Aim of this study was to investigate the effects of Grape Seed Extract (GSE), as a potent antioxidant on spatial memory in rats with Alzheimer's Disease (AD). Alzheimer's disease is a progressive neurodegenerative disease clinically characterized by dementia and neurobehavioral deterioration. Forty five aged male wistar rats were divided randomly into three equal number groups (n = 15). Control; AD and GSE+AD. The rat model of Alzheimer's disease was induced by local injection of Ibotenic acid (Ibo) into brain Nucleus Basalis Magnocellularis (NBM) or meynert bilaterally (Ibo, 6 μg μL-1 each site) under stereotaxic surgery. The spatial memory performance was evaluated by Morris Water Maze task. The results show that injection of Ibo into NBM of rats could impair spatial memory capacity. The GSE supplementation (100 mg kg-1, by gavages) for 30 days before NBM lesion could be alleviating pre-lesion memory impairment. Present results showed that GSE could be a useful agent to prevent neurodegenerative disorders such as AD.
Farbood Y., Sarkaki A. and Badavi M., 2009. Preventive Effect of Grape Seed Hydroalcholic Extract on Dementia Type of Alzheimer's Disease in Aged Male Rats. International Journal of Pharmacology, 5: 257-262.