifera and Ipomoea batatas leaves. Sci. Res. Essay, 3: 57-60.
CrossRefDirect Link - Ogbunugafor, H.A., F.U. Eneh, A.N. Ozumba, M.N. Igwo-Ezikpe and J. Okpuzor et al., 2011. Physico-chemical and antioxidant properties of Moringa oleifera seed oil. Pak. J. Nutr., 10: 409-414.
CrossRefDirect Link - Oliveira, J.T.A., S.B. Silveira, I.M. Vasconcelos, B.S. Cavada and R.A. Moreira, 1999. Compositional and nutritional attributes of seeds from the multiple purpose tree Moringa oleifera Lamarck. J. Sci. Food Agric., 79: 815-820.
CrossRefDirect Link - Manguro, L.O.A. and P. Lemmen, 2007. Phenolics of Moringa oleifera leaves. Nat. Prod. Res., 21: 56-68.
CrossRefDirect Link - Pari, L. and N.A. Kumar, 2002. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J. Med. Food, 5: 171-177.
CrossRefDirect Link - Pari, L. and N.A. Kumar, 2002. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J. Med. Food, 5: 171-177.
CrossRefDirect Link - Ramachandran, C., K.V. Peter and P.K. Gopalakrishnan, 1980. Drumstick (Moringa oleifera): A multipurpose Indian vegetable. Econ. Bot., 34: 276-283.
CrossRefDirect Link - Rashid, U., F. Anwar, B.R. Moser and G. Knothe, 2008. Moringa oleifera oil: A possible source of biodiesel. Bioresour. Technol., 99: 8175-8179.
CrossRefPubMedDirect Link - Richter, N., P. Siddhuraju and K. Becker, 2003. Evaluation of nutritional quality of moringa (Moringa oleifera Lam.) leaves as an alternative protein source for Nile tilapia (Oreochromis niloticus L.). Aquaculture, 217: 599-611.
CrossRefDirect Link - Sashidhara, K.V., J.N. Rosaiah, E. Tyagi, R. Shukla, R. Raghubir and S.M. Rajendran, 2009. Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. Eur. J. Med. Chem., 44: 432-436.
CrossRefDirect Link - Siddhuraju, P. and K. Becker, 2003. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J. Agric. Food Chem., 51: 2144-2155.
CrossRefPubMedDirect Link - Singh, B.N., B.R. Singh, R.L. Singh, D. Prakash, R. Dhakarey, G. Upadhyay and H.B. Singh, 2009. Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera. Food Chem. Toxicol., 47: 1109-1116.
CrossRefDirect Link - Singh, R.S.G., P.S. Negi and C. Radha, 2013. Phenolic composition, antioxidant and antimicrobial activities of free and bound phenolic extracts of Moringa oleifera seed flour. J. Funct. Foods, 5: 1883-1891.
CrossRefDirect Link - Sreelatha, S. and P.R. Padma, 2009. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant Foods Hum. Ntur., 64: 303-311.
CrossRefPubMedDirect Link - Sreelatha, S. and P.R. Padma, 2010. Protective mechanisms of Moringa oleifera against CCl4-induced oxidative stress in precision-cut liver slices. Forschende Komplementarmedizin, 17: 189-194.
CrossRefDirect Link - Sreelatha, S., A. Jeyachitra and P.R. Padma, 2011. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food Chem. Toxicol., 49: 1270-1275.
CrossRefDirect Link - Verma, A.R., M. Vijayakumar, C.S. Mathela and C.V. Rao, 2009. In vitro and in vivo antioxidant properties of different fractions of Moringa oleifera leaves. Food Chem. Toxicol., 47: 2196-2201.
CrossRefPubMedDirect Link - Vongsak, B., P. Sithisarn, S. Mangmool, S. Thongpraditchote, Y. Wongkrajang and W. Gritsanapan, 2013. Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Ind. Crop Prod., 44: 566-571.
CrossRefDirect Link - Zvinorova, P.I., L. Lekhanya, K. Erlwanger and E. Chivandi, 2015. Dietary effects of Moringa oleifera leaf powder on growth, gastrointestinal morphometry and blood and liver metabolites in Sprague Dawley rats. J. Anim. Physiol. Anim. Nutr., 99: 21-28.
CrossRefDirect Link